INT114673

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Context Info
Confidence 0.62
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.23
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mdm2) intracellular (Mdm2) enzyme binding (Mdm2)
protein complex assembly (Mdm2) protein complex (Mdm2) cytoplasm (Mdm2)
Anatomy Link Frequency
brain 2
Mdm2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 3 96.60 Very High Very High Very High
Morphine 6 95.80 Very High Very High Very High
addiction 1 95.28 Very High Very High Very High
Thalamus 2 92.96 High High
Hippocampus 3 91.68 High High
amygdala 2 76.48 Quite High
Locus ceruleus 1 72.24 Quite High
Central grey 1 71.48 Quite High
Disease Link Frequency Relevance Heat
Drug Dependence 1 95.48 Very High Very High Very High
Urological Neuroanatomy 1 71.48 Quite High
Apoptosis 1 59.28 Quite High
Neurodegenerative Disease 1 48.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus we demonstrated for the first time that the administration of addictive drugs regulate MDM2 gene expression in distinct rat brain regions and these data suggest that MDM2 may play an important role in the development of drug addiction.
Regulation (regulate) of Gene_expression (expression) of MDM2 gene in brain associated with drug dependence and addiction
1) Confidence 0.62 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14625023 Disease Relevance 0.23 Pain Relevance 1.02

General Comments

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