INT114571

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Context Info
Confidence 0.77
First Reported 2003
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 39
Total Number 46
Disease Relevance 36.78
Pain Relevance 3.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Sigmar1) nuclear envelope (Sigmar1) lipid particle (Sigmar1)
endoplasmic reticulum (Sigmar1) plasma membrane (Sigmar1) nucleus (Sigmar1)
Anatomy Link Frequency
pancreas 8
brain 4
GCs 3
liver 2
spleen 2
Sigmar1 (Mus musculus)
Pain Link Frequency Relevance Heat
fortral 136 100.00 Very High Very High Very High
imagery 232 99.32 Very High Very High Very High
opioid receptor 10 92.48 High High
analgesia 1 89.64 High High
depression 1 89.20 High High
agonist 25 85.52 High High
Pain 5 82.40 Quite High
cocaine 6 79.12 Quite High
Opioid 7 76.36 Quite High
Neuropathic pain 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 914 100.00 Very High Very High Very High
Cancer 2223 99.84 Very High Very High Very High
Adenocarcinoma 213 99.48 Very High Very High Very High
Hyperplasia 25 99.48 Very High Very High Very High
Apoptosis 1441 99.40 Very High Very High Very High
Malignant Neoplastic Disease 32 99.28 Very High Very High Very High
Skin Cancer 25 99.04 Very High Very High Very High
Immunotherapy Of Cancer 39 98.96 Very High Very High Very High
Nociception 2 98.80 Very High Very High Very High
Targeted Disruption 7 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Type 1 sigmaR1 (sigmaR1) is expressed in brain oligodendrocytes, but its expression and binding capacity have not been analyzed in retinal glial cells.
Gene_expression (expressed) of sigmaR1 in glial cells
1) Confidence 0.77 Published 2006 Journal Invest. Ophthalmol. Vis. Sci. Section Abstract Doc Link 17122151 Disease Relevance 0 Pain Relevance 0
Type 1 sigmaR1 (sigmaR1) is expressed in brain oligodendrocytes, but its expression and binding capacity have not been analyzed in retinal glial cells.
Gene_expression (expressed) of sigmaR1 in glial cells
2) Confidence 0.77 Published 2006 Journal Invest. Ophthalmol. Vis. Sci. Section Abstract Doc Link 17122151 Disease Relevance 0 Pain Relevance 0
Expression, subcellular localization, and regulation of sigma receptor in retinal muller cells.
Gene_expression (Expression) of sigma receptor in muller cells associated with fortral
3) Confidence 0.77 Published 2006 Journal Invest. Ophthalmol. Vis. Sci. Section Title Doc Link 17122151 Disease Relevance 0 Pain Relevance 0.20
RESULTS: Primary GCs showed robust sigmaR1 expression.
Gene_expression (expression) of sigmaR1 in GCs
4) Confidence 0.74 Published 2007 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 17898305 Disease Relevance 0.07 Pain Relevance 0
Here we reported that sigma-2 receptor is highly expressed in human and mouse pancreatic cancer cells, and sigma-2 receptor-selective ligands induce tumor apoptosis in a caspase-3 dependent manner.
Gene_expression (expressed) of sigma-2 receptor associated with cancer, pancreatic cancer and apoptosis
5) Confidence 0.70 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1939854 Disease Relevance 1.49 Pain Relevance 0.07
Mouse and human pancreatic cancer cell lines as well as established Panc-02 tumor allografts established in C57Bl/6 mice expressed the sigma-2 receptor at significantly higher levels than normal mouse tissues, and the selective accumulation of the sigma-2 receptor ligand in the tumor could be used to image the tumor in vivo.
Gene_expression (expressed) of sigma-2 receptor in Mouse associated with cancer and pancreatic cancer
6) Confidence 0.70 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1939854 Disease Relevance 1.65 Pain Relevance 0.08
This study examined the expression, subcellular localization, binding activity, and regulation of sigmaR1 in retinal Müller cells.
Spec (examined) Gene_expression (expression) of sigmaR1
7) Confidence 0.67 Published 2006 Journal Invest. Ophthalmol. Vis. Sci. Section Abstract Doc Link 17122151 Disease Relevance 0 Pain Relevance 0
Despite the broad expression pattern found for the sigma 1-gene, homozygous mutant mice are viable, fertile and do not display any overt phenotype, compared with their wild-type litter-mates, in mixed genetic backgrounds.
