INT114741

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Context Info
Confidence 0.36
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 5.44
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PRB1) molecular_function (PRB1) biological_process (PRB1)
Anatomy Link Frequency
epithelium 1
heart 1
body 1
PRB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 45 100.00 Very High Very High Very High
tricyclic antidepressant 3 94.96 High High
Angina 49 93.60 High High
agonist 18 81.56 Quite High
Inflammation 15 73.76 Quite High
Duloxetine 1 72.48 Quite High
Codeine 1 55.28 Quite High
Inflammatory response 2 42.32 Quite Low
cytokine 16 29.48 Quite Low
qutenza 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Premenstrual Syndrome 139 100.00 Very High Very High Very High
Obesity 6 100.00 Very High Very High Very High
Adverse Drug Reaction 5 99.80 Very High Very High Very High
Bradycardia 9 99.76 Very High Very High Very High
Disease 122 98.52 Very High Very High Very High
Stress 22 95.28 Very High Very High Very High
Influenza Virus Infection 80 95.16 Very High Very High Very High
Apoptosis 8 93.84 High High
Angina 38 93.60 High High
Necrosis 2 90.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Levels of evidence for the association between CYP2D6 PMs and ADRs are relatively reasonable and include systematic reviews of case-control studies of some typical antipsychotics and tricyclic antidepressants (TCAs).
PMs Binding (association) of associated with adverse drug reaction and tricyclic antidepressant
1) Confidence 0.36 Published 2006 Journal Molecular diagnosis & therapy Section Abstract Doc Link 16771600 Disease Relevance 0.38 Pain Relevance 0.19
Although PMS is widely recognized, its etiopathogenesis is not yet understood.
PMS Binding (recognized) of associated with dismenorea
2) Confidence 0.31 Published 2007 Journal Biopsychosoc Med Section Abstract Doc Link PMC2253548 Disease Relevance 0.45 Pain Relevance 0.36
The cells that respond to PRF and PMF appear to be evenly distributed in the vomeronasal epithelium.
PMF Binding (respond) of in epithelium
3) Confidence 0.14 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1550415 Disease Relevance 0 Pain Relevance 0
APA: American Psychiatric Association; BMI: body mass index; PMDD: premenstrual dysphoric disorder; PMS: premenstrual syndrome

Competing interests

PMS Binding (index) of in body associated with obesity, dismenorea and premenstrual syndrome
4) Confidence 0.06 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2992541 Disease Relevance 0.94 Pain Relevance 0.20
Taking the NZ–OH distance as the reaction coordinate, the PMF for the Lys145 and Tyr188 interaction was calculated using an umbrella sampling method [53].
PMF Binding (interaction) of
5) Confidence 0.06 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1584325 Disease Relevance 0 Pain Relevance 0.04
Binding of either one of the PMs to the cell membrane induced a capsazepine-sensitive increase in cAMP.
PMs Binding (Binding) of
6) Confidence 0.05 Published 2004 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 14633515 Disease Relevance 0.91 Pain Relevance 0
Contrast the silent AND gate with the system in Fig. 4C, where elements n4 and
                       n5 implement the operation NOISY COPY, i.e. have
                   the same mechanism as an AND gate in which one input connection
                   is given extrinsic noise. 
NOISY COPY Binding (implement) of
7) Confidence 0.03 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2713405 Disease Relevance 0 Pain Relevance 0
This study indicates that the EPFRs associated with PM may be a key factor in the health effects of the latter.
PM Binding (associated) of
8) Confidence 0.03 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2676242 Disease Relevance 0.28 Pain Relevance 0.04
The study found that temperature modified the association between PM10 and mortality, but the results were sensitive to the number of degrees of freedom.
PM10 Binding (association) of
9) Confidence 0.02 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665419 Disease Relevance 0.12 Pain Relevance 0
A range of studies have shown that PM10 is consistently associated with health outcomes (Dominici et al. 2006; Samet et al. 2000).
PM10 Binding (associated) of
10) Confidence 0.02 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665419 Disease Relevance 0.28 Pain Relevance 0
No obvious J-shaped pattern was observed in the bivariate response surface models, suggesting that the interaction between PM10 and temperature may play an important role in model fit.
PM10 Binding (interaction) of
11) Confidence 0.02 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665419 Disease Relevance 0 Pain Relevance 0
Some studies have shown that PM10 is associated with decreased heart rate variation (Creason et al. 2001; Gold et al. 2000).
PM10 Binding (associated) of in heart associated with bradycardia
12) Confidence 0.02 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665419 Disease Relevance 0.35 Pain Relevance 0
Poisson generalized additive models (GAM) were employed to explore the associations of temperature and PM10 with health outcomes.
PM10 Binding (associations) of
13) Confidence 0.02 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665419 Disease Relevance 0.23 Pain Relevance 0
Therefore, both high ambient temperature and high ambient PM10 may interact to synergistically effect human morbidity/mortality.
PM10 Binding (interact) of
14) Confidence 0.02 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665419 Disease Relevance 0.35 Pain Relevance 0
Our recent study also found that temperature significantly modified the association between PM10 and health outcomes (Ren and Tong, in press).
PM10 Binding (association) of
15) Confidence 0.02 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665419 Disease Relevance 0.08 Pain Relevance 0
Then we used three GAM models to assess whether PM10 modified the association of temperature with health outcomes: a nonparametric bivariate response model, a nonstratification model, and a stratification model (Ren and Tong, in press; Roberts 2004).
PM10 Binding (association) of
16) Confidence 0.02 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665419 Disease Relevance 0.36 Pain Relevance 0
We modified Equation 1 to include a bivariate term for temperature and PM10 as follows (Insightful Corporation 2001; Ren and Tong, in press; Roberts 2004):
PM10 Binding (term) of
17) Confidence 0.02 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665419 Disease Relevance 0 Pain Relevance 0
The association of minimum PM10 with the outcome did not change over the outbreak period.
PM10 Binding (association) of
18) Confidence 0.01 Published 2007 Journal Environ Health Section Body Doc Link PMC2212623 Disease Relevance 0.25 Pain Relevance 0
Nevertheless, PM10 has been found to be associated with cardiovascular visits in Sydney, particularly in the cooler part of the year [4].
PM10 Binding (associated) of
19) Confidence 0.01 Published 2007 Journal Environ Health Section Body Doc Link PMC2212623 Disease Relevance 0.46 Pain Relevance 0.18

General Comments

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