INT114546

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Context Info
Confidence 0.39
First Reported 2003
Last Reported 2003
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.19
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) extracellular space (Ins1) extracellular region (Ins1)
plasma membrane (Trpv1) carbohydrate metabolic process (Ins1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
primary sensory neurons 2
Ins1 (Rattus norvegicus)
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
burning pain 2 96.20 Very High Very High Very High
antagonist 2 86.20 High High
qutenza 16 77.92 Quite High
Disease Link Frequency Relevance Heat
Pain 2 96.20 Very High Very High Very High
Hyperinsulinism 2 95.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the insulin-induced activation of vanilloid receptor 1 seems to be a short-lived effect in vitro, in vivo it might play a role in the development of burning pain sensation in hyperinsulinism.
insulin Positive_regulation (induced) of Positive_regulation (activation) of vanilloid receptor 1 associated with hyperinsulinism and burning pain
1) Confidence 0.39 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622148 Disease Relevance 0.19 Pain Relevance 0.39
These findings suggest that insulin activates a subpopulation of primary sensory neurons, probably through phosphorylation- and/or phosphatidylinositol(4,5)biphosphate hydrolysis-evoked activation of the vanilloid receptor 1.
insulin Spec (probably) Positive_regulation (activates) of Positive_regulation (activation) of vanilloid receptor 1 in primary sensory neurons
2) Confidence 0.39 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622148 Disease Relevance 0 Pain Relevance 0.47

General Comments

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