INT114525

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Context Info
Confidence 0.35
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.93
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Egf) plasma membrane (Egf)
Anatomy Link Frequency
salivary gland 4
Egf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nicotine 22 99.98 Very High Very High Very High
Nerve growth factor 126 86.72 High High
agonist 3 77.84 Quite High
cINOD 2 76.88 Quite High
alcohol 4 75.36 Quite High
Bile 4 66.40 Quite High
Action potential 15 5.00 Very Low Very Low Very Low
Neuronal excitability 14 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
tetrodotoxin 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 32 99.72 Very High Very High Very High
Ganglion Cysts 44 80.84 Quite High
Stress 2 77.84 Quite High
INFLAMMATION 11 76.64 Quite High
Apoptosis 4 75.68 Quite High
Peptic Ulcer 6 75.00 Quite High
Ulcers 6 69.68 Quite High
Gastric Motility Disorder 2 68.80 Quite High
Adult Respiratory Distress Syndrome 14 44.04 Quite Low
Duodenal Ulcer 2 43.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cigarette smoking and nicotine reduce the level of circulating epidermal growth factor (EGF) and decrease the secretion of EGF from the salivary gland, which are necessary for gastric mucosal cell renewal.
Negative_regulation (reduce) of Positive_regulation (circulating) of EGF in salivary gland associated with nicotine addiction and nicotine
1) Confidence 0.35 Published 2003 Journal Mol. Cell. Biochem. Section Abstract Doc Link 14619984 Disease Relevance 1.39 Pain Relevance 0.52
Cigarette smoking and nicotine reduce the level of circulating epidermal growth factor (EGF) and decrease the secretion of EGF from the salivary gland, which are necessary for gastric mucosal cell renewal.
Negative_regulation (reduce) of Positive_regulation (circulating) of epidermal growth factor in salivary gland associated with nicotine addiction and nicotine
2) Confidence 0.35 Published 2003 Journal Mol. Cell. Biochem. Section Abstract Doc Link 14619984 Disease Relevance 1.39 Pain Relevance 0.52
We inhibited EGF activation in 2CLP and sham monolayers (N?
Negative_regulation (inhibited) of Positive_regulation (activation) of EGF
3) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892473 Disease Relevance 0 Pain Relevance 0
Activation of the muscarinic receptor inhibits M/KCNQ currents through depletion of membrane PtdIns(4,5)P2 resulting from hydrolysis (Zhang et al., 2003); activation of the EGF receptor inhibits M/KCNQ currents through both depletion of membrane PtdIns(4,5)P2 and channel tyrosine phosphorylation (Jia et al., 2007).
Negative_regulation (inhibits) of Positive_regulation (activation) of EGF
4) Confidence 0.17 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2391251 Disease Relevance 0.15 Pain Relevance 0.46

General Comments

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