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Context Info
Confidence 0.70
First Reported 2003
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.27
Pain Relevance 1.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Map4) cytoskeleton (Map4) cytoplasm (Map4)
Anatomy Link Frequency
juvenile 1
hippocampus 1
Map4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
long-term potentiation 5 100.00 Very High Very High Very High
antagonist 4 100.00 Very High Very High Very High
Glutamate receptor 3 100.00 Very High Very High Very High
Neuropeptide 2 100.00 Very High Very High Very High
antidepressant 4 98.64 Very High Very High Very High
medulla 1 98.12 Very High Very High Very High
agonist 2 97.92 Very High Very High Very High
Hippocampus 2 97.72 Very High Very High Very High
Kinase C 3 91.80 High High
depression 1 88.56 High High
Disease Link Frequency Relevance Heat
Stress 2 96.52 Very High Very High Very High
Depression 1 88.56 High High
Nociception 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Up-regulation of microtubule-associated protein 4 and drebrin A mRNA expression by antidepressants in rat hippocampus following chronic stress.
Positive_regulation (Up-regulation) of microtubule-associated protein 4 in hippocampus associated with stress, antidepressant, neuropeptide and hippocampus
1) Confidence 0.70 Published 2003 Journal Neurosci. Lett. Section Title Doc Link 14623141 Disease Relevance 0.19 Pain Relevance 0.70
Using both extracellular field potential and whole-cell patch-clamp recordings in brainstem parasagital slices of juvenile rat with the mandibular nerve attached, we show here that the induction of trigeminal primary afferent LTP: (1) does not require the activation of ionotropic glutamate receptors; (2) is dependent on extracellular Ca(2+) and the release of Ca(2+) from intracellular stores; (3) is specifically prevented by the metabotropic glutamate receptor subtype 5 (mGluR5) antagonist 2-methyl-6-(phenylethynyl)pyridine but not the mGluR1 antagonist LY367385, group II mGluR antagonist LY341495 or group III mGluR antagonist MAP4; (4) is mimicked by the bath-applied group I mGluR agonist (S)-3,5-dihydroxyphenylglycine and mGluR5 agonist (RS)-2-chloro-5-hydroxyphenylglycine; (5) requires the activation of phospholipase C (PLC) and protein kinase C (PKC); and (6) is concomitantly with a decrease in paired-pulse depression.
Positive_regulation (induction) of MAP4 in juvenile associated with medulla, kinase c, depression, antagonist, glutamate receptor, agonist and long-term potentiation
2) Confidence 0.50 Published 2005 Journal Pain Section Abstract Doc Link 15777867 Disease Relevance 0.09 Pain Relevance 0.90

General Comments

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