INT114578

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Context Info
Confidence 0.47
First Reported 2003
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 18
Total Number 21
Disease Relevance 14.95
Pain Relevance 12.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Ceacam3) cellular_component (Ceacam3) biological_process (Ceacam3)
Anatomy Link Frequency
CeA 5
visceral 4
neurons 4
brain 2
Nucleus 1
Ceacam3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 1084 100.00 Very High Very High Very High
Central grey 442 100.00 Very High Very High Very High
Delta opioid receptors 5 100.00 Very High Very High Very High
agonist 48 99.98 Very High Very High Very High
Morphine 14 99.98 Very High Very High Very High
Dopamine 138 99.96 Very High Very High Very High
Visceral pain 27 99.84 Very High Very High Very High
Periaqueductal grey 6 99.84 Very High Very High Very High
Glutamate 9 99.26 Very High Very High Very High
withdrawal 42 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 491 100.00 Very High Very High Very High
Stress 590 99.84 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

27 99.84 Very High Very High Very High
Shock 383 99.24 Very High Very High Very High
Anxiety Disorder 443 98.28 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

72 97.08 Very High Very High Very High
Unconsciousness 12 93.84 High High
Cold Sores 105 92.04 High High
Pain 49 91.60 High High
Post-traumatic Stress Disorder 79 88.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Preliminary studies with microdialysis and real-time PCR analysis support this idea: local ethanol administration in vivo had no effect on glutamate release, but chronic ethanol nearly tripled the expression of NR2B subunits (the most ethanol sensitive) in CeA.
Positive_regulation (tripled) of Gene_expression (expression) of CeA in CeA associated with glutamate and amygdala
1) Confidence 0.47 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 14684447 Disease Relevance 0.07 Pain Relevance 0.98
Recently, we reported that intraplantar (i.pl.) injection of formalin as a chemical somatic noxious stimulus increased c-fos mRNA expression in the BLA, but not CeA, while intraperitoneal (i.p.) injection of acetic acid as a chemical visceral noxious stimulus induced it highly in the CeA, and hardly in BLA [Nakagawa et al. (2003) Neurosci.
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of CeA in visceral
2) Confidence 0.44 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622196 Disease Relevance 0.23 Pain Relevance 0.31
Infusion of PACAP into CeA resulted in no
Neg (no) Positive_regulation (resulted) of Gene_expression (Infusion) of CeA associated with amygdala
3) Confidence 0.42 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.75 Pain Relevance 0.33
substantial effects of PACAP microinjection into the CeA on the expression of
Positive_regulation (effects) of Gene_expression (microinjection) of CeA associated with amygdala
4) Confidence 0.42 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.70 Pain Relevance 0.35
Intra-CeA PACAP injection does not alter exploration of the
Positive_regulation (-) of Gene_expression (injection) of CeA associated with amygdala
5) Confidence 0.42 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.50 Pain Relevance 0.34
Intra-CeA PACAP infusion reduces number of shocks without
Positive_regulation (-) of Gene_expression (infusion) of CeA associated with shock and amygdala
6) Confidence 0.42 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.50 Pain Relevance 0.28
No intra-CeA PACAP injection effects were found in animals tested with the
Neg (No) Positive_regulation (-) of Gene_expression (injection) of CeA associated with amygdala
7) Confidence 0.42 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 0.47 Pain Relevance 0.34
velocity of movement were reduced in intra-CeA PACAP-injected animals tested
Positive_regulation (-) of Gene_expression (injected) of CeA associated with amygdala
8) Confidence 0.42 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 1.22 Pain Relevance 0.37
The Expression of Corticotropin-Releasing Factor in the Central Nucleus of the Amygdala, Induced by Colorectal Distension, is Attenuated by General Anesthesia

Corticotrophin-releasing factor (CRF), a key regulator of the hypothalamic-pituitary axis, is expressed in the central nucleus of the amygdala (CeA) and its expression is upregulated in stress-related disorders.

