INT114509

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Context Info
Confidence 0.58
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 0.75
Pain Relevance 7.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Gria2) plasma membrane (Gria2) protein complex (Gria2)
Anatomy Link Frequency
amygdala 3
dorsal 1
brain 1
striatum 1
forebrain 1
Gria2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 64 100.00 Very High Very High Very High
Glutamate receptor 11 100.00 Very High Very High Very High
amygdala 30 99.68 Very High Very High Very High
nMDA receptor 19 99.60 Very High Very High Very High
Hippocampus 42 99.16 Very High Very High Very High
Morphine 44 98.74 Very High Very High Very High
opioid receptor 8 93.96 High High
agonist 29 93.32 High High
antagonist 50 93.12 High High
Neurotransmitter 13 91.16 High High
Disease Link Frequency Relevance Heat
Psychosis 8 93.92 High High
Schizophrenia 10 89.00 High High
Urological Neuroanatomy 2 83.00 Quite High
Drug Dependence 8 77.84 Quite High
Disease 4 51.16 Quite High
Death 2 48.64 Quite Low
Adenoma 5 39.24 Quite Low
Attention Deficit Hyperactivity Disorder 1 15.44 Low Low
Amnesia 4 14.72 Low Low
Cognitive Disorder 10 13.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The decreases in GluR2 mRNA expression in the amygdala and hippocampus may result in the formation of calcium-permeable AMPA receptors, which are believed to play an important role in behavioural sensitization.
Transcription (expression) of GluR2 in amygdala associated with hippocampus and amygdala
1) Confidence 0.58 Published 2008 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 18671727 Disease Relevance 0 Pain Relevance 0.76
However, GluR2 mRNA level as shown by in situ hybridization was already up-regulated above controls after 10 hrs of KCl treatment (P < 0.01) and remained elevated with longer periods of depolarization.
Transcription (level) of GluR2
2) Confidence 0.44 Published 2003 Journal J. Neurocytol. Section Abstract Doc Link 14618102 Disease Relevance 0 Pain Relevance 0.40
In order to evaluate the mechanism underlying the behavioural responses, quantitative real-time reverse transcription-polymerase chain reaction was used to evaluate mRNA expression of the AMPA receptor subunits GluR2 and GluR3 in the striatum, prefrontal cortex, hippocampus, hypothalamus and amygdala of animals treated repeatedly with morphine. 3.
Transcription (expression) of GluR2 in striatum associated with hippocampus, amygdala and morphine
3) Confidence 0.43 Published 2008 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 18671727 Disease Relevance 0 Pain Relevance 0.79
In addition, repeated morphine treatment followed by 7 days (but not 24 h) washout decreased GluR2 mRNA expression in both the amygdala (by 50%) and hippocampus (by 35%).
Transcription (expression) of GluR2 in amygdala associated with hippocampus, amygdala and morphine
4) Confidence 0.43 Published 2008 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 18671727 Disease Relevance 0 Pain Relevance 0.86
Decreased AMPA GluR2, but not GluR3, mRNA expression in rat amygdala and dorsal hippocampus following morphine-induced behavioural sensitization.
Transcription (expression) of GluR2 in amygdala associated with hippocampus, amygdala and morphine
5) Confidence 0.37 Published 2008 Journal Clin. Exp. Pharmacol. Physiol. Section Title Doc Link 18671727 Disease Relevance 0 Pain Relevance 0.56
The mRNA level of GluR2 was increased in the forebrain cortex, GluR3 in the CPU, and GluR1 and GluR3 in the hypothalamus.
Transcription (level) of GluR2 in forebrain
6) Confidence 0.32 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2358913 Disease Relevance 0.65 Pain Relevance 0.50
Glutamate or certain aspartate analogues have been found to stimulate PRL, GH and LH release and rat anterior pituitary cells express mRNA of glutamate receptors GluR1, GluR2, GluR3, GluR4, GluR5, GluR6, GluR7, KA1 and KA2 subunits (765).
Transcription (express) of GluR2 in anterior pituitary associated with glutamate and glutamate receptor
7) Confidence 0.23 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.61
The decreases in GluR2 mRNA expression in the amygdala and hippocampus may result in the formation of calcium-permeable AMPA receptors, which are believed to play an important role in behavioural sensitization.
Transcription (expression) of GluR2 in hippocampus associated with hippocampus and amygdala
8) Confidence 0.20 Published 2008 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 18671727 Disease Relevance 0 Pain Relevance 0.76
In order to evaluate the mechanism underlying the behavioural responses, quantitative real-time reverse transcription-polymerase chain reaction was used to evaluate mRNA expression of the AMPA receptor subunits GluR2 and GluR3 in the striatum, prefrontal cortex, hippocampus, hypothalamus and amygdala of animals treated repeatedly with morphine. 3.
Transcription (expression) of GluR2 in prefrontal associated with hippocampus, amygdala and morphine
9) Confidence 0.15 Published 2008 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 18671727 Disease Relevance 0 Pain Relevance 0.79
The mRNA levels of glutamate transporters (EAAT1, EAAT2-1, EAAT2-2), AMPA receptor subunits (GluR1, GluR2, GluR3), NMDA receptor subunits (NR1, NR2A and NR2B), as well as metabotropic glutamate receptors (mGluR1, mGluR2, mGluR3, mGluR5) were confirmed in six regions of the male rat brain (the prefrontal cortex (PFC), cortex, caudate putamen (CPU), nucleus accumbens (Acb), hippocampus and hypothalamus.
Transcription (levels) of GluR2 in brain associated with nucleus accumbens, glutamate, glutamate receptor, nmda receptor and hippocampus
10) Confidence 0.14 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2358913 Disease Relevance 0.11 Pain Relevance 0.67
Decreased AMPA GluR2, but not GluR3, mRNA expression in rat amygdala and dorsal hippocampus following morphine-induced behavioural sensitization.
Transcription (expression) of GluR2 in dorsal associated with hippocampus, amygdala and morphine
11) Confidence 0.13 Published 2008 Journal Clin. Exp. Pharmacol. Physiol. Section Title Doc Link 18671727 Disease Relevance 0 Pain Relevance 0.56

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