INT114513

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Context Info
Confidence 0.48
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 0.89
Pain Relevance 2.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Gria2) plasma membrane (Gria2) protein complex (Gria2)
Anatomy Link Frequency
amygdala 2
Gria2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 4 99.48 Very High Very High Very High
antagonist 4 99.42 Very High Very High Very High
tetrodotoxin 11 98.96 Very High Very High Very High
Morphine 6 98.94 Very High Very High Very High
Hippocampus 25 98.60 Very High Very High Very High
nMDA receptor 20 97.40 Very High Very High Very High
Glutamate receptor 33 96.00 Very High Very High Very High
Glutamate 18 70.00 Quite High
Pyramidal cell 24 68.12 Quite High
Neurotransmitter 4 51.60 Quite High
Disease Link Frequency Relevance Heat
Epilepsy 16 99.72 Very High Very High Very High
Status Epilepticus 57 96.20 Very High Very High Very High
Diabetes Mellitus 87 93.64 High High
Toxicity 2 71.84 Quite High
Diabetic Retinopathy 9 58.72 Quite High
Convulsion 18 33.52 Quite Low
Ganglion Cysts 5 5.60 Low Low
Depression 22 5.00 Very Low Very Low Very Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Stress 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TTX blockade, on the other hand, induced a significant down-regulation of GluR2 immunoreactivity, GluR2 gene expression as well as CO activity (P < 0.01 for all).
Negative_regulation (down) of Gene_expression (expression) of GluR2 associated with tetrodotoxin
1) Confidence 0.48 Published 2003 Journal J. Neurocytol. Section Abstract Doc Link 14618102 Disease Relevance 0 Pain Relevance 0.34
Of particular interest is the significant downregulation of GluR2 subunit protein expression, found at all three time points studied.
Negative_regulation (downregulation) of Gene_expression (expression) of GluR2
2) Confidence 0.39 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728563 Disease Relevance 0.50 Pain Relevance 0.34
TTX blockade, on the other hand, induced a significant down-regulation of GluR2 immunoreactivity, GluR2 gene expression as well as CO activity (P < 0.01 for all).
Negative_regulation (regulation) of Gene_expression (expression) of GluR2 associated with tetrodotoxin
3) Confidence 0.35 Published 2003 Journal J. Neurocytol. Section Abstract Doc Link 14618102 Disease Relevance 0 Pain Relevance 0.34
In addition, repeated morphine treatment followed by 7 days (but not 24 h) washout decreased GluR2 mRNA expression in both the amygdala (by 50%) and hippocampus (by 35%).
Negative_regulation (decreased) of Gene_expression (expression) of GluR2 in amygdala associated with hippocampus, amygdala and morphine
4) Confidence 0.34 Published 2008 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 18671727 Disease Relevance 0 Pain Relevance 0.86
TTX blockade, on the other hand, induced a significant down-regulation of GluR2 immunoreactivity, GluR2 gene expression as well as CO activity (P < 0.01 for all).
Negative_regulation (down-regulation) of Gene_expression (expression) of GluR2 associated with tetrodotoxin
5) Confidence 0.31 Published 2003 Journal J. Neurocytol. Section Abstract Doc Link 14618102 Disease Relevance 0 Pain Relevance 0.34
Consistent with this, application of the GR antagonist RU38486 (500 nM) completely blocked the corticosterone-induced increase in GluR2 surface expression and co-treatment of corticosterone with the protein synthesis inhibitor cycloheximide (100 µM) also fully prevented the effects of corticosterone on GluR2 surface expression (Figure 1H).
Negative_regulation (blocked) of Gene_expression (expression) of GluR2 associated with antagonist
6) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659165 Disease Relevance 0 Pain Relevance 0.05
Consistent with this, application of the GR antagonist RU38486 (500 nM) completely blocked the corticosterone-induced increase in GluR2 surface expression and co-treatment of corticosterone with the protein synthesis inhibitor cycloheximide (100 µM) also fully prevented the effects of corticosterone on GluR2 surface expression (Figure 1H).
Negative_regulation (prevented) of Gene_expression (expression) of GluR2 associated with antagonist
7) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659165 Disease Relevance 0 Pain Relevance 0.05
Decreased expression of the AMPA receptor GluR2 subunit gene has earlier been detected in the CA3 region shortly after KA-induced and electrically-induced SE in adult rats, in keeping with our present finding [16], [93].
Negative_regulation (Decreased) of Gene_expression (expression) of AMPA receptor GluR2 subunit gene associated with status epilepticus
8) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873964 Disease Relevance 0.39 Pain Relevance 0.27

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