INT114586

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Context Info
Confidence 0.17
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.07
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Il1rap) intracellular (Il1rap) protein binding, bridging (Il1rap)
protein complex (Il1rap) signal transducer activity (Il1rap)
Anatomy Link Frequency
sensory neurons 2
neurons 2
Il1rap (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 24 96.72 Very High Very High Very High
antagonist 2 90.12 High High
Pain 4 80.72 Quite High
spinal dorsal horn 2 70.60 Quite High
Disease Link Frequency Relevance Heat
Pain 4 69.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment of DRG neurons in culture with herbimycin A, genistein or PP2, three structurally different nonreceptor tyrosine kinase inhibitors that act by different mechanisms, decreased the kinase activity of p60c-src induced by the activation of IL-1 receptor.
Positive_regulation (induced) of Positive_regulation (activation) of IL-1 receptor in neurons
1) Confidence 0.17 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622206 Disease Relevance 0.07 Pain Relevance 0.42
These findings show that phosphorylation of specific protein tyrosine residue(s) following IL-1 receptor activation might play a key role in IL-1beta signalling to modulate PPT gene expression and SP secretion in sensory neurons.
Positive_regulation (following) of Positive_regulation (activation) of IL-1 receptor in sensory neurons associated with substance p
2) Confidence 0.17 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622206 Disease Relevance 0 Pain Relevance 0.46

General Comments

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