INT114702

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Context Info
Confidence 0.74
First Reported 2001
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 34
Total Number 35
Disease Relevance 17.39
Pain Relevance 2.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Fgf1) cytoplasm (Fgf1) cytosol (Fgf1)
extracellular space (Fgf1) extracellular region (Fgf1) proteinaceous extracellular matrix (Fgf1)
Anatomy Link Frequency
fibroblast 6
brain 4
pituitary 3
HGF 2
chondrocyte 1
Fgf1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 73 100.00 Very High Very High Very High
Dopamine 5 99.84 Very High Very High Very High
Substantia nigra 10 99.68 Very High Very High Very High
gABA 5 99.32 Very High Very High Very High
Ventral tegmentum 10 98.52 Very High Very High Very High
ischemia 190 97.84 Very High Very High Very High
Bile 144 95.92 Very High Very High Very High
Morphine 6 95.64 Very High Very High Very High
Osteoarthritis 46 93.64 High High
addiction 3 93.28 High High
Disease Link Frequency Relevance Heat
Myocardial Infarction 7 100.00 Very High Very High Very High
Cancer 630 99.62 Very High Very High Very High
Pancreatic Cancer 72 99.60 Very High Very High Very High
Diabetes Mellitus 32 98.80 Very High Very High Very High
Fibrosis 192 98.72 Very High Very High Very High
Disease 152 98.64 Very High Very High Very High
Stress 69 98.52 Very High Very High Very High
Cv General 4 Under Development 14 97.84 Very High Very High Very High
Cv Unclassified Under Development 178 96.56 Very High Very High Very High
Targeted Disruption 358 96.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have also identified a potentially important mutation in the growth factor gene Fgf1 in S10 that results in a nonsense codon in the predicted amino-acid sequence, and western analysis confirmed that normal FGF1 protein is not detectable in the brains of these animals.
Neg (not) Gene_expression (detectable) of FGF1 in brains
1) Confidence 0.74 Published 2005 Journal Genome Biol Section Body Doc Link PMC1175968 Disease Relevance 0.87 Pain Relevance 0.08
The prototypic Fgfs, Fgf1 (acidic Fgf) and Fgf2 (basic Fgf), which were originally isolated as mitogens for fibroblasts from the brain and pituitary, are widely expressed in developing and adult tissues.
Gene_expression (expressed) of Fgf in pituitary
2) Confidence 0.68 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.24 Pain Relevance 0
Fgf1 is mutated in S10 mice
Gene_expression (mutated) of Fgf1
3) Confidence 0.64 Published 2005 Journal Genome Biol Section Body Doc Link PMC1175968 Disease Relevance 0.13 Pain Relevance 0.10
The prototypic Fgfs, Fgf1 (acidic Fgf) and Fgf2 (basic Fgf), which were originally isolated as mitogens for fibroblasts from the brain and pituitary, are widely expressed in developing and adult tissues.
Gene_expression (expressed) of Fgf in pituitary
4) Confidence 0.59 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.25 Pain Relevance 0
The prototypic Fgfs, Fgf1 (acidic Fgf) and Fgf2 (basic Fgf), which were originally isolated as mitogens for fibroblasts from the brain and pituitary, are widely expressed in developing and adult tissues.
Gene_expression (expressed) of Fgf1 in pituitary
5) Confidence 0.59 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.25 Pain Relevance 0
Identification of hormone-like Fgf genes
Gene_expression (genes) of Fgf
6) Confidence 0.59 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.18 Pain Relevance 0.03
Evolutionary history of hormone-like Fgf genes in vertebrates
Gene_expression (genes) of Fgf
7) Confidence 0.59 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 1.30 Pain Relevance 0.08
Regulatory mechanism of hormone-like Fgf gene expression
Gene_expression (expression) of Fgf gene
8) Confidence 0.52 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.36 Pain Relevance 0.15
Expression of both vascular endothelial growth factor (VEGF) and FGF-1 was suppressed.
