INT114519

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Context Info
Confidence 0.57
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 13.01
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
heart 2
Hcm (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 16 99.48 Very High Very High Very High
Angina 15 97.52 Very High Very High Very High
fibrosis 27 97.28 Very High Very High Very High
antagonist 3 64.80 Quite High
beta blocker 2 63.84 Quite High
tolerance 8 49.20 Quite Low
cva 1 45.80 Quite Low
ischemia 23 35.16 Quite Low
imagery 68 33.68 Quite Low
alcohol 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophic Cardiomyopathy 479 100.00 Very High Very High Very High
Sudden Death 28 99.56 Very High Very High Very High
Myocardial Infarction 95 99.46 Very High Very High Very High
Syncope 13 98.84 Very High Very High Very High
Pressure And Volume Under Development 16 98.80 Very High Very High Very High
Muscular Dystrophy 1 98.80 Very High Very High Very High
Aneurism 25 98.78 Very High Very High Very High
Dizziness 1 98.00 Very High Very High Very High
Cystic Fibrosis 1 97.56 Very High Very High Very High
Hypertrophy 251 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although HCM is often caused by an identifiable mutation in a gene coding for a sarcomeric protein and inherited in an autosomal-dominant pattern, many patients do not have any relatives in whom the disease is manifest.
Gene_expression (caused) of HCM associated with hypertrophic cardiomyopathy and disease
1) Confidence 0.57 Published 2008 Journal Cardiol Rev Section Abstract Doc Link 18562807 Disease Relevance 1.47 Pain Relevance 0.10
Nowadays, echocardiography is the method of choice in the detection of HCM.
Gene_expression (detection) of HCM associated with hypertrophic cardiomyopathy
2) Confidence 0.51 Published 2003 Journal Kardiol Pol Section Abstract Doc Link 14618200 Disease Relevance 0.53 Pain Relevance 0.26
Recently, it has been demonstrated [17] that mutations in the alpha-cardiac actin gene can express apical HCM or LV non compaction or septal defects.
Gene_expression (express) of HCM associated with hypertrophic cardiomyopathy
3) Confidence 0.43 Published 2010 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2848131 Disease Relevance 1.24 Pain Relevance 0
HCM is in many cases not a devastating condition and usually it does not produce symptoms in children, unlike Duchenne muscular dystrophy or cystic fibrosis.
Neg (not) Gene_expression (produce) of HCM associated with fibrosis, hypertrophic cardiomyopathy, muscular dystrophy and cystic fibrosis
4) Confidence 0.42 Published 2000 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC59597 Disease Relevance 0.69 Pain Relevance 0.05
Diagnosis of HCM in athletes is important, given the high propensity to sudden cardiac death in HCM patients engaging in competitive sports as well as other physically intense activity [39].
Gene_expression (Diagnosis) of HCM associated with hypertrophic cardiomyopathy and myocardial infarction
5) Confidence 0.37 Published 2010 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2848131 Disease Relevance 2.12 Pain Relevance 0
Athletic heart and HCM
Gene_expression (heart) of HCM in heart associated with hypertrophic cardiomyopathy
6) Confidence 0.37 Published 2010 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2848131 Disease Relevance 2.23 Pain Relevance 0
In fact, although the gross phenotypic expression and clinical profile of HCM may occasionally be identified in infants and young children, marked LV hypertrophy is rarely documented during the first years of life [23].
Gene_expression (expression) of HCM associated with hypertrophy and hypertrophic cardiomyopathy
7) Confidence 0.33 Published 2010 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2848131 Disease Relevance 1.13 Pain Relevance 0
Several reports have shown the association between mid-ventricular and apical HCM and apical aneurysms, but this is the first case presenting a special phenotypic expression of HCM, characterized by a combination of asymmetric septal and mid-ventricular HCM that presents clinically as an infarction with normal coronary arteries and develops an apical aneurysm.


Gene_expression (expression) of HCM associated with hypertrophic cardiomyopathy, aneurism and infarction
8) Confidence 0.26 Published 2006 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1501052 Disease Relevance 1.48 Pain Relevance 0.06
We identified an HCM-causative mutation in one of the five most commonly mutated sarcomeric genes (MYH7, MYBPC3, TPM1, TNNI3, or TNNT2) in 40 cases, but we cannot exclude that other patients harbour mutations in any of the other genes that have been linked to HCM.
Gene_expression (identified) of HCM associated with hypertrophic cardiomyopathy
9) Confidence 0.19 Published 2010 Journal J Transl Med Section Body Doc Link PMC2907326 Disease Relevance 0.43 Pain Relevance 0.05
Patients with advanced heart failure were 41 ± 20 years old at HCM diagnosis and 48 ± 19 years at HCM-related heart failure symptom onset (interval 7 ± 9 years).
Gene_expression (diagnosis) of HCM in heart associated with hypertrophic cardiomyopathy and myocardial infarction
10) Confidence 0.06 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2930982 Disease Relevance 1.70 Pain Relevance 0.06

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