INT114627

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Context Info
Confidence 0.70
First Reported 2003
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 6.41
Pain Relevance 5.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpv2) intracellular (Trpv2) transmembrane transport (Trpv2)
cytoplasm (Trpv2)
Anatomy Link Frequency
nerve 4
neurons 4
dorsal root ganglia 4
plasma 2
Trpv2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 4 99.98 Very High Very High Very High
Inflammation 51 99.90 Very High Very High Very High
dorsal root ganglion 9 99.68 Very High Very High Very High
neuralgia 8 99.30 Very High Very High Very High
TRP channel 3 97.72 Very High Very High Very High
allodynia 1 97.24 Very High Very High Very High
Hyperalgesia 16 96.68 Very High Very High Very High
ASIC 2 94.12 High High
antagonist 2 92.88 High High
Root ganglion neuron 4 91.76 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 36 99.90 Very High Very High Very High
Ganglion Cysts 13 99.68 Very High Very High Very High
Nervous System Injury 3 98.92 Very High Very High Very High
Neuropathic Pain 1 97.24 Very High Very High Very High
Hyperalgesia 21 96.68 Very High Very High Very High
Injury 7 75.24 Quite High
Targeted Disruption 1 75.00 Quite High
Neuroblastoma 2 74.28 Quite High
Peripheral Neuropathy 1 68.76 Quite High
Hypersensitivity 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunofluorescence analysis of the endogenous VRL-1 in F-11 cells gives only weak signals in the cytoplasm whereas the overexpressed rat VRL-1 appears mainly at the plasma membrane.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of VRL-1 in plasma
1) Confidence 0.70 Published 2003 Journal Eur. J. Biochem. Section Abstract Doc Link 14622291 Disease Relevance 0.27 Pain Relevance 0.16
Intraplantar injection of nerve growth factor increased TRPV1 expression but not TRPV2, suggesting that induction of TRPV2 expression is driven by a mechanism distinct from that for TRPV1.
Positive_regulation (induction) of Gene_expression (expression) of TRPV2 in nerve associated with nerve growth factor
2) Confidence 0.70 Published 2005 Journal Pain Section Abstract Doc Link 16298071 Disease Relevance 0.75 Pain Relevance 0.62
Intraplantar injection of nerve growth factor increased TRPV1 expression but not TRPV2, suggesting that induction of TRPV2 expression is driven by a mechanism distinct from that for TRPV1.
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of TRPV2 in nerve associated with nerve growth factor
3) Confidence 0.70 Published 2005 Journal Pain Section Abstract Doc Link 16298071 Disease Relevance 0.75 Pain Relevance 0.61
Peripheral inflammation induces up-regulation of TRPV2 expression in rat DRG.
Positive_regulation (regulation) of Gene_expression (expression) of TRPV2 associated with inflammation
4) Confidence 0.70 Published 2005 Journal Pain Section Title Doc Link 16298071 Disease Relevance 0.69 Pain Relevance 0.88
Expressions of TRPV2, P2X(3), and ASIC3 increased in all DRG neurons.
Positive_regulation (increased) of Gene_expression (Expressions) of TRPV2 in neurons associated with dorsal root ganglion
5) Confidence 0.62 Published 2010 Journal Pain Section Abstract Doc Link 20378247 Disease Relevance 0.92 Pain Relevance 1.00
In contrast to the endogenous VRL-1 the overexpressed protein is glycosylated.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of VRL-1
6) Confidence 0.50 Published 2003 Journal Eur. J. Biochem. Section Abstract Doc Link 14622291 Disease Relevance 0.30 Pain Relevance 0.18
Using specific antibodies, an increase in TRPV2-expressing neurons was identified after inflammation.
Positive_regulation (increase) of Gene_expression (expressing) of TRPV2-expressing in neurons associated with inflammation
7) Confidence 0.50 Published 2005 Journal Pain Section Abstract Doc Link 16298071 Disease Relevance 0.64 Pain Relevance 0.43
Increased TRPA1, TRPM8, and TRPV2 expression in dorsal root ganglia by nerve injury.
Positive_regulation (Increased) of Gene_expression (expression) of TRPV2 in dorsal root ganglia associated with nervous system injury
8) Confidence 0.47 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 17517374 Disease Relevance 0.47 Pain Relevance 0.37
By contrast, HPL at 56 degrees C was not shortened after forepaw inflammation and expression of TRPV2, a TRPV1 homolog, in the DRG was not increased.
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of TRPV2 in DRG associated with inflammation
9) Confidence 0.41 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17509082 Disease Relevance 1.62 Pain Relevance 0.92

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