INT1148

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Context Info
Confidence 0.48
First Reported 1975
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 38
Total Number 41
Disease Relevance 25.27
Pain Relevance 13.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain 3
ECs 3
capillary 3
macrophages 2
ECs 1
ecs (Mus musculus)
Pain Link Frequency Relevance Heat
Endocannabinoid 184 100.00 Very High Very High Very High
Hippocampus 15 99.98 Very High Very High Very High
Inflammation 263 99.84 Very High Very High Very High
reflex sympathetic dystrophy 6 99.84 Very High Very High Very High
ischemia 199 99.82 Very High Very High Very High
Neuropathic pain 6 99.58 Very High Very High Very High
Opioid 5 99.36 Very High Very High Very High
anesthesia 10 99.16 Very High Very High Very High
Enkephalin 26 98.88 Very High Very High Very High
Cannabinoid receptor 7 98.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Shock 99 100.00 Very High Very High Very High
Convulsion 36 100.00 Very High Very High Very High
Vasculitis 6 100.00 Very High Very High Very High
INFLAMMATION 278 99.84 Very High Very High Very High
Complex Regional Pain Syndromes 6 99.84 Very High Very High Very High
Cv Unclassified Under Development 199 99.82 Very High Very High Very High
Stress 116 99.82 Very High Very High Very High
Vomiting 240 99.80 Very High Very High Very High
Colon Cancer 43 99.68 Very High Very High Very High
Neuropathic Pain 12 99.58 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine decreased the intensity of maximal electroshock seizures (MES) and increased the threshold for ECS.
Positive_regulation (increased) of ECS associated with convulsion and morphine
1) Confidence 0.48 Published 2003 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 12667893 Disease Relevance 0.86 Pain Relevance 0.72
These results indicate that the peripheral ECS is activated in CRPS.
Positive_regulation (activated) of ECS associated with reflex sympathetic dystrophy
2) Confidence 0.45 Published 2009 Journal Eur Surg Res Section Abstract Doc Link 19729930 Disease Relevance 1.00 Pain Relevance 0.93
Interstitial concentrations of 5-HT increased several fold in response to ECS and this increase was accompanied by a significant increase in the concentration of HVA.
Positive_regulation (increased) of ECS associated with shock
3) Confidence 0.42 Published 1992 Journal Neuropsychopharmacology Section Abstract Doc Link 1382432 Disease Relevance 0.76 Pain Relevance 0.29
In the third experiment two groups of rats received daily ECS and sham-ECS, respectively.
Positive_regulation (received) of ECS
4) Confidence 0.41 Published 1993 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7870993 Disease Relevance 0.54 Pain Relevance 0.29
In the third experiment two groups of rats received daily ECS and sham-ECS, respectively.
Positive_regulation (received) of ECS
5) Confidence 0.41 Published 1993 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7870993 Disease Relevance 0.54 Pain Relevance 0.29
At day 3 and day 6 after ECS X VII the motor activity was increased in comparison to that in untreated control animals during the whole 1 hour period.
Positive_regulation (increased) of ECS X VII associated with shock
6) Confidence 0.41 Published 1975 Journal J. Neural Transm. Section Abstract Doc Link 164522 Disease Relevance 1.28 Pain Relevance 0.42
Rectal sensitivity was enhanced to a greater degree in D-IBS patients exhibiting an elevated level of rectal ECs.
Positive_regulation (elevated) of ECs in ECs
7) Confidence 0.39 Published 2006 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 16771769 Disease Relevance 0.42 Pain Relevance 0.26
RESULTS: The results demonstrated that the majority of senior staff (75%) believed that ECS were effective in preventing PTS and in managing venous symptoms.
Positive_regulation (effective) of ECS
8) Confidence 0.36 Published 2010 Journal Phlebology Section Body Doc Link 20348453 Disease Relevance 0.18 Pain Relevance 0
One single active escape trial preceding ECS prevented ECS-interference with the subsequent acquisition of the task.
Positive_regulation (preceding) of ECS associated with shock
9) Confidence 0.36 Published 1986 Journal Physiol. Behav. Section Abstract Doc Link 3823168 Disease Relevance 0.89 Pain Relevance 0.16
We further suggest that the acute action of ECS may be mediated by substances with only partial opiate characteristics, while the long term effects observed may be due to the increase in brain enkephalin contents after chronic ECS application.
