INT114510

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Context Info
Confidence 0.57
First Reported 2003
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 36
Total Number 42
Disease Relevance 14.91
Pain Relevance 14.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Gria2) plasma membrane (Gria2) protein complex (Gria2)
Anatomy Link Frequency
synapses 8
retinas 2
dorsal horn 2
plasma 1
spinal cord 1
Gria2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 684 100.00 Very High Very High Very High
nMDA receptor 135 100.00 Very High Very High Very High
Spinal cord 132 100.00 Very High Very High Very High
c fibre 4 100.00 Very High Very High Very High
Inflammation 104 99.98 Very High Very High Very High
tetrodotoxin 24 99.84 Very High Very High Very High
Dorsal horn 91 99.68 Very High Very High Very High
qutenza 12 99.68 Very High Very High Very High
Glutamate receptor 223 99.64 Very High Very High Very High
Glutamate 206 99.58 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 684 100.00 Very High Very High Very High
INFLAMMATION 104 99.98 Very High Very High Very High
Diabetes Mellitus 525 99.04 Very High Very High Very High
Ganglion Cysts 39 99.00 Very High Very High Very High
Inflammatory Pain 112 98.88 Very High Very High Very High
Cognitive Disorder 20 95.88 Very High Very High Very High
Hypoxia 144 95.52 Very High Very High Very High
Psychosis 4 93.56 High High
Amnesia 5 92.56 High High
Stress 147 91.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Repeated dopamine (DA) treatment, which leads to upregulation of surface GluR1 and GluR2, occluded activity blockade-induced synaptic scaling.
Positive_regulation (upregulation) of GluR2 associated with dopamine
1) Confidence 0.57 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19674091 Disease Relevance 0 Pain Relevance 0.60
Moreover, it was reported that the transcript levels for GluR1, GluR2, GluR3, NR2A, and NR2B subunits are significantly upregulated in the dorsal horn of the spinal cord in STZ-induced diabetic rats [21].
Positive_regulation (upregulated) of GluR2 in spinal cord associated with diabetes mellitus, dorsal horn and spinal cord
2) Confidence 0.46 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728563 Disease Relevance 1.20 Pain Relevance 0.45
The mRNA level of GluR2 was increased in the forebrain cortex, GluR3 in the CPU, and GluR1 and GluR3 in the hypothalamus.
Positive_regulation (increased) of GluR2 in forebrain
3) Confidence 0.42 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2358913 Disease Relevance 0.64 Pain Relevance 0.50
However, GluR2 mRNA level as shown by in situ hybridization was already up-regulated above controls after 10 hrs of KCl treatment (P < 0.01) and remained elevated with longer periods of depolarization.
Positive_regulation (up-regulated) of GluR2
4) Confidence 0.41 Published 2003 Journal J. Neurocytol. Section Abstract Doc Link 14618102 Disease Relevance 0 Pain Relevance 0.40
However, GluR2 mRNA level as shown by in situ hybridization was already up-regulated above controls after 10 hrs of KCl treatment (P < 0.01) and remained elevated with longer periods of depolarization.
Positive_regulation (elevated) of GluR2
5) Confidence 0.41 Published 2003 Journal J. Neurocytol. Section Abstract Doc Link 14618102 Disease Relevance 0 Pain Relevance 0.41
We have also found an increase in GluR2/3 subunits, suggesting that GluR3 subunit is upregulated in diabetic rat retinas.
Positive_regulation (increase) of GluR2 in retinas associated with diabetes mellitus
6) Confidence 0.40 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728563 Disease Relevance 0.53 Pain Relevance 0.18
The amount of GluR2 was markedly increased in the crude cytosolic fraction and decreased in the crude membrane fraction from the ipsilateral L4–5 dorsal horn at 24 h (but not at 2 h) post-CFA injection.
Positive_regulation (increased) of GluR2 in dorsal horn associated with dorsal horn
7) Confidence 0.40 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2628655 Disease Relevance 0.50 Pain Relevance 0.50
A previous study reported that CFA-induced persistent inflammation increased expression of GluR1 and GluR2 mRNA and the density of total GluR1 and GluR2 immunohistochemical staining in dorsal horn [12], suggesting that the levels of GluR1 and GluR2 may be increased in both plasma membrane and cytosolic fractions of dorsal horn neurons after CFA injection.
Positive_regulation (increased) of GluR2 in dorsal horn associated with inflammation, dorsal horn and dorsal horn neuron
8) Confidence 0.37 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.76 Pain Relevance 1.06
9-tetrahydrocannabinol (THC), induced GluR2-lacking AMPAR insertion into the PPN Glu-DA synapses without significant effects on the local Glu-DA synapses, thus permitting subsequent expression of mGluR-dependent LTD through GluR2-containing AMPAR reinsertion at the PPN Glu-DA synapses [16].
Positive_regulation (induced) of GluR2 in synapses associated with depression
9) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004941 Disease Relevance 0.26 Pain Relevance 0.98
Rats received TAT-GluR2 or its scrambled sequence (1.5 µmol/kg, i.p.) either at 2 h before each of four HU210 injections for conditioning or at 22 h after conditioning.
Positive_regulation (received) of GluR2
10) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004941 Disease Relevance 0.68 Pain Relevance 0.78
After 20 hrs of KCl treatment, GluR2 immunoreactivity and CO activity were significantly increased above controls (P < 0.01), and both remained high at 30 and 40 hrs of treatment.
Positive_regulation (increased) of GluR2
11) Confidence 0.33 Published 2003 Journal J. Neurocytol. Section Abstract Doc Link 14618102 Disease Relevance 0 Pain Relevance 0.41
The level of postsynaptic GluR1, but not GluR2 or GluR3, at lamina II nonpeptidergic C-fiber synapses was increased during capsaicin-induced acute inflammation [10].
Positive_regulation (increased) of GluR2 in synapses associated with c fibre, inflammation and qutenza
12) Confidence 0.32 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 1.07 Pain Relevance 1.20
Previous work has shown that corticosterone facilitates the recruitment of GluA2-AMPARs by enhancing lateral diffusion, and increases both GluA2-AMPAR synaptic surface content and surface mobility in cultured hippocampal neurons [10], [11].
Positive_regulation (increases) of GluA2 in neurons
13) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.52 Pain Relevance 0.24
Previously, in cultured retinal neural cells, we found that the protein levels of GluR1 and GluR6/7 subunits decrease and GluR2 and KA2 subunits increase [29].
Positive_regulation (increase) of GluR2 in neural
14) Confidence 0.31 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728563 Disease Relevance 0.55 Pain Relevance 0.34
The protein levels of GluR2/3 subunits increased after one, four, and 12 weeks of diabetes to 195±46%, 176±20%, and 334±116% of the control, respectively (Figure 1C).
Positive_regulation (increased) of GluR2 associated with diabetes mellitus
15) Confidence 0.31 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728563 Disease Relevance 1.19 Pain Relevance 0.03
The effects of corticosterone on AMPAR surface expression is also long lasting since surface GluR2 levels remain elevated 24 h after corticosterone application (and 21 h after washout).
Positive_regulation (elevated) of GluR2
16) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659165 Disease Relevance 0 Pain Relevance 0
This potentiation occurred through insertion of the higher conducting GluR2-lacking AMPAR into both synaptic pathways, which subsequently permitted expression of metabotropic glutamate receptor (mGluR)-dependent LTD through reinsertion of the lower conducting GluR2-containing AMPAR at these synapses [16].
Positive_regulation (conducting) of GluR2 in synapses associated with depression and glutamate receptor
17) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004941 Disease Relevance 0.25 Pain Relevance 0.94
Here we show in rats that chronic cannabinoid exposure activates VTA cannabinoid CB1 receptors to induce transient neurotransmission depression at VTA local Glu-DA synapses through activation of NMDA receptors and subsequent endocytosis of AMPA receptor GluR2 subunits.
Positive_regulation (activation) of GluR2 in synapses associated with ventral tegmentum, depression, nmda receptor and cannabinoid
18) Confidence 0.28 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3004941 Disease Relevance 0.69 Pain Relevance 1.39
Therefore, in the present study we utilized TAT-GluR2 for a selective disruption of LTD induction in both electrophysiological experiments and behavioral tests.
Positive_regulation (induction) of GluR2 associated with depression
19) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004941 Disease Relevance 0.64 Pain Relevance 0.39
However, a single exposure to THC induced GluR2-lacking AMPAR insertion into the PPN Glu-DA synapses without significant effects on the local Glu-DA synapses, thus permitting subsequent expression of mGluR-dependent LTD at the PPN Glu-DA synapses but not the local Glu-DA synapses [16].
Positive_regulation (induced) of GluR2 in synapses associated with depression
20) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004941 Disease Relevance 0.35 Pain Relevance 0.65

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