INT114675

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Context Info
Confidence 0.70
First Reported 2003
Last Reported 2003
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 8
Disease Relevance 1.98
Pain Relevance 7.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mdm2) intracellular (Mdm2) enzyme binding (Mdm2)
protein complex assembly (Mdm2) protein complex (Mdm2) cytoplasm (Mdm2)
Anatomy Link Frequency
cortex 8
hippocampus 4
brain 2
amygdala 2
Mdm2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 24 99.84 Very High Very High Very High
Morphine 48 99.76 Very High Very High Very High
amygdala 16 99.46 Very High Very High Very High
cocaine 24 99.30 Very High Very High Very High
Locus ceruleus 8 98.52 Very High Very High Very High
Central grey 8 97.76 Very High Very High Very High
Thalamus 16 96.88 Very High Very High Very High
addiction 8 70.40 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 8 97.76 Very High Very High Very High
Neurodegenerative Disease 8 95.28 Very High Very High Very High
Apoptosis 8 85.56 High High
Drug Dependence 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acute heroin or cocaine administration also significantly increased MDM2 gene expression in hippocampus, but not in cortex.
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of MDM2 gene in hippocampus associated with hippocampus and cocaine
1) Confidence 0.70 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14625023 Disease Relevance 0.21 Pain Relevance 1.09
After a single morphine injection, MDM2 gene expression increased significantly in hippocampus, amygdala and cortex; however, such up-regulation of MDM2 gene expression was significantly reduced after repeated morphine administration.
Positive_regulation (increased) of Gene_expression (expression) of MDM2 gene in cortex associated with hippocampus, amygdala and morphine
2) Confidence 0.70 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14625023 Disease Relevance 0.26 Pain Relevance 1.00
After a single morphine injection, MDM2 gene expression increased significantly in hippocampus, amygdala and cortex; however, such up-regulation of MDM2 gene expression was significantly reduced after repeated morphine administration.
Positive_regulation (up-regulation) of Gene_expression (expression) of MDM2 gene in cortex associated with hippocampus, amygdala and morphine
3) Confidence 0.70 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14625023 Disease Relevance 0.25 Pain Relevance 1.03
Up-regulation of murine double minute clone 2 (MDM2) gene expression in rat brain after morphine, heroin, and cocaine administrations.
Positive_regulation (Up-regulation) of Gene_expression (expression) of MDM2 in brain associated with cocaine and morphine
4) Confidence 0.47 Published 2003 Journal Neurosci. Lett. Section Title Doc Link 14625023 Disease Relevance 0.25 Pain Relevance 0.72
After a single morphine injection, MDM2 gene expression increased significantly in hippocampus, amygdala and cortex; however, such up-regulation of MDM2 gene expression was significantly reduced after repeated morphine administration.
Positive_regulation (increased) of in hippocampus Gene_expression (expression) of MDM2 gene in cortex associated with hippocampus, amygdala and morphine
5) Confidence 0.24 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14625023 Disease Relevance 0.26 Pain Relevance 1.00
After a single morphine injection, MDM2 gene expression increased significantly in hippocampus, amygdala and cortex; however, such up-regulation of MDM2 gene expression was significantly reduced after repeated morphine administration.
Positive_regulation (up-regulation) of in amygdala Gene_expression (expression) of MDM2 gene in cortex associated with hippocampus, amygdala and morphine
6) Confidence 0.24 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14625023 Disease Relevance 0.25 Pain Relevance 1.03
After a single morphine injection, MDM2 gene expression increased significantly in hippocampus, amygdala and cortex; however, such up-regulation of MDM2 gene expression was significantly reduced after repeated morphine administration.
Positive_regulation (up-regulation) of in hippocampus Gene_expression (expression) of MDM2 gene in cortex associated with hippocampus, amygdala and morphine
7) Confidence 0.24 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14625023 Disease Relevance 0.25 Pain Relevance 1.03
After a single morphine injection, MDM2 gene expression increased significantly in hippocampus, amygdala and cortex; however, such up-regulation of MDM2 gene expression was significantly reduced after repeated morphine administration.
Positive_regulation (increased) of in amygdala Gene_expression (expression) of MDM2 gene in cortex associated with hippocampus, amygdala and morphine
8) Confidence 0.24 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14625023 Disease Relevance 0.26 Pain Relevance 1.00

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