INT114714

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Context Info
Confidence 0.36
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 5.26
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGF1R) plasma membrane (IGF1R)
Anatomy Link Frequency
hepatocyte 1
pancreatic ducts 1
T cells 1
IGF1R (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 2 99.88 Very High Very High Very High
cva 1 99.78 Very High Very High Very High
rheumatoid arthritis 1 97.74 Very High Very High Very High
Potency 3 96.68 Very High Very High Very High
tolerance 3 92.20 High High
Multiple sclerosis 65 88.28 High High
chemokine 10 83.80 Quite High
Central nervous system 8 82.80 Quite High
Onset of action 4 72.40 Quite High
Inflammation 11 66.36 Quite High
Disease Link Frequency Relevance Heat
Pancreatitis 2 99.88 Very High Very High Very High
Cv General 3 Under Development 1 99.78 Very High Very High Very High
Adhesions 5 99.52 Very High Very High Very High
Pancreatic Cancer 4 99.24 Very High Very High Very High
Rheumatoid Arthritis 2 97.82 Very High Very High Very High
Cancer 184 97.12 Very High Very High Very High
Erythema 1 96.84 Very High Very High Very High
Fever 2 96.44 Very High Very High Very High
Adenocarcinoma 13 96.04 Very High Very High Very High
Prostate Cancer 53 90.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Preventive measures for thromboembolism had to be associated with IGF-IR/AS ODN administration [48].
IGF-IR Binding (associated) of associated with cva
1) Confidence 0.36 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2952949 Disease Relevance 0.98 Pain Relevance 0.10
To further study the interaction between c-Src and IGF-1R proteins in human pancreatic cancer, we examined their coexpression in 47 human pancreatic ductal adenocarcinomas (PDA).
IGF-1R Spec (examined) Binding (interaction) of associated with adenocarcinoma and pancreatic cancer
2) Confidence 0.30 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 14627343 Disease Relevance 0.60 Pain Relevance 0
Normal pancreatic ducts as well as areas of chronic pancreatitis were negative for IGF-1R.
IGF-1R Binding (negative) of in pancreatic ducts associated with chronic pancreatitis
3) Confidence 0.29 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 14627343 Disease Relevance 0.81 Pain Relevance 0.10
It can be activated upon engagement of growth factor receptors, such as EGFR, PDGFR, INSR or IGF1R, and in turn activate downstream PLC and PI3K signaling pathways [51], [52], [66].
IGF1R Binding (engagement) of
4) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 1.37 Pain Relevance 0
In vitro studies have demonstrated that the mitogenic potency of insulin analogs mostly correlates with their relative IGF-I receptor binding affinities and/or their rate of dissociation from the insulin receptor; analogs with high affinity for the IGF-I receptor and/or a low dissociation rate from the insulin receptor have increased mitogenic potency.
IGF-I receptor Binding (affinity) of associated with potency
5) Confidence 0.18 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770411 Disease Relevance 0.06 Pain Relevance 0.14
However, IGFR activation was not examined in this study and multiple pathways associated with IGFR and matrix adhesion signaling (i.e. integrin signaling) are likely acting in concert to produce the profound improvements seen after IGF-I treatment.
IGFR Binding (associated) of associated with adhesions
6) Confidence 0.13 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1851714 Disease Relevance 0.28 Pain Relevance 0
On the other hand, insulin molecule modifications in the B10 and B26-B30 region alter the affinity towards the IGF-1 receptor.
IGF-1 receptor Binding (affinity) of
7) Confidence 0.11 Published 2010 Journal Experimental Diabetes Research Section Body Doc Link PMC2877202 Disease Relevance 0 Pain Relevance 0.10
In rheumatoid arthritis (RA) it has been shown that IgG antibodies from the sera of patients can stimulate synovial fibroblasts through interaction with insulin-like growth factor receptor 1 (IGF-R1), provoking trafficking of T cells [31].
IGF-R1 Binding (interaction) of in T cells associated with rheumatoid arthritis
8) Confidence 0.03 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2227948 Disease Relevance 0.83 Pain Relevance 0.35
Cancer cells expressing EGFR and ErbB2 are nonresponsive to inhibitors targeting one of these two proteins.63 Similarly, overexpression of ErbB3 also confers resistance to EGFR inhibitors.64 Expression of hepatocyte growth factor and c-Met dependent signaling is also an alternative pathway for signaling conferring resistance (seen in approximately 20% of patients with acquired resistance to TKIs).65 Finally, interactions between EGFR and the insulin growth factor receptor (IGF-1R) can provide resistance to agents targeting EGFR.66
IGF-1R Binding (interactions) of in hepatocyte associated with cancer
9) Confidence 0.01 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886327 Disease Relevance 0.33 Pain Relevance 0

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