Gene_expression (Expression) of FGF-1
9) Confidence 0.43 Published 2005 Journal Biomed. Pharmacother. Section Abstract Doc Link 16507395 Disease Relevance 0.61 Pain Relevance 0.30
The responsible ligands are most likely FGF1, FGF7, FGF10, and FGF22, which are expressed in different compartments of the skin (Steiling and Werner, 2003).
Gene_expression (expressed) of FGF1 in skin
10) Confidence 0.43 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.22 Pain Relevance 0.04
In conclusion, we have identified a subset of genes with increased expression in noninfarcted left ventricular tissue following MI, including syndecans 1-4, WT-1, fibronectin, collagen 6A, and FGF receptor 1.
Gene_expression (expression) of FGF associated with myocardial infarction
11) Confidence 0.41 Published 2004 Journal Physiol. Genomics Section Abstract Doc Link 14625378 Disease Relevance 0.53 Pain Relevance 0.07
A study using a similar model demonstrated not only improved perfusion subsequent to bone marrow administration but also enhanced production of the angiogenic cytokines IL-1 and FGF-2 [31].
Gene_expression (production) of FGF in bone marrow associated with cytokine
12) Confidence 0.36 Published 2008 Journal J Transl Med Section Body Doc Link PMC2533293 Disease Relevance 0.66 Pain Relevance 0.18
Another approach involved use of the cytokine fibroblast growth factor-1 (FGF-1).
Gene_expression (use) of FGF in fibroblast associated with cytokine
13) Confidence 0.31 Published 2008 Journal J Transl Med Section Body Doc Link PMC2533293 Disease Relevance 0.42 Pain Relevance 0.16
The fibrotic tissue also contained nitrosylated proteins concordant with elevated numbers of chymase and FGF producing mast cells, indicative of oxidative stress and increased fibroproliferative factors driving cell survival and proliferation.
Gene_expression (producing) of FGF in mast cells associated with stress and fibrosis
14) Confidence 0.29 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940819 Disease Relevance 1.13 Pain Relevance 0.06
Another approach involved use of the cytokine fibroblast growth factor-1 (FGF-1).
Gene_expression (use) of cytokine fibroblast growth factor-1 in fibroblast associated with cytokine
15) Confidence 0.27 Published 2008 Journal J Transl Med Section Body Doc Link PMC2533293 Disease Relevance 0.42 Pain Relevance 0.16
The prototypic Fgfs, Fgf1 (acidic Fgf) and Fgf2 (basic Fgf), which were originally isolated as mitogens for fibroblasts from the brain and pituitary, are widely expressed in developing and adult tissues.
Gene_expression (expressed) of Fgf in brain
16) Confidence 0.23 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.24 Pain Relevance 0
The chymase-positive mast cells also expressed FGF (Figure 4F), a factor involved in mediating fibroblast proliferation and chondrocyte differentiation [36,37].
Gene_expression (expressed) of FGF in chondrocyte
17) Confidence 0.23 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940819 Disease Relevance 0.88 Pain Relevance 0.21
Within the fibrotic regions, elevated numbers of chymase/fibroblast growth factor (FGF)-expressing mast cells were observed.
Gene_expression (expressing) of FGF in fibroblast associated with fibrosis
18) Confidence 0.23 Published 2010 Journal Fibrogenesis Tissue Repair Section Abstract Doc Link PMC2940819 Disease Relevance 1.06 Pain Relevance 0
Within the fibrotic regions, elevated numbers of chymase/fibroblast growth factor (FGF)-expressing mast cells were observed.
Gene_expression (-) of FGF in fibroblast associated with fibrosis
19) Confidence 0.23 Published 2010 Journal Fibrogenesis Tissue Repair Section Abstract Doc Link PMC2940819 Disease Relevance 1.06 Pain Relevance 0
Here we show that the fibroblast growth factor-1 (FGF-1), that is expressed on dopamine and GABA neurons of the ventral tegmental area (VTA), is involved in the sensitizing effects of morphine.
Gene_expression (expressed) of fibroblast growth factor-1 in ventral associated with ventral tegmentum, gaba, dopamine and morphine
20) Confidence 0.21 Published 2010 Journal Neuroscience Section Abstract Doc Link 19819303 Disease Relevance 0.09 Pain Relevance 0.84

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