INT114748

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Context Info
Confidence 0.16
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.08
Pain Relevance 1.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Syt17) molecular_function (Syt17) biological_process (Syt17)
Anatomy Link Frequency
DRG 1
Syt17 (Mus musculus)
Pain Link Frequency Relevance Heat
bradykinin 23 100.00 Very High Very High Very High
agonist 4 100.00 Very High Very High Very High
dorsal root ganglion 5 99.56 Very High Very High Very High
B1 receptor 4 95.56 Very High Very High Very High
Hyperalgesia 2 92.24 High High
gABA 2 89.56 High High
unmyelinated 2 89.56 High High
Action potential 4 82.24 Quite High
b2 receptor 3 78.68 Quite High
antagonist 2 75.16 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 1 99.60 Very High Very High Very High
Ganglion Cysts 5 99.56 Very High Very High Very High
Nociception 9 99.36 Very High Very High Very High
Hyperalgesia 2 92.24 High High
Ataxia 42 86.28 High High
Hypersensitivity 5 85.92 High High
Nervous System Injury 3 76.40 Quite High
Pain 1 63.88 Quite High
Congenital Anomalies 2 15.68 Low Low
Depression 2 7.52 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BK or B1 agonist-induced activation of ERK in DRG neurons of nerve-injured mice was completely blocked by pretreatment with antisense oligodeoxynucleotide (AS-ODN) for B1 receptor.
Positive_regulation (activation) of BK in DRG associated with dorsal root ganglion, b1 receptor, agonist and bradykinin
1) Confidence 0.16 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14634040 Disease Relevance 1.15 Pain Relevance 1.27
Notably, the Ca2+ influx stimulates BK channels, contributing to fast after-hyperpolarization [39].
Positive_regulation (stimulates) of BK
2) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776494 Disease Relevance 0.30 Pain Relevance 0.04
Maximal activation of BK channels (alias maxiK, KCNMA1, KCa1.1 or slowpoke) requires both membrane depolarization and increased intracellular Ca2+[4], [5].
Positive_regulation (activation) of BK
3) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776494 Disease Relevance 0.08 Pain Relevance 0
TRPA1 knockout mice show impaired responses to BK and mechanical nociception.
Positive_regulation (responses) of BK associated with nociception, targeted disruption and bradykinin
4) Confidence 0.04 Published 2009 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 19033534 Disease Relevance 0.55 Pain Relevance 0.47

General Comments

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