INT114751

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Context Info
Confidence 0.76
First Reported 2001
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 137
Total Number 143
Disease Relevance 60.14
Pain Relevance 39.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk1) mitochondrion (Mapk1) protein complex (Mapk1)
cytoplasm (Mapk1) cytosol (Mapk1) signal transduction (Mapk1)
Anatomy Link Frequency
spinal cord 5
macrophage 4
microglia 4
retinas 3
brain 3
Mapk1 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 93 100.00 Very High Very High Very High
bradykinin 20 99.88 Very High Very High Very High
Hyperalgesia 85 99.84 Very High Very High Very High
unmyelinated 34 99.84 Very High Very High Very High
qutenza 16 99.82 Very High Very High Very High
Pain 220 99.74 Very High Very High Very High
Spinal cord 561 99.68 Very High Very High Very High
amygdala 86 99.68 Very High Very High Very High
opioid receptor 134 99.64 Very High Very High Very High
agonist 324 99.46 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 1497 100.00 Very High Very High Very High
Apoptosis 487 100.00 Very High Very High Very High
Stress 315 100.00 Very High Very High Very High
Nociception 119 100.00 Very High Very High Very High
Depression 102 100.00 Very High Very High Very High
Nervous System Injury 141 99.98 Very High Very High Very High
Hyperalgesia 151 99.84 Very High Very High Very High
Congenital Anomalies 64 99.84 Very High Very High Very High
Myeloid Leukemia 11 99.84 Very High Very High Very High
Urological Neuroanatomy 20 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two ERK isoforms, ERK1 and ERK2, are expressed in virtually every cell types.
Gene_expression (expressed) of ERK
1) Confidence 0.76 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1420315 Disease Relevance 0 Pain Relevance 0.26
Two ERK isoforms, ERK1 and ERK2, are expressed in virtually every cell types.
Gene_expression (expressed) of ERK2
2) Confidence 0.76 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1420315 Disease Relevance 0 Pain Relevance 0.26
ERK is expressed in neuronal as well as non-neuronal cells [11] and the above mentioned studies have shown that ERK activation occurs in both neuronal and glial cells of the spinal cord.
Gene_expression (expressed) of ERK in neuronal associated with spinal cord
3) Confidence 0.74 Published 2006 Journal Mol Pain Section Body Doc Link PMC1382249 Disease Relevance 0.44 Pain Relevance 0.65
We show here that ERK phosphorylation, following MDMA injection, occurs exclusively in DARPP32-expressing neurons, whereas no ERK labeling was detected in D2 receptor (EGFP)-expressing neurons.
Neg (no) Gene_expression (detected) of ERK in neurons
4) Confidence 0.71 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775951 Disease Relevance 0.22 Pain Relevance 0.34
Role of the ERK pathway in the development of locomotor sensitization induced by cocaine
Gene_expression (pathway) of ERK associated with cocaine
5) Confidence 0.66 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1420315 Disease Relevance 0 Pain Relevance 0.28
However, anti-NGF treatment did not reduce p-ERK and c-Fos expression at 20 and 90 min, respectively, following fracture.
Gene_expression (expression) of ERK
6) Confidence 0.65 Published 2007 Journal Pain Section Abstract Doc Link 17693023 Disease Relevance 0.93 Pain Relevance 0.94
Furthermore, ERK activation in the amygdala was shown to be not only necessary for inflammation-induced peripheral hypersensitivity but also sufficient to induce peripheral tactile hypersensitivity in the absence of tissue injury.
Gene_expression (activation) of ERK in amygdala associated with inflammation, injury, hypersensitivity and amygdala
7) Confidence 0.64 Published 2008 Journal Mol Pain Section Body Doc Link PMC2443116 Disease Relevance 1.29 Pain Relevance 1.00
In the current studies, we do not observe suppressed basal ERK activation in the spinal cords of the DN MEK mice.
Gene_expression (activation) of ERK in spinal cords
8) Confidence 0.64 Published 2006 Journal Mol Pain Section Body Doc Link PMC1382249 Disease Relevance 0.40 Pain Relevance 0.27
When we examined the activation of extracellular signal-regulated protein kinase (ERK) in dorsal root ganglion (DRG) neurons upon i.pl. injection of BK, phosphorylated ERK was mainly observed in unmyelinated neurons in sham-operated mice, and in case of nerve-injured mice, ERK was mainly activated in myelinated neurons and satellite cells.
Gene_expression (observed) of ERK in DRG associated with ganglion cysts, dorsal root ganglion, unmyelinated and bradykinin
9) Confidence 0.63 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14634040 Disease Relevance 1.01 Pain Relevance 1.19
Thus, in at least two different cell lines, HEK-293 and C6 glioma, we have significant evidence that transactivation of an endogenously expressed RTK is not required for ERK activation through opioid receptors.
Gene_expression (activation) of ERK associated with opioid receptor and glioma
10) Confidence 0.61 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0.29 Pain Relevance 0.26
C6 glioma cells have been used as host cells for the transfection of several GPCR types, and have the advantage of expressing high levels of ERK, while being devoid of the EGFR.
Gene_expression (expressing) of ERK associated with glioma
11) Confidence 0.61 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0.19 Pain Relevance 0.19
It is possible that these sites can be used as surrogate scaffold proteins during ERK activation, and we explored the possibility that ?
Gene_expression (activation) of ERK
12) Confidence 0.61 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0.21 Pain Relevance 0.33
While the EGFR does not appear to be phosphorylated during DSLET-mediated ERK activation, it is possible that the EGFR is somehow involved in this response when it is present.
Gene_expression (activation) of ERK
13) Confidence 0.61 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0.23 Pain Relevance 0.24
PTX did not attenuate EGF-mediated ERK activation (Figure 2a), although this response was completely blocked by the EGFR kinase inhibitor, AG1478 (1 ?
Gene_expression (activation) of ERK
14) Confidence 0.61 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0 Pain Relevance 0.23
Functionally, these cells are no longer capable of activating ERK 1 or 2 in response to 10 ng/ml EGF (Figure), whereas this concentration produces a strong effect in non-pretreated cells.
Gene_expression (activating) of ERK
15) Confidence 0.61 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0.05 Pain Relevance 0.12
HEK-293 cells endogenously express the EGFR, and EGF produces robust ERK activation concomitant with EGFR tyrosine phosphorylation.
Gene_expression (produces) of ERK
16) Confidence 0.61 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0.15 Pain Relevance 0.13
Moreover, no change in total ERK expression was observed, concomitantly, with ERK phosphorylation in any of our experiments (data not shown).
Gene_expression (expression) of ERK
17) Confidence 0.61 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0 Pain Relevance 0.24
DSLET-mediated ERK activation was significantly inhibited by the Src kinase inhibitor, PP1 (10 ?
Gene_expression (activation) of ERK
18) Confidence 0.61 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0 Pain Relevance 0.16
In this report, we questioned whether the EGFR acts as a surrogate scaffold during ERK activation through the ?
Gene_expression (activation) of ERK
19) Confidence 0.61 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0 Pain Relevance 0.07
We studied the appearance of phospho-ERK immunoreactive neurons in CD-1 mouse brain following acute administration of drugs commonly abused by humans, cocaine, morphine, nicotine and THC, or of other psychoactive compounds including caffeine, scopolamine, antidepressants and antipsychotics.
Gene_expression (appearance) of ERK in brain associated with antidepressant, nicotine, delta-9-tetrahydrocannabinol, morphine and cocaine
20) Confidence 0.60 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15078556 Disease Relevance 0 Pain Relevance 0.55

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