INT114664

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Context Info
Confidence 0.37
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 6.54
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (BMP2) growth (BMP2) extracellular region (BMP2)
embryo development (BMP2) protein complex (BMP2) cell-cell signaling (BMP2)
Anatomy Link Frequency
spinal 1
spine 1
posterior 1
crest 1
BMP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
backache 1 94.84 High High
Infliximab 2 90.80 High High
Facet joint 1 87.60 High High
spinal inflammation 8 87.32 High High
Osteoarthritis 88 83.60 Quite High
Sciatica 3 75.04 Quite High
bDMF 24 72.20 Quite High
Root ganglion neuron 2 58.88 Quite High
Arthritis 16 50.00 Quite Low
Pain 21 44.00 Quite Low
Disease Link Frequency Relevance Heat
Cancer 5 99.00 Very High Very High Very High
Malignant Neoplastic Disease 24 97.68 Very High Very High Very High
Osteoporosis 58 97.52 Very High Very High Very High
Bone Fracture 5 96.16 Very High Very High Very High
Low Back Pain 10 94.84 High High
Disease 43 94.72 High High
Injury 82 93.56 High High
Metabolic Disorder 9 87.16 High High
Fracture Healing 131 86.32 High High
Pressure Volume 2 Under Development 17 84.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bone grafting was done with local autologous or allograft bone, augmented with recombinant human bone morphogenetic protein-2 in some cases.
bone morphogenetic protein-2 Binding (augmented) of
1) Confidence 0.37 Published 2005 Journal J Spinal Disord Tech Section Abstract Doc Link 15699793 Disease Relevance 0.43 Pain Relevance 0.18
Association between two SNPs of BMP-2 gene and OPLL is firstly reported in the paper.


BMP-2 gene Binding (Association) of
2) Confidence 0.35 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2443260 Disease Relevance 0.85 Pain Relevance 0.04
Collagen sponges for bone regeneration with rhBMP-2.
rhBMP-2 Binding (regeneration) of
3) Confidence 0.31 Published 2003 Journal Adv. Drug Deliv. Rev. Section Title Doc Link 14623404 Disease Relevance 0.19 Pain Relevance 0.09
Bone Morphogenetic Protein 2 (BMP2) and TGF?
Morphogenetic Protein 2 Binding (Bone) of
4) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0.20 Pain Relevance 0.10
Bone Morphogenetic Protein 2 (BMP2) and TGF?
BMP2 Binding (Bone) of
5) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0.20 Pain Relevance 0.10
In several preclinical studies, a single percutaneous injection of recombinant human BMP-2 (rhBMP-2) in a calcium phosphate paste (alpha bone substitute material [?
human BMP-2 Binding (recombinant) of
6) Confidence 0.28 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721393 Disease Relevance 0.30 Pain Relevance 0
With these conflicting reports, rhBMP-2 should not be implanted at the site of resected tumor or in patients with active malignancy.


rhBMP-2 Binding (implanted) of associated with malignant neoplastic disease and cancer
7) Confidence 0.28 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721393 Disease Relevance 1.02 Pain Relevance 0
In several preclinical studies, a single percutaneous injection of recombinant human BMP-2 (rhBMP-2) in a calcium phosphate paste (alpha bone substitute material [?
rhBMP-2 Binding (recombinant) of
8) Confidence 0.28 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721393 Disease Relevance 0.30 Pain Relevance 0
Thirty patients were randomly enrolled in one of two groups: 1) control group with autogenous iliac crest bone graft, 2) treatment group with cancellous allograft with rhBMP-2/ACS.
rhBMP-2 Binding (allograft) of in crest
9) Confidence 0.28 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721393 Disease Relevance 0.72 Pain Relevance 0
Association of bone morphogenetic protein-2 gene polymorphisms with susceptibility to ossification of the posterior longitudinal ligament of the spine and its severity in Chinese patients

A case–control study was conducted to examine the association between two single nucleotide polymorphisms (SNPs) in exon 2 of the bone morphogenetic protein-2 gene (BMP-2) and ossification of the posterior longitudinal ligament (OPLL), and to investigate whether SNPs of the Ser37Ala (T/G) and the Ser87Ser (A/G) in the BMP-2 gene are associated with genetic susceptibility to OPLL and its severity in Chinese subjects.

bone morphogenetic protein-2 gene Binding (Association) of in posterior associated with genetic predisposition to disease
10) Confidence 0.27 Published 2008 Journal Eur Spine J Section Title Doc Link PMC2443260 Disease Relevance 0.22 Pain Relevance 0
The purpose of this study was to investigate association of two SNPs of BMP-2 gene with susceptibility to OPLL of the spine and its severity in Chinese patients.
BMP-2 gene Binding (association) of in spine
11) Confidence 0.26 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2443260 Disease Relevance 0.87 Pain Relevance 0.04
Currently, only two BMPs produced using recombinant gene technology have been commercialized: BMP-2 (Infuse®, Medtronic Sofamor, Minneapolis, MN, USA) and BMP-7 (OP-1®, Stryker Biotech, West Chester, PA, USA); and these are limited to approved applications in trauma and spinal fusion [12].
BMP-2 Binding (commercialized) of in spinal associated with injury
12) Confidence 0.18 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2887894 Disease Relevance 0.38 Pain Relevance 0
Type IIA procollagen contains an additional 69 amino acid cysteine-rich domain in the N-propeptide that binds bone morphogenetic protein 2 and that has been hypothesized to play a role in chondrogenesis (Zhu et al. 1999).
bone morphogenetic protein 2 Binding (binds) of
13) Confidence 0.04 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716783 Disease Relevance 0.86 Pain Relevance 0.36

General Comments

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