INT114672

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Context Info
Confidence 0.09
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.51
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

p53-ps (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 5 76.24 Quite High
Thalamus 2 75.20 Quite High
Morphine 6 75.00 Quite High
cocaine 3 75.00 Quite High
amygdala 2 74.40 Quite High
Central grey 1 73.60 Quite High
Locus ceruleus 1 71.68 Quite High
addiction 2 25.00 Low Low
antagonist 8 16.32 Low Low
cerebral cortex 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 76 98.60 Very High Very High Very High
Neurodegenerative Disease 9 91.68 High High
Aids-related Complex 22 90.72 High High
Repression 3 75.92 Quite High
Urological Neuroanatomy 1 73.60 Quite High
Suicidal Behaviour 27 50.00 Quite Low
Targeted Disruption 10 39.52 Quite Low
Death 17 5.00 Very Low Very Low Very Low
Body Weight 17 5.00 Very Low Very Low Very Low
Obesity 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our present study investigated the effects of treatments with different addictive drugs on gene expression of murine double minute clone 2 (MDM2), a key negative regulator of p53 and an important mediator in cell apoptosis.
Negative_regulation (regulator) of p53 associated with apoptosis
1) Confidence 0.09 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14625023 Disease Relevance 0.26 Pain Relevance 0.48
Fasting induced decrease in p53 acetylation [10] was also reversed by inhibition of Sirt1 function, and Stat3 acetylation was insensitive to Sirt1 inhibition (data not shown).
Negative_regulation (decrease) of p53
2) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.17 Pain Relevance 0
One hypothesis that remains to be tested, is that estrogen receptors and p53 may be mutually repressive.
Negative_regulation (repressive) of p53
3) Confidence 0.06 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.08 Pain Relevance 0

General Comments

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