INT114753

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Context Info
Confidence 0.42
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 4.79
Pain Relevance 2.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crp) extracellular region (Crp)
Anatomy Link Frequency
coronary artery 2
plasma 2
Crp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 11 100.00 Very High Very High Very High
Pain 7 99.38 Very High Very High Very High
Angina 4 97.56 Very High Very High Very High
Infliximab 4 95.36 Very High Very High Very High
aspirin 54 94.92 High High
Analgesic 2 94.24 High High
methotrexate 4 94.16 High High
antagonist 3 94.00 High High
Perioperative pain 1 93.68 High High
Snapping jaw 8 92.48 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 14 100.00 Very High Very High Very High
Coronary Artery Disease 5 100.00 Very High Very High Very High
Arthralgia 2 99.38 Very High Very High Very High
Diabetes Mellitus 114 98.80 Very High Very High Very High
Hypertension 9 96.56 Very High Very High Very High
Cardiovascular Disease 30 96.26 Very High Very High Very High
Post Operative Pain 1 93.68 High High
Pain 5 88.44 High High
Temporomandibular Joint Syndrome 8 88.24 High High
Dyslipidemia /

Combined Dyslipidemia

5 79.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Levels of high-sensitivity C-reactive protein decreased after treatment with antispastic agents.
Negative_regulation (decreased) of Gene_expression (Levels) of C-reactive protein
1) Confidence 0.42 Published 2005 Journal Am. J. Cardiol. Section Abstract Doc Link 15619396 Disease Relevance 0.15 Pain Relevance 0.26
The Cox proportional hazards model adjusting for coronary risk factors, ACS presentation, extent of coronary artery disease, C-reactive protein and other covariates identified leucocyte count with a HR (hazard ratio)=1.05 (95% CI 1.02-1.07; P<0.001 for 1000 cells/mm(3) increase in the leucocyte count), but not C-reactive protein (HR=1.13, 95% CI 0.95-1.34; P=0.15 for a 1 tertile increase in the C-reactive protein concentration) as an independent correlate of 1-year mortality.
Negative_regulation (presentation) of Gene_expression (adjusting) of C-reactive protein in coronary artery associated with coronary artery disease
2) Confidence 0.37 Published 2009 Journal Clin. Sci. Section Abstract Doc Link 18851714 Disease Relevance 0.38 Pain Relevance 0.08
In addition, preoperative administration of ibuprofen has proved to reduce interleukin-6 (IL-6) release, while that of ranitidine reduced postoperative IL-6-induced C-reactive protein synthesis in patients undergoing abdominal surgery.
Negative_regulation (reduced) of Gene_expression (synthesis) of C-reactive protein
3) Confidence 0.11 Published 2004 Journal Eur Spine J Section Abstract Doc Link 14634855 Disease Relevance 0.42 Pain Relevance 0.36
Several studies have shown that treatment with statins is associated with a decrease in the levels of C-reactive protein in just a few weeks [20,21].
Negative_regulation (decrease) of Gene_expression (levels) of C-reactive protein
4) Confidence 0.04 Published 2007 Journal Trials Section Body Doc Link PMC2014771 Disease Relevance 0.69 Pain Relevance 0.42
On the vascular side, high levels of UA are linked to cardiovascular diseases, especially HT.82–86 If patients are already at risk, then UA represents a serious problem.87,88 Mechanisms that are responsible for the deleterious UA effects are linked to increased C reactive protein, inflammation and reduced NO production, thereby hampering vascular reactivity.38,82,84,89
Neg (NO) Negative_regulation (reduced) of Neg (NO) Gene_expression (production) of reactive protein associated with inflammation, cardiovascular disease and hypertension
5) Confidence 0.03 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2910863 Disease Relevance 0.99 Pain Relevance 0.05
Reduced general joint pain intensity was associated with reduced plasma levels of IL-6 and C-reactive protein.
Negative_regulation (reduced) of Gene_expression (levels) of C-reactive protein in plasma associated with pain and arthralgia
6) Confidence 0.02 Published 2005 Journal Cells Tissues Organs (Print) Section Abstract Doc Link 16088130 Disease Relevance 1.05 Pain Relevance 1.62
Furthermore, data from our laboratory suggests that low cardiorespiratory fitness is associated with a decline in arterial compliance and significantly elevated C-reactive protein expression in postmenopausal women with DM-2 [11].
Negative_regulation (decline) of Gene_expression (expression) of C-reactive protein associated with diabetes mellitus
7) Confidence 0.01 Published 2004 Journal Cardiovasc Diabetol Section Body Doc Link PMC400749 Disease Relevance 0.98 Pain Relevance 0

General Comments

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