INT114642

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Context Info
Confidence 0.57
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 2.32
Pain Relevance 6.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Creb1) mitochondrion (Creb1) nucleolus (Creb1)
nucleus (Creb1) DNA binding (Creb1) transcription factor binding (Creb1)
Anatomy Link Frequency
spinal cord 6
neurons 2
dorsal horn 2
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 18 100.00 Very High Very High Very High
dorsal root ganglion 6 100.00 Very High Very High Very High
spinal dorsal horn 12 99.84 Very High Very High Very High
long-term potentiation 12 99.70 Very High Very High Very High
antagonist 6 99.56 Very High Very High Very High
withdrawal 12 99.52 Very High Very High Very High
Morphine 85 99.30 Very High Very High Very High
Kinase C 9 98.12 Very High Very High Very High
central sensitization 6 95.04 Very High Very High Very High
Spinal cord 22 93.84 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 12 100.00 Very High Very High Very High
Apoptosis 29 99.52 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 1 89.28 High High
Death 19 88.76 High High
Neurodegenerative Disease 4 85.76 High High
Hypoxia 2 85.76 High High
Stress 9 83.84 Quite High
Nervous System Injury 3 76.56 Quite High
Neuropathic Pain 7 75.52 Quite High
Pain 3 75.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We hypothesize that the decrease in phospho-Thr34 DARPP-32 could evoke an increase in PP-1 activity which is responsible for the reduction of CREB activation.
Negative_regulation (reduction) of Positive_regulation (activation) of CREB
1) Confidence 0.57 Published 2007 Journal Brain Res. Section Abstract Doc Link 17125745 Disease Relevance 0 Pain Relevance 0.63
More importantly, we found that spinal application of PD 98059 (100 microM), a selective MEK inhibitor, at 30 min before tetanic stimulation blocked LTP induction and prevented the increase in p-ERK and p-CREB in spinal dorsal horn.
Negative_regulation (prevented) of Positive_regulation (increase) of p-CREB in dorsal horn associated with spinal dorsal horn and long-term potentiation
2) Confidence 0.48 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16902997 Disease Relevance 0.07 Pain Relevance 1.02
The results indicate that PKC mediates both CREB activation and HPA response by morphine withdrawal and might suggest that CREB activation in the NTS is related to TH expression associated with morphine withdrawal.
Negative_regulation (related) of Positive_regulation (activation) of CREB associated with kinase c, withdrawal and morphine
3) Confidence 0.42 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19545278 Disease Relevance 0.15 Pain Relevance 1.05
These measurements showed that estradiol increased phosphorylation of CREB (cyclic AMP response-element binding protein), which was consistently blocked by the ERK pathway inhibitor PD98059 but not by the inhibitors of phosphatidylinositol 3-kinase, wortmannin and LY294002. 17beta-Estradiol activation of CREB in DRG neurons was reduced by the ER antagonist, ICI182780.
Negative_regulation (reduced) of Positive_regulation (activation) of CREB in neurons associated with dorsal root ganglion and antagonist
4) Confidence 0.41 Published 2004 Journal Neuroscience Section Abstract Doc Link 15541884 Disease Relevance 0.84 Pain Relevance 0.40
Combined application of the ERK1/2 and CaMKII inhibitors also attenuated the ligation-associated CREB activation but not to a greater extent than either inhibitor alone.
Negative_regulation (attenuated) of Positive_regulation (activation) of CREB
5) Confidence 0.39 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15882794 Disease Relevance 0.21 Pain Relevance 0.47
The level of p-CREB increased by 20 minutes, peaked between 20 and 60 minutes after capsaicin injection, and started to decrease after 150 minutes.
Negative_regulation (decrease) of Positive_regulation (increased) of p-CREB associated with qutenza
6) Confidence 0.38 Published 2002 Journal J Pain Section Abstract Doc Link 14622772 Disease Relevance 0 Pain Relevance 0.81
The increase in p-CREB induced by capsaicin injection was partially blocked by pretreatment with N(G)-nitro-L-arginine methyl ester (L-NAME), an NO synthase inhibitor, administered through a microdialysis fiber placed across the spinal cord.
Negative_regulation (blocked) of Positive_regulation (increase) of p-CREB in spinal cord associated with qutenza and spinal cord
7) Confidence 0.38 Published 2002 Journal J Pain Section Abstract Doc Link 14622772 Disease Relevance 0 Pain Relevance 0.89
The increase in p-CREB induced by capsaicin injection was partially blocked by pretreatment with N(G)-nitro-L-arginine methyl ester (L-NAME), an NO synthase inhibitor, administered through a microdialysis fiber placed across the spinal cord.
Negative_regulation (blocked) of Positive_regulation (induced) of p-CREB in spinal cord associated with qutenza and spinal cord
8) Confidence 0.38 Published 2002 Journal J Pain Section Abstract Doc Link 14622772 Disease Relevance 0 Pain Relevance 0.89
The increase in pCREB was partially reversed by the blockade of the cAMP pathway in the early 3 days, with a parallel increase in mechanical and thermal withdrawal thresholds.
Negative_regulation (reversed) of Positive_regulation (increase) of pCREB
9) Confidence 0.37 Published 2007 Journal Anesth. Analg. Section Body Doc Link 18042889 Disease Relevance 0.22 Pain Relevance 0
Intrathecal injection of U0126 or ERK antisense ODN markedly suppressed the increase of CCI-induced pERK, pCREB and c-Fos expression in the spinal cord.
Negative_regulation (suppressed) of Positive_regulation (increase) of pCREB in spinal cord
10) Confidence 0.35 Published 2005 Journal Acta Pharmacol. Sin. Section Body Doc Link 15960884 Disease Relevance 0 Pain Relevance 0
Determination of CREB activation
Negative_regulation (Determination) of Positive_regulation (activation) of CREB
11) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2628740 Disease Relevance 0 Pain Relevance 0.59
B, and
               3) WOX1 functional augmentation in apoptosis is observed due to its suppression of
               CREB transcriptional activation.
Negative_regulation (suppression) of Positive_regulation (activation) of CREB associated with apoptosis
12) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771921 Disease Relevance 0.84 Pain Relevance 0

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