Positive_regulation (upregulated) of in Nucleus Gene_expression (expression) of CeA in amygdala associated with stress, anesthesia and amygdala
9) Confidence 0.41 Published 2010 Journal Journal of Korean Medical Science Section Title Doc Link PMC2967003 Disease Relevance 0.35 Pain Relevance 0.80
Taken together, these results indicate that chronic treatment with morphine upregulates functional DORs in neurons projecting from the CeA to periaqueductal grey.
Positive_regulation (upregulates) of Gene_expression (projecting) of CeA in CeA associated with periaqueductal grey, delta opioid receptors, amygdala and morphine
10) Confidence 0.41 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19580818 Disease Relevance 0.49 Pain Relevance 1.88
Our results demonstrate that the level of consciousness may affect the expression of CRF and pERK in the CeA induced by visceral pain.
Positive_regulation (induced) of Gene_expression (expression) of CeA in visceral associated with visceral pain and amygdala
11) Confidence 0.39 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967003 Disease Relevance 0.31 Pain Relevance 1.25
Previous animal studies have suggested that exposures to psychological and physiological stresses immediately increase CRF expression in the CeA (29, 30).
Positive_regulation (increase) of Gene_expression (expression) of CeA associated with stress and amygdala
12) Confidence 0.39 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967003 Disease Relevance 0.67 Pain Relevance 0.83
Indeed, our results indicated that intra-CeA microinfusion of PACAP (50 or 100 pmol) enhanced certain types of aversive behaviors in the shock-probe fear test, consistent with our notion that PACAPergic neurotransmission may be linked to manifestations of stress and fear

(Agarwal et al. [8];

Positive_regulation (enhanced) of Gene_expression (microinfusion) of CeA associated with stress, anxiety disorder, shock and amygdala
13) Confidence 0.37 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1906870 Disease Relevance 1.32 Pain Relevance 0.29
The BST and CeA also express more DA D1 receptors and tyrosine hydroxylase (TH) immunoreactivity than the mPOA or VMH in adulthood [46], [47].
Positive_regulation (more) of Gene_expression (express) of CeA associated with dopamine and amygdala
14) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2359852 Disease Relevance 0.08 Pain Relevance 0.65
Interestingly, neonatal treatment with the D1-like agonist increased PR expression only within the central amygdala (CeA) and the bed nucleus of the stria terminalis (BST) of the developing female rat brain and these increases were blocked by an ER antagonist [15], which is consistent with PR dependence upon ER expression in developing brain [16].
Positive_regulation (increased) of Gene_expression (expression) of CeA in brain associated with addiction, antagonist, agonist and amygdala
15) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2359852 Disease Relevance 0 Pain Relevance 0.68
The ability of PSK 3668 to block SKF 38393-induced Fos within these regions suggests that ER-mediated DA action might contribute to sex differences in Fos expression within the BST and CeA.
Spec (might) Positive_regulation (contribute) of Gene_expression (expression) of CeA associated with dopamine and amygdala
16) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2359852 Disease Relevance 0 Pain Relevance 0.39
separate portions of the CeA-PAG pathway mediate the stress induced changes in startle amplitude and startle
Positive_regulation (portions) of Gene_expression (pathway) of CeA associated with stress, central grey and amygdala
17) Confidence 0.19 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.09 Pain Relevance 0.43
We transfected the neurons of the right PAG in an area where pCREB levels and CeA-PAG transmission are elevated after predator
Positive_regulation (elevated) of Gene_expression (transmission) of CeA in neurons associated with central grey
18) Confidence 0.19 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.12 Pain Relevance 0.34
separate portions of the CeA-PAG pathway mediate the stress induced changes in startle amplitude and startle
Positive_regulation (-) of Gene_expression (pathway) of CeA associated with stress, central grey and amygdala
19) Confidence 0.19 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.09 Pain Relevance 0.43
We transfected the neurons of the right PAG in an area where pCREB levels and CeA-PAG transmission are elevated after predator
Positive_regulation (-) of Gene_expression (transmission) of CeA in neurons associated with central grey
20) Confidence 0.19 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.12 Pain Relevance 0.34

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