INT114761

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Context Info
Confidence 0.71
First Reported 2003
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 0.93
Pain Relevance 0.83

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signal transduction (Tas1r2) plasma membrane (Tas1r2) signal transducer activity (Tas1r2)
Anatomy Link Frequency
taste bud 3
taste receptor cells 1
Tas1r2 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 3 99.92 Very High Very High Very High
Opioid 1 98.68 Very High Very High Very High
opiate 4 97.68 Very High Very High Very High
Glutamate 15 87.08 High High
Glutamate receptor 2 51.48 Quite High
Calcium channel 6 49.04 Quite Low
medulla 44 5.00 Very Low Very Low Very Low
trigeminal ganglion 18 5.00 Very Low Very Low Very Low
parabrachial 9 5.00 Very Low Very Low Very Low
fifth nerve 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 74 99.10 Very High Very High Very High
Appetite Loss 5 59.52 Quite High
Stress 2 13.52 Low Low
Ganglion Cysts 53 5.00 Very Low Very Low Very Low
Sprains And Strains 18 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Aggression 4 5.00 Very Low Very Low Very Low
Blister 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To examine the basis of sweet tastant recognition and coding, we engineered animals expressing either the human T1R2-receptor (hT1R2), or a modified opioid-receptor (RASSL) in sweet cells.
Gene_expression (expressing) of T1R2 associated with opioid
1) Confidence 0.71 Published 2003 Journal Cell Section Abstract Doc Link 14636554 Disease Relevance 0.09 Pain Relevance 0.22
The discovery that T1r1, T1r2 and T2rs do not co-express in the taste bud [8] suggests that subsets of cells expressing T1r1, T1r2, and T2rs may constitute the origin of a labeled line for umami, sweet and bitter, respectively.
Gene_expression (co-express) of T1r2 in taste bud
2) Confidence 0.58 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2571104 Disease Relevance 0.24 Pain Relevance 0.10
The discovery that T1r1, T1r2 and T2rs do not co-express in the taste bud [8] suggests that subsets of cells expressing T1r1, T1r2, and T2rs may constitute the origin of a labeled line for umami, sweet and bitter, respectively.
Gene_expression (expressing) of T1r2 in taste bud
3) Confidence 0.58 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2571104 Disease Relevance 0.26 Pain Relevance 0.11
2 knockout mice restores bitter but not sweet or umami tastes [9], and transgenic expression of a modified opioid receptor in T1r2-expressing taste receptor cells leads to preference for a synthetic opiate [10].
Gene_expression (expressing) of T1r2 in taste receptor cells associated with targeted disruption, opiate and opioid receptor
4) Confidence 0.58 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2571104 Disease Relevance 0.29 Pain Relevance 0.15
Expression studies have revealed that taste cells either coexpress T1R1 and T1R3 or T1R2 and T1R3, but not T1R1 and T1R2 [22,23], and it has recently been shown that these distinct combinations of T1Rs bind to different sets of compounds, corresponding to sweet and umami substances [23-25]: in mouse, T1R2-T1R3 hetero(di)mers respond to sugars and sweeteners, whereas T1R1-T1R3 hetero(di)mers are activated by many L-amino acids, including L-glutamate and L-arginine, both of which are umami-tasting to humans.
Neg (not) Gene_expression (coexpress) of T1R2 associated with glutamate
5) Confidence 0.21 Published 2003 Journal Genome Biol Section Body Doc Link PMC193622 Disease Relevance 0 Pain Relevance 0.13
Expression studies have revealed that taste cells either coexpress T1R1 and T1R3 or T1R2 and T1R3, but not T1R1 and T1R2 [22,23], and it has recently been shown that these distinct combinations of T1Rs bind to different sets of compounds, corresponding to sweet and umami substances [23-25]: in mouse, T1R2-T1R3 hetero(di)mers respond to sugars and sweeteners, whereas T1R1-T1R3 hetero(di)mers are activated by many L-amino acids, including L-glutamate and L-arginine, both of which are umami-tasting to humans.
Neg (not) Gene_expression (coexpress) of T1R2 associated with glutamate
6) Confidence 0.16 Published 2003 Journal Genome Biol Section Body Doc Link PMC193622 Disease Relevance 0 Pain Relevance 0.13
The demonstration of two non-overlapping sets of T1R and T2R expressing cells in mice suggests that sweet or bitter tastes might be encoded by activation of different subsets of taste receptor cells (TRCs) within the same taste bud [6].
Gene_expression (expressing) of T1R in taste bud
7) Confidence 0.02 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC153500 Disease Relevance 0 Pain Relevance 0
There is, however, some discrepancy between the pattern of T1R expression and physiological data in mice.
Gene_expression (expression) of T1R
8) Confidence 0.02 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC153500 Disease Relevance 0.06 Pain Relevance 0

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