INT1147

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Context Info
Confidence 0.14
First Reported 1975
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Ppa1)
Anatomy Link Frequency
duodenum 1
Ppa1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 1 100.00 Very High Very High Very High
Nicotine 8 99.84 Very High Very High Very High
anesthesia 4 96.16 Very High Very High Very High
agonist 1 91.76 High High
guanethidine 1 86.84 High High
tetrodotoxin 2 84.96 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nicotine-induced relaxation of adult duodenum was significantly inhibited by preincubation with alpha-chymotrypsin, a proteolytic enzyme, and a combination of nucleotide pyrophosphatase and 8-phenyltheophylline, a P1 purinoceptor antagonist.
Negative_regulation (antagonist) of pyrophosphatase in duodenum associated with antagonist and nicotine
1) Confidence 0.14 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8137872 Disease Relevance 0 Pain Relevance 0.64
Activity of galactosyl-transferase showed a slight gradual increase but thiamine pyrophosphatase decreased sharply, and after 24 h increased to above control level.
Negative_regulation (decreased) of pyrophosphatase
2) Confidence 0.09 Published 1975 Journal Chem. Biol. Interact. Section Abstract Doc Link 163708 Disease Relevance 0 Pain Relevance 0.31

General Comments

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