INT114699

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Context Info
Confidence 0.32
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.21
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Fgf1) cytoplasm (Fgf1) cytosol (Fgf1)
extracellular space (Fgf1) extracellular region (Fgf1) proteinaceous extracellular matrix (Fgf1)
Anatomy Link Frequency
satellite cells 2
bone marrow 2
neural 2
Fgf1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 17 100.00 Very High Very High Very High
ischemia 47 96.56 Very High Very High Very High
agonist 2 82.12 Quite High
anesthesia 3 68.12 Quite High
Action potential 11 5.00 Very Low Very Low Very Low
midbrain 9 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
tetrodotoxin 4 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 7 100.00 Very High Very High Very High
Diabetes Mellitus 3 98.80 Very High Very High Very High
Cv Unclassified Under Development 46 96.56 Very High Very High Very High
Stress 1 92.28 High High
Aging 4 86.76 High High
Frailty 20 86.40 High High
Wilms Tumor 1 85.76 High High
Hypertrophy 3 80.56 Quite High
Muscular Atrophy 14 74.16 Quite High
Cancer 53 70.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A study using a similar model demonstrated not only improved perfusion subsequent to bone marrow administration but also enhanced production of the angiogenic cytokines IL-1 and FGF-2 [31].
Positive_regulation (enhanced) of Gene_expression (production) of FGF in bone marrow associated with cytokine
1) Confidence 0.32 Published 2008 Journal J Transl Med Section Body Doc Link PMC2533293 Disease Relevance 0.66 Pain Relevance 0.18
In conclusion, we have identified a subset of genes with increased expression in noninfarcted left ventricular tissue following MI, including syndecans 1-4, WT-1, fibronectin, collagen 6A, and FGF receptor 1.
Positive_regulation (increased) of Gene_expression (expression) of FGF associated with myocardial infarction
2) Confidence 0.31 Published 2004 Journal Physiol. Genomics Section Abstract Doc Link 14625378 Disease Relevance 0.54 Pain Relevance 0.07
The myogenic regenerative capacity of human satellite cells isolated from both young and old subjects was significantly enhanced when ERK is activated by the presence of FGF in the culture medium.
Positive_regulation (activated) of Gene_expression (presence) of FGF in satellite cells
3) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 1.02 Pain Relevance 0.04
We noticed that expression of some FGF members (e.g., FGF8 and FGF9) was up-regulated during early neural induction from hiPSC as well hESC (Figure 1C), which led us to evaluate the role of the FGF pathway during neural induction from hiPSC.
Positive_regulation (up) of Gene_expression (expression) of FGF in neural
4) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912324 Disease Relevance 0 Pain Relevance 0

General Comments

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