Gene_expression (expression) of sigma 1
8) Confidence 0.66 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622179 Disease Relevance 0.52 Pain Relevance 0.13
METHODS: Primary mouse Müller cells (MCs) were analyzed by RT-PCR, immunoblotting, and immunocytochemistry for the expression of sigmaR1, and data were compared with those of the rat Müller cell line (rMC-1) and the rat ganglion cell line (RGC-5).
Gene_expression (pression o) of sigmaR1 in ganglion cell
9) Confidence 0.60 Published 2006 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 17122151 Disease Relevance 0 Pain Relevance 0
RESULTS: sigmaR1 is expressed in primary mouse MCs and is localized to the nuclear and endoplasmic reticulum membranes.
Gene_expression (ressed in) of sigmaR1 in reticulum
10) Confidence 0.60 Published 2006 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 17122151 Disease Relevance 0 Pain Relevance 0
We have previously reported that the sigma-2 receptor is highly expressed in pancreas cancer and weakly expressed in normal pancreas [13].
Gene_expression (expressed) of sigma-2 receptor in pancreas associated with pancreatic cancer
11) Confidence 0.59 Published 2009 Journal J Transl Med Section Body Doc Link PMC2669042 Disease Relevance 1.18 Pain Relevance 0.11
We have previously reported that the sigma-2 receptor is highly expressed in pancreas cancer and weakly expressed in normal pancreas [13].
Gene_expression (expressed) of sigma-2 receptor in pancreas associated with pancreatic cancer
12) Confidence 0.59 Published 2009 Journal J Transl Med Section Body Doc Link PMC2669042 Disease Relevance 1.20 Pain Relevance 0.11
Several groups of investigators have shown that sigma-2 receptor expression is markedly increased across diverse malignancies.
Gene_expression (expression) of sigma-2 receptor
13) Confidence 0.59 Published 2009 Journal J Transl Med Section Body Doc Link PMC2669042 Disease Relevance 0.90 Pain Relevance 0.04
We have previously reported that murine (Panc-02) and human (AsPC-1, CFPAC-1, and Panc-1) pancreatic adenocarcinoma cell lines display increased expression of the sigma-2 receptor [13].
Gene_expression (expression) of sigma-2 receptor in CFPAC-1 associated with adenocarcinoma
14) Confidence 0.59 Published 2009 Journal J Transl Med Section Body Doc Link PMC2669042 Disease Relevance 0.50 Pain Relevance 0.06
Expression of sigmaR1 was assessed by immunocytochemistry, RT-PCR, and Western blotting.
Gene_expression (Expression) of sigmaR1
15) Confidence 0.58 Published 2007 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 17898305 Disease Relevance 0.08 Pain Relevance 0
CONCLUSIONS: Primary GCs express sigmaR1; their marked sensitivity to Glu and Hcy toxicity mimics the sensitivity observed in vivo, making them a highly relevant model for testing neuroprotection.
Gene_expression (express) of sigmaR1 in GCs
16) Confidence 0.58 Published 2007 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 17898305 Disease Relevance 0 Pain Relevance 0
Sigma-1 receptor (sigma(1)R) is expressed in key CNS areas involved in nociceptive processing but only limited information is available about its functional role.
Gene_expression (expressed) of Sigma-1 receptor associated with nociception
17) Confidence 0.56 Published 2009 Journal Pain Section Abstract Doc Link 19505761 Disease Relevance 0.55 Pain Relevance 0.34
Micro-PET imaging was used to demonstrate that the sigma-2 receptor was preferentially expressed in tumor as opposed to normal tissues in pancreas tumor allograft-bearing mice.
Gene_expression (expressed) of sigma-2 receptor in pancreas associated with cancer, pancreatic cancer and imagery
18) Confidence 0.55 Published 2007 Journal Mol Cancer Section Abstract Doc Link PMC1939854 Disease Relevance 1.40 Pain Relevance 0.09
The sigma-2 receptor has been characterized as a molecule that is highly expressed in rapidly proliferating cells and down-regulated when cells become quiescent[18].
Gene_expression (expressed) of sigma-2 receptor
19) Confidence 0.55 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1939854 Disease Relevance 0.89 Pain Relevance 0.05
Sigma-2 receptor expression has been reported in various human cancer cells such as breast[19], brain[20], bladder[21], colon and melanoma[22]; however, no studies have been reported on sigma-2 receptor expression in pancreas adenocarcinoma.
Gene_expression (expression) of sigma-2 receptor in pancreas associated with adenocarcinoma, cancer and skin cancer
20) Confidence 0.55 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1939854 Disease Relevance 1.01 Pain Relevance 0.04

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