INT114740

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Context Info
Confidence 0.36
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.24
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (GRB2) endosome (GRB2) anatomical structure formation involved in morphogenesis (GRB2)
aging (GRB2) Golgi apparatus (GRB2) protein complex (GRB2)
GRB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
dopamine receptor 2 98.22 Very High Very High Very High
Serotonin 2 97.40 Very High Very High Very High
GABA receptor 2 96.98 Very High Very High Very High
Glutamate receptor 6 96.48 Very High Very High Very High
Neurotransmitter 4 95.90 Very High Very High Very High
antagonist 1 66.40 Quite High
Kinase C 5 56.56 Quite High
qutenza 3 25.00 Low Low
Antihistamine 4 5.00 Very Low Very Low Very Low
Dopamine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 29 96.56 Very High Very High Very High
Necrosis 5 95.04 Very High Very High Very High
Toxicity 22 86.12 High High
Adenocarcinoma 4 85.52 High High
Schizophrenia 100 84.56 Quite High
Stress 11 82.72 Quite High
Stomach Cancer 14 76.40 Quite High
Infection 27 60.40 Quite High
Disease 68 50.00 Quite Low
Sprains And Strains 37 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Exposure of environmental PMs containing residual oil fly ash and ash from Mount St.
ash Binding (containing) of
1) Confidence 0.36 Published 2004 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 14633515 Disease Relevance 0.80 Pain Relevance 0
Exposure of environmental PMs containing residual oil fly ash and ash from Mount St.
ash Binding (containing) of
2) Confidence 0.36 Published 2004 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 14633515 Disease Relevance 0.80 Pain Relevance 0
Among the four well-known neurotransmitter pathways (glutamate receptor signaling, GABA receptor signaling, serotonin receptor signaling and dopamine receptor signaling), GRB2 appeared in all the four pathways and HSPA5 in three pathways, and the interaction between GRB2 and HSPA5 appeared in three pathways.
GRB2 Spec (appeared) Binding (interaction) of associated with neurotransmitter, dopamine receptor, gaba receptor, glutamate receptor and serotonin
3) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894047 Disease Relevance 0.28 Pain Relevance 0.31
As a result, adapter proteins such as Grb2, Ras-specific GTPase-activating protein (GAP), and phosphatidylinositol-3-kinase (PI-3K), can interact with the phosphotyrosine residues and stimulate downstream signaling, including the Ras-MAPK and PI-3K-Akt pathways.
Grb2 Binding (interact) of
4) Confidence 0.28 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721306 Disease Relevance 0 Pain Relevance 0.03
Insulin receptor substrate protein 1 is phosphorylated by the insulin receptor and is then able to bind GRB2, which then activates the mitogen-activated protein kinase pathway through its interaction with SOS.
GRB2 Binding (bind) of
5) Confidence 0.24 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2528026 Disease Relevance 0 Pain Relevance 0.03
Recent study clearly confirmed that almost one dozen of factors such as SHP-1, Grd2, Grb2, phosphatidylinositol 3-OH kinase (PI3K), have also binding abilities to CagA phosphorylation sites [34].
Grb2 Binding (binding) of
6) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2768901 Disease Relevance 0.22 Pain Relevance 0
The adaptor protein Grb2 binds to the Y1356 docking site of c-Met [23].
Grb2 Binding (binds) of
7) Confidence 0.05 Published 2008 Journal BMC Syst Biol Section Body Doc Link PMC2254585 Disease Relevance 0.06 Pain Relevance 0
However, Akt inhibition may take place in a SIRT1 –independent way [35], [36] through disruption of interaction between upstream signaling elements such as PI3 Kinase or Grb2 (growth factor receptor-bound protein 2) with further upstream proteins relaying signals directly from the receptor [36].
factor receptor-bound protein 2 Binding (interaction) of
8) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0.08 Pain Relevance 0

General Comments

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