INT114674

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Context Info
Confidence 0.78
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 3.51
Pain Relevance 11.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mdm2) intracellular (Mdm2) enzyme binding (Mdm2)
protein complex assembly (Mdm2) protein complex (Mdm2) cytoplasm (Mdm2)
Anatomy Link Frequency
brain 5
hippocampus 3
amygdala 2
cortex 2
neurons 1
Mdm2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 42 99.84 Very High Very High Very High
Morphine 84 99.76 Very High Very High Very High
amygdala 28 99.12 Very High Very High Very High
cocaine 42 99.10 Very High Very High Very High
Locus ceruleus 14 98.52 Very High Very High Very High
Central grey 14 97.76 Very High Very High Very High
Thalamus 28 96.88 Very High Very High Very High
addiction 14 95.28 Very High Very High Very High
tetrodotoxin 4 5.00 Very Low Very Low Very Low
Glutamate receptor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 14 99.40 Very High Very High Very High
Urological Neuroanatomy 14 97.76 Very High Very High Very High
Drug Dependence 14 95.48 Very High Very High Very High
Neurodegenerative Disease 14 95.28 Very High Very High Very High
Angelman Syndrome 1 8.48 Low Low
Syndrome 2 7.48 Low Low
Intellectual Impairment 1 7.12 Low Low
Anxiety Disorder 1 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 1 5.00 Very Low Very Low Very Low
Cognitive Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus we demonstrated for the first time that the administration of addictive drugs regulate MDM2 gene expression in distinct rat brain regions and these data suggest that MDM2 may play an important role in the development of drug addiction.
Gene_expression (expression) of MDM2 gene in brain associated with drug dependence and addiction
1) Confidence 0.78 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14625023 Disease Relevance 0.23 Pain Relevance 1.02
Acute heroin or cocaine administration also significantly increased MDM2 gene expression in hippocampus, but not in cortex.
Gene_expression (expression) of MDM2 gene in hippocampus associated with hippocampus and cocaine
2) Confidence 0.78 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14625023 Disease Relevance 0.21 Pain Relevance 1.08
After a single morphine injection, MDM2 gene expression increased significantly in hippocampus, amygdala and cortex; however, such up-regulation of MDM2 gene expression was significantly reduced after repeated morphine administration.
Gene_expression (expression) of MDM2 gene in cortex associated with hippocampus, amygdala and morphine
3) Confidence 0.78 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14625023 Disease Relevance 0.26 Pain Relevance 0.99
After a single morphine injection, MDM2 gene expression increased significantly in hippocampus, amygdala and cortex; however, such up-regulation of MDM2 gene expression was significantly reduced after repeated morphine administration.
Gene_expression (expression) of MDM2 gene in cortex associated with hippocampus, amygdala and morphine
4) Confidence 0.78 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14625023 Disease Relevance 0.24 Pain Relevance 1.03
The level of MDM2 gene expression in rat brain was assessed using in situ hybridization histochemistry.
Gene_expression (expression) of MDM2 gene in brain
5) Confidence 0.78 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14625023 Disease Relevance 0.27 Pain Relevance 0.57
In normal adult rat brain, MDM2 expression was at a very low level but MDM2 mRNA-positive cells were detected in various regions including cortex, hippocampus, thalamus, amygdala, periaqueductal gray and locus ceruleus.
Gene_expression (expression) of MDM2 in brain associated with locus ceruleus, thalamus, hippocampus, central grey and amygdala
6) Confidence 0.78 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14625023 Disease Relevance 0.27 Pain Relevance 0.73
Up-regulation of murine double minute clone 2 (MDM2) gene expression in rat brain after morphine, heroin, and cocaine administrations.
Gene_expression (expression) of MDM2 in brain associated with cocaine and morphine
7) Confidence 0.60 Published 2003 Journal Neurosci. Lett. Section Title Doc Link 14625023 Disease Relevance 0.25 Pain Relevance 0.72
Our present study investigated the effects of treatments with different addictive drugs on gene expression of murine double minute clone 2 (MDM2), a key negative regulator of p53 and an important mediator in cell apoptosis.
Gene_expression (expression) of MDM2 associated with apoptosis
8) Confidence 0.60 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14625023 Disease Relevance 0.26 Pain Relevance 0.47
Our present study investigated the effects of treatments with different addictive drugs on gene expression of murine double minute clone 2 (MDM2), a key negative regulator of p53 and an important mediator in cell apoptosis.
Gene_expression (expression) of double minute clone 2 associated with apoptosis
9) Confidence 0.53 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14625023 Disease Relevance 0.26 Pain Relevance 0.47
Up-regulation of murine double minute clone 2 (MDM2) gene expression in rat brain after morphine, heroin, and cocaine administrations.
Gene_expression (expression) of double minute clone 2 in brain associated with cocaine and morphine
10) Confidence 0.53 Published 2003 Journal Neurosci. Lett. Section Title Doc Link 14625023 Disease Relevance 0.25 Pain Relevance 0.72
After a single morphine injection, MDM2 gene expression increased significantly in hippocampus, amygdala and cortex; however, such up-regulation of MDM2 gene expression was significantly reduced after repeated morphine administration.
Gene_expression (expression) of MDM2 gene in hippocampus associated with hippocampus, amygdala and morphine
11) Confidence 0.26 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14625023 Disease Relevance 0.26 Pain Relevance 0.99
After a single morphine injection, MDM2 gene expression increased significantly in hippocampus, amygdala and cortex; however, such up-regulation of MDM2 gene expression was significantly reduced after repeated morphine administration.
Gene_expression (expression) of MDM2 gene in hippocampus associated with hippocampus, amygdala and morphine
12) Confidence 0.26 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14625023 Disease Relevance 0.24 Pain Relevance 1.03
After a single morphine injection, MDM2 gene expression increased significantly in hippocampus, amygdala and cortex; however, such up-regulation of MDM2 gene expression was significantly reduced after repeated morphine administration.
Gene_expression (expression) of MDM2 gene in amygdala associated with hippocampus, amygdala and morphine
13) Confidence 0.26 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14625023 Disease Relevance 0.26 Pain Relevance 0.99
After a single morphine injection, MDM2 gene expression increased significantly in hippocampus, amygdala and cortex; however, such up-regulation of MDM2 gene expression was significantly reduced after repeated morphine administration.
Gene_expression (expression) of MDM2 gene in amygdala associated with hippocampus, amygdala and morphine
14) Confidence 0.26 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14625023 Disease Relevance 0.24 Pain Relevance 1.03
With RNAi pools targeting E6-AP/Ube3A or Mdm2, only a small number of transfected neurons could be identified, all of which appeared unhealthy; thus, these were excluded from further analysis (data not shown).
Gene_expression (targeting) of Mdm2 in neurons
15) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844417 Disease Relevance 0 Pain Relevance 0

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