INT114773

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Context Info
Confidence 0.43
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.55
Pain Relevance 2.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (GABBR1) plasma membrane (GABBR1) transcription factor binding (GABBR1)
cytoplasm (GABBR1) signal transducer activity (GABBR1)
Anatomy Link Frequency
brain 1
GABBR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 5 100.00 Very High Very High Very High
gABA 4 100.00 Very High Very High Very High
agonist 3 100.00 Very High Very High Very High
cocaine 20 99.96 Very High Very High Very High
Glutamate 4 99.76 Very High Very High Very High
addiction 4 99.48 Very High Very High Very High
alcohol 2 99.26 Very High Very High Very High
Neurotransmitter 2 98.56 Very High Very High Very High
Rostral ventrolateral medulla 1 97.64 Very High Very High Very High
Cannabinoid 1 97.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cough 5 100.00 Very High Very High Very High
Alcohol Addiction 1 99.48 Very High Very High Very High
Opiate Addiction 1 61.76 Quite High
Cocaine Dependence 2 25.00 Low Low
Nicotine Addiction 1 25.00 Low Low
Syndrome 4 5.00 Very Low Very Low Very Low
Convulsion 4 5.00 Very Low Very Low Very Low
Epilepsy 3 5.00 Very Low Very Low Very Low
Sleep Disorders 1 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Preclinical and clinical studies suggest that GABAB receptor agonists selectively decrease cocaine use.
Negative_regulation (decrease) of GABAB receptor associated with agonist and cocaine
1) Confidence 0.43 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16407903 Disease Relevance 0.06 Pain Relevance 0.67
Neurotransmitter studies have shown that in alcohol dependence, GABA(A)-benzodiazepine (GABA-BDZ) receptors are reduced in a number of brain regions and suggest that there may be 'capacity within the system' in some benzodiazepine functions, but tolerance to others, e.g., time asleep.
Negative_regulation (reduced) of GABA-BDZ in brain associated with addiction, gaba, neurotransmitter, tolerance and alcohol
2) Confidence 0.37 Published 2003 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 14636961 Disease Relevance 0.10 Pain Relevance 0.88
Specific receptor subtypes have been associated with the suppression of cough at central sites, including 5-HT1A, opioid (mu, kappa, and delta), GABA-B, tachykinin neurokinin-1 (NK-1) and neurokinin-2, non-opioid (NOP-1), cannabinoid, dopaminergic, and sigma receptors.
Negative_regulation (suppression) of GABA-B associated with gaba, cannabinoid, cough and opioid
3) Confidence 0.21 Published 2009 Journal Handb Exp Pharmacol Section Abstract Doc Link 18825342 Disease Relevance 0.39 Pain Relevance 0.58
In agreement with the finding that ISOs are resistant to ionotropic glutamate, GABAA and GABAB receptor blockers, the ISO-related long-lasting hyperpolarizing potentials were resistant to the combined application of the GABAA and GABAB receptor antagonists, SR95531 (10 µM) and CGP54626 (10 µM), respectively (n?
Negative_regulation (blockers) of GABAB receptor associated with glutamate and antagonist
4) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2637539 Disease Relevance 0 Pain Relevance 0.20

General Comments

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