Spec (may) Positive_regulation (mediated) of ECS in brain associated with shock, enkephalin and opiate
10) Confidence 0.35 Published 1983 Journal Brain Res. Section Abstract Doc Link 6299458 Disease Relevance 1.07 Pain Relevance 1.33
HR was found to increase by 25% and 8% in the ECS and MST conditions, respectively.
Positive_regulation (increase) of ECS
11) Confidence 0.33 Published 2009 Journal Neuroimage Section Abstract Doc Link 19497373 Disease Relevance 0.44 Pain Relevance 0.07
Although the exact ECS-dependent mechanisms underlying migraine are not fully understood, the available results strongly suggest that activation of ECS could represent a promising therapeutical tool for reducing both the physiological and inflammatory components of pain that are likely involved in migraine attacks.
Positive_regulation (activation) of ECS associated with pain, inflammation and migraine
12) Confidence 0.31 Published 2010 Journal Exp. Neurol. Section Abstract Doc Link 20353780 Disease Relevance 0.92 Pain Relevance 1.02
Thus, it is possible that the amnestic effect of ECS is mediated by an endogenous release of the peptides.
Spec (possible) Positive_regulation (mediated) of ECS associated with shock
13) Confidence 0.30 Published 1984 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 6529615 Disease Relevance 1.12 Pain Relevance 0.66
Disability score varied for ECS x NT and Cirkan x NT. chi2 test detected different distribution frequency for C3 and C2 classes according to treatment: ECS (both limbs) and Cirkan (only left limb).
Positive_regulation (varied) of ECS in limb
14) Confidence 0.27 Published 2009 Journal Int Angiol Section Body Doc Link 19506542 Disease Relevance 0.07 Pain Relevance 0
When the seizure induced by ECS was prevented by pretreatment with an anesthetic dose of phenobarbital, the ECS-induced increase in hypothalamic and septal ME content was also blocked. beta-Endorphin content of hypothalamus remained unchanged after repeated ECS despite a two-fold increase in the ME content in the same region.
Positive_regulation (increase) of ECS in hypothalamus associated with convulsion, shock and enkephalin
15) Confidence 0.13 Published 1979 Journal Brain Res. Section Abstract Doc Link 497832 Disease Relevance 1.12 Pain Relevance 0.87
N intraventricular injections (30 micrograms/kg) increased the amplitude of NP20-40 EP to ETS, but not to ECS.
Neg (not) Positive_regulation (increased) of ECS in ETS
16) Confidence 0.08 Published 1988 Journal Physiol Bohemoslov Section Abstract Doc Link 2975796 Disease Relevance 0.07 Pain Relevance 0.21
In these model conditions, activated 12/15LO regulates monocyte attachment to ECs in part by increasing expression of adhesion molecule ICAM-1 on the surface of ECs via activation of RhoA and NF-?
Positive_regulation (surface) of ECs in ECs associated with adhesions
17) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2746280 Disease Relevance 1.75 Pain Relevance 0.21
The content of leu-enkephalin-like immunoreactive substance (LEK-LIS) in perfusate from the hippocampus increased after repeated electroconvulsive shock (ECS), while the content of LEK-LIS was not changed after single ECS.
Positive_regulation (increased) of ECS in LEK associated with shock, hippocampus and enkephalin
18) Confidence 0.07 Published 1989 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 2558496 Disease Relevance 0.53 Pain Relevance 0.71
Moreover, we found that IQGAP1 expression is dramatically increased in the regenerating ECs layers after vascular injury [18] as well as in capillary-like ECs during angiogenesis after hindlimb ischemia [21].
Positive_regulation (increased) of ECs in capillary associated with ischemia and vasculitis
19) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955540 Disease Relevance 0.38 Pain Relevance 0.07
Blood cells themselves are, however, a significant source of endocannabinoids [18] and this, together with the CB1-receptor expression measured on these cells indicates differences in stress-induced activation of the ECS in blood cells between individuals with and without motion sickness.
Positive_regulation (activation) of ECS in blood cells associated with stress, endocannabinoid and vomiting
20) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873996 Disease Relevance 0.81 Pain Relevance 0.30

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