INT114511

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Context Info
Confidence 0.41
First Reported 2003
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 3.90
Pain Relevance 4.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Gria2) plasma membrane (Gria2) protein complex (Gria2)
Anatomy Link Frequency
NAc 2
retinas 2
neurons 2
lateral 2
Gria2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 137 100.00 Very High Very High Very High
Cannabinoid 58 100.00 Very High Very High Very High
ischemia 63 99.98 Very High Very High Very High
tetrodotoxin 11 99.84 Very High Very High Very High
Ventral tegmentum 102 99.68 Very High Very High Very High
Nucleus accumbens 14 99.20 Very High Very High Very High
imagery 30 98.96 Very High Very High Very High
Glutamate 90 98.92 Very High Very High Very High
antagonist 35 98.72 Very High Very High Very High
long-term potentiation 43 98.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 137 100.00 Very High Very High Very High
Cv Unclassified Under Development 51 99.98 Very High Very High Very High
Epilepsy 16 99.32 Very High Very High Very High
Herpes Simplex Virus 1 99.32 Very High Very High Very High
Death 17 98.64 Very High Very High Very High
Stress 97 98.20 Very High Very High Very High
Diabetes Mellitus 87 97.48 Very High Very High Very High
Status Epilepticus 57 97.24 Very High Very High Very High
Diabetic Retinopathy 9 80.96 Quite High
Ganglion Cysts 5 73.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TTX blockade, on the other hand, induced a significant down-regulation of GluR2 immunoreactivity, GluR2 gene expression as well as CO activity (P < 0.01 for all).
Positive_regulation (induced) of Gene_expression (expression) of GluR2 associated with tetrodotoxin
1) Confidence 0.41 Published 2003 Journal J. Neurocytol. Section Abstract Doc Link 14618102 Disease Relevance 0 Pain Relevance 0.37
A recent study used a drug-inducible expression of GluA2 subunit in stable HEK cell lines to gain control over the timing and subunit composition during AMPA-R biosynthesis [23].
Positive_regulation (inducible) of Gene_expression (expression) of GluA2
2) Confidence 0.37 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0 Pain Relevance 0.08
TTX blockade, on the other hand, induced a significant down-regulation of GluR2 immunoreactivity, GluR2 gene expression as well as CO activity (P < 0.01 for all).
Positive_regulation (induced) of Gene_expression (expression) of GluR2 associated with tetrodotoxin
3) Confidence 0.36 Published 2003 Journal J. Neurocytol. Section Abstract Doc Link 14618102 Disease Relevance 0 Pain Relevance 0.37
GluR1 and GluR2 surface expression was also increased by tetrodotoxin alone or in combination with an N-methyl-d-aspartate receptor or AMPA receptor antagonist but not by the l-type Ca(2+) channel antagonist nifedipine.
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of GluR2 associated with tetrodotoxin and antagonist
4) Confidence 0.36 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19674091 Disease Relevance 0.07 Pain Relevance 0.65
The pivotal role of GluR2 endocytosis in cannabinoid-facilitated LTD expression in the VTA is supported by our findings that bath application of TAT-GluR2, but not its scrambled sequence, blocked LTD expression in HU210-treated rats (Figure 4C,D).
Positive_regulation (facilitated) of Gene_expression (expression) of GluR2 associated with ventral tegmentum, depression and cannabinoid
5) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004941 Disease Relevance 0.69 Pain Relevance 1.26
Moreover, we showed that elevated glucose concentration changes the protein levels of GluR1, GluR2, GluR6/7, and KA2 subunits in cultured rat retinal neural cells [29], and more recently, we have demonstrated, in postmortem human retinas, that there are alterations in the levels of ionotropic glutamate receptor subunits in diabetic patients [30].
Positive_regulation (changes) of Gene_expression (levels) of GluR2 in retinas associated with diabetes mellitus and glutamate receptor
6) Confidence 0.27 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728563 Disease Relevance 1.16 Pain Relevance 0.42
In agreement, we report that corticosterone also dramatically increases the fraction of surface expressed GluR2 that undergo lateral diffusion.
Positive_regulation (increases) of Gene_expression (expressed) of GluR2 in lateral
7) Confidence 0.27 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2659165 Disease Relevance 0.14 Pain Relevance 0.11
Using immunocytochemistry and live cell imaging techniques we show that corticosterone selectively increases surface expression of the AMPAR subunit GluR2 in primary hippocampal cultures via a glucocorticoid receptor and protein synthesis dependent mechanism.
Positive_regulation (increases) of Gene_expression (expression) of GluR2 associated with imagery
8) Confidence 0.27 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2659165 Disease Relevance 0.16 Pain Relevance 0.09
Consistent with this, application of the GR antagonist RU38486 (500 nM) completely blocked the corticosterone-induced increase in GluR2 surface expression and co-treatment of corticosterone with the protein synthesis inhibitor cycloheximide (100 ┬ÁM) also fully prevented the effects of corticosterone on GluR2 surface expression (Figure 1H).
Positive_regulation (increase) of Gene_expression (expression) of GluR2 associated with antagonist
9) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659165 Disease Relevance 0 Pain Relevance 0.05
When overexpressed in HEK cells, the mutant GluK2 subunits that cannot bind glutamate were detected as a mixture of monomer, dimer, tetramers, and high molecular weight misfolded aggregates, the latter being the majority [169].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of GluK2 associated with glutamate
10) Confidence 0.23 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0 Pain Relevance 0.05
In contrast, the increased phosphorylation of the Ser880-GluA2 residue in the mPFC that we observed suggests acute stress increases AMPAR internalization and facilitates the generation of LTD in that region.
Positive_regulation (increased) of Gene_expression (residue) of GluA2 associated with stress
11) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.62 Pain Relevance 0.37
Here we report that prolonged corticosterone treatment increases GluR2 surface expression in a time and concentration dependent manner.
Positive_regulation (increases) of Gene_expression (expression) of GluR2
12) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659165 Disease Relevance 0.06 Pain Relevance 0.03
Here, we used herpes simplex virus vectors to examine how transient increases in the expression of GluR1 or GluR2 protein in the shell component of NAc affect the rewarding impact of electrical stimulation of the medial forebrain bundle, as reflected by intracranial self-stimulation (ICSS) thresholds in rats.
Spec (examine) Positive_regulation (increases) of Gene_expression (expression) of GluR2 protein in NAc associated with nucleus accumbens and herpes simplex virus
13) Confidence 0.13 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 17093088 Disease Relevance 0.10 Pain Relevance 0.37
As an analogy to hippocampal neurons [10], we speculate that an ischemia-induced alteration of GluR2 expression in Deiter's neurons induced cell death.
Positive_regulation (induced) of Gene_expression (expression) of GluR2 in neurons associated with ischemia and death
14) Confidence 0.10 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2949765 Disease Relevance 0.52 Pain Relevance 0.19
Decreased expression of the AMPA receptor GluR2 subunit gene has earlier been detected in the CA3 region shortly after KA-induced and electrically-induced SE in adult rats, in keeping with our present finding [16], [93].
Positive_regulation (detected) of Gene_expression (expression) of AMPA receptor GluR2 subunit gene associated with status epilepticus
15) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873964 Disease Relevance 0.39 Pain Relevance 0.30

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