INT114562

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Context Info
Confidence 0.76
First Reported 2003
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 6
Total Number 11
Disease Relevance 0.56
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Kcnj9) molecular_function (Kcnj9) biological_process (Kcnj9)
Anatomy Link Frequency
neurons 3
brains 1
oocytes 1
Kcnj9 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 28 100.00 Very High Very High Very High
Analgesic 11 100.00 Very High Very High Very High
agonist 68 98.04 Very High Very High Very High
Pyramidal cell 16 96.56 Very High Very High Very High
addiction 7 85.72 High High
gABA 18 84.28 Quite High
Neurotransmitter 42 84.08 Quite High
potassium channel 12 79.16 Quite High
nMDA receptor 36 60.16 Quite High
Opioid 3 50.00 Quite Low
Disease Link Frequency Relevance Heat
Bordatella Infection 50 94.08 High High
Ganglion Cysts 36 90.84 High High
Glioma 8 5.00 Very Low Very Low Very Low
Neuroblastoma 8 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Hyperalgesia 4 5.00 Very Low Very Low Very Low
Acute Coronary Syndrome 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to ascertain which Kir3.x subunits were responsible for the native GIRK current I compared the properties with those of the cloned Kir3.1 + 3.2A and Kir3.1 + 3.2C channels heterologously expressed in HEK293 cells.
Gene_expression (expressed) of Kir3
1) Confidence 0.76 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622172 Disease Relevance 0.09 Pain Relevance 0.14
In order to ascertain which Kir3.x subunits were responsible for the native GIRK current I compared the properties with those of the cloned Kir3.1 + 3.2A and Kir3.1 + 3.2C channels heterologously expressed in HEK293 cells.
Gene_expression (expressed) of Kir3
2) Confidence 0.76 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622172 Disease Relevance 0.09 Pain Relevance 0.14
Contribution of Kir3.1, Kir3.2A and Kir3.2C subunits to native G protein-gated inwardly rectifying potassium currents in cultured hippocampal neurons.
Gene_expression (Contribution) of Kir3 in neurons associated with adenocard
3) Confidence 0.66 Published 2003 Journal Eur. J. Neurosci. Section Title Doc Link 14622172 Disease Relevance 0 Pain Relevance 0.34
Contribution of Kir3.1, Kir3.2A and Kir3.2C subunits to native G protein-gated inwardly rectifying potassium currents in cultured hippocampal neurons.
Gene_expression (Contribution) of Kir3 in neurons associated with adenocard
4) Confidence 0.66 Published 2003 Journal Eur. J. Neurosci. Section Title Doc Link 14622172 Disease Relevance 0 Pain Relevance 0.33
Contribution of Kir3.1, Kir3.2A and Kir3.2C subunits to native G protein-gated inwardly rectifying potassium currents in cultured hippocampal neurons.
Gene_expression (Contribution) of Kir3 in neurons associated with adenocard
5) Confidence 0.66 Published 2003 Journal Eur. J. Neurosci. Section Title Doc Link 14622172 Disease Relevance 0 Pain Relevance 0.34
Reverse transcriptase-polymerase chain reaction revealed the expression of mRNA for Kir3.1, 3.2A, 3.2C and 3.3 subunits and confocal immunofluorescence microscopy was used to investigate their expression patterns.
Spec (investigate) Gene_expression (expression) of Kir3
6) Confidence 0.66 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622172 Disease Relevance 0.06 Pain Relevance 0.25
Expression of Kir3.2 in the Edinger-Westphal nucleus of rat brains was analyzed by means of immunohistochemistry.
Spec (analyzed) Gene_expression (Expression) of Kir3 in brains
7) Confidence 0.30 Published 2010 Journal Pharmacogenet. Genomics Section Body Doc Link 20220551 Disease Relevance 0 Pain Relevance 0
Similar results were also obtained with the mouse P2Y2 receptor, but not with human P2Y6, when expressed together with GIRK channels in Xenopus oocytes [121].


Gene_expression (expressed) of GIRK in oocytes
8) Confidence 0.08 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096562 Disease Relevance 0.05 Pain Relevance 0.18
A more unexpected finding was that the Gq/11-linked P2Y1 receptor, when co-expressed with Kir3.1 and 3.2 subunits instead of P2Y12, also produced a PTX-sensitive activation of GIRK.
Gene_expression (expressed) of Kir3
9) Confidence 0.07 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096562 Disease Relevance 0.08 Pain Relevance 0.12
When rat GIRK1 and GIRK2 (Kir3.1 and 3.2 subunits) were co-expressed, 2MeSADP and 2MeSATP, two potent P2Y12 receptor agonists, evoked a K+ current through GIRK channels.
Gene_expression (expressed) of Kir3 associated with agonist
10) Confidence 0.06 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096562 Disease Relevance 0.09 Pain Relevance 0.12
When rat GIRK1 and GIRK2 (Kir3.1 and 3.2 subunits) were co-expressed, 2MeSADP and 2MeSATP, two potent P2Y12 receptor agonists, evoked a K+ current through GIRK channels.
Gene_expression (-) of Kir3 associated with agonist
11) Confidence 0.06 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096562 Disease Relevance 0.09 Pain Relevance 0.12

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