INT11480

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Context Info
Confidence 0.30
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 6.39
Pain Relevance 5.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (KNG1) extracellular region (KNG1) plasma membrane (KNG1)
Anatomy Link Frequency
plasma 4
neuronal 2
endothelial cells 2
nerve 2
capillary 2
KNG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 130 100.00 Very High Very High Very High
adenocard 65 100.00 Very High Very High Very High
Pain 28 100.00 Very High Very High Very High
Enkephalin 15 100.00 Very High Very High Very High
ischemia 5 100.00 Very High Very High Very High
qutenza 3 100.00 Very High Very High Very High
Opioid 3 100.00 Very High Very High Very High
substance P 2 100.00 Very High Very High Very High
Serotonin 1 100.00 Very High Very High Very High
metalloproteinase 29 99.34 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 20 100.00 Very High Very High Very High
Cv Unclassified Under Development 16 100.00 Very High Very High Very High
Natriuresis 6 100.00 Very High Very High Very High
Hypersensitivity 6 100.00 Very High Very High Very High
Injury 15 99.88 Very High Very High Very High
Pressure And Volume Under Development 116 99.20 Very High Very High Very High
Fever 3 99.12 Very High Very High Very High
Recurrence 10 99.06 Very High Very High Very High
Myocardial Stunning 3 99.04 Very High Very High Very High
Pressure Volume 2 Under Development 6 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The conversion of plasma prekallikrein to kallikrein by the activated FXII and in response to numerous different stimuli leads to the generation of bradykinin (BK) and activated HK (HKa, an antiangiogenic peptide).
Positive_regulation (activated) of Localization (generation) of bradykinin in plasma associated with bradykinin
1) Confidence 0.30 Published 2009 Journal Cardiovascular & hematological agents in medicinal chemistry Section Abstract Doc Link 19689262 Disease Relevance 0.37 Pain Relevance 0.46
Neutral endopeptidase (NEP) is the major enzyme involved in the metabolic inactivation of a number of bioactive peptides including the enkephalins, substance P, endothelin, bradykinin and atrial natriuretic factor, as well as the incretin hormone glucagon-like peptide 1 (GLP-1), which is a potent stimulator of insulin secretion.
Positive_regulation (inactivation) of Localization (secretion) of bradykinin associated with natriuresis, enkephalin, bradykinin and substance p
2) Confidence 0.27 Published 2007 Journal Acta Crystallogr. D Biol. Crystallogr. Section Abstract Doc Link 17704566 Disease Relevance 0.26 Pain Relevance 0.20
Bradykinin (BK), an important mediator of allergic reactions and pain induction, is released by the activation of the plasma kallikrein-kinin (K-K) cascade.
Positive_regulation (activation) of Localization (released) of Bradykinin in plasma associated with pain, hypersensitivity and bradykinin
3) Confidence 0.26 Published 1992 Journal Biochem. Pharmacol. Section Abstract Doc Link 1562287 Disease Relevance 0.29 Pain Relevance 0.23
Early preconditioning depends on the ischemia-induced release of adenosine and opioids and, to a lesser degree, also bradykinin and prostaglandins.
Positive_regulation (depends) of Localization (release) of bradykinin associated with adenocard, ischemia, bradykinin and opioid
4) Confidence 0.22 Published 2002 Journal Minerva Cardioangiol Section Abstract Doc Link 12473980 Disease Relevance 0.45 Pain Relevance 0.53
Sequence of activation of adenosine and bradykinin receptors and ROS generation
Positive_regulation (activation) of Localization (receptors) of bradykinin associated with adenocard and bradykinin
5) Confidence 0.20 Published 2010 Journal BMC Anesthesiol Section Body Doc Link PMC2919536 Disease Relevance 0 Pain Relevance 0.50
Long-term recovery from an attack presumably requires the stabilization of levels of C1-inhibitor that are sufficiently high to prevent a recurrence of significant contact system activation with resultant bradykinin release.
Positive_regulation (resultant) of Localization (release) of bradykinin associated with bradykinin and recurrence
6) Confidence 0.17 Published 2008 Journal Clin Mol Allergy Section Body Doc Link PMC2374835 Disease Relevance 0.48 Pain Relevance 0.08
This would result in release of bradykinin via contact system activation and would further enhance C1-inhibitor consumption.
Positive_regulation (result) of Localization (release) of bradykinin associated with bradykinin
7) Confidence 0.16 Published 2008 Journal Clin Mol Allergy Section Body Doc Link PMC2374835 Disease Relevance 0.21 Pain Relevance 0.08
After local tissue injury, the release of chemical mediators such as potassium ions, ATP, bradykinin and prostaglandin E2 directly activate nerve endings and indirectly trigger the release of algesic mediators such as histamine, 5-hydroxytryptamine and nerve growth factor from other cells, which, in turn, stimulate proximal afferent nerve endings and silent nociceptors.
Positive_regulation (trigger) of Localization (release) of bradykinin in nerve associated with nerve growth factor, nociceptor, injury and bradykinin
8) Confidence 0.14 Published 1999 Journal Can. J. Gastroenterol. Section Abstract Doc Link 10202208 Disease Relevance 0.72 Pain Relevance 0.87
A role for NK2 receptor stimulation has also been clearly demonstrated in bronchoconstriction induced by various agents known to induce the release of tachykinins (capsaicin, resiniferatoxin, citric acid, sodium metabisulfite diethyl ether, serotonin, and bradykinin), in allergen-induced airway constriction in the guinea pig sensitized to ovalbumin, and in hyperpnea-induced bronchoconstriction.
Positive_regulation (induce) of Localization (release) of bradykinin associated with qutenza, bradykinin and serotonin
9) Confidence 0.12 Published 1995 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 8846425 Disease Relevance 0.23 Pain Relevance 0.50
The released bradykinin moiety potently increases vascular permeability by binding to its cognate receptor (the bradykinin B2 receptor) on vascular endothelial cells.
Positive_regulation (increases) of Localization (released) of bradykinin in endothelial cells associated with b2 receptor and bradykinin
10) Confidence 0.11 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2921104 Disease Relevance 0.96 Pain Relevance 0.31
As a consequence, the proinflammatory pathway is activated through the release of bradykinin, a potent inducer of fever, pain and hypotension.
Positive_regulation (activated) of Localization (release) of bradykinin associated with pain, pressure volume 2 under development, fever and bradykinin
11) Confidence 0.08 Published 1998 Journal Nat. Med. Section Abstract Doc Link 9500602 Disease Relevance 0.84 Pain Relevance 0.15
Acetaldehyde stimulates the release of signaling molecules (epinephrine, norepinephrine, histamine and bradykinin) and leads to the cardiovascular symptoms of the alcohol sensitivity reaction such as vasodilation and facial flushing.
Positive_regulation (stimulates) of Localization (release) of bradykinin associated with increased venous pressure under development, bradykinin and alcohol
12) Confidence 0.07 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872347 Disease Relevance 0.67 Pain Relevance 0.25
Uncontrolled activation of enzymes belonging to various plasma cascades (such as the complement, fibrinolytic, coagulation, and kinin systems) leads to the release of bradykinin, which contributes angioedema formation by enhancing capillary permeability [2].
Positive_regulation (leads) of Localization (release) of bradykinin in capillary associated with pressure and volume under development and bradykinin
13) Confidence 0.01 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2920237 Disease Relevance 0.36 Pain Relevance 0.05
Furthermore, increasing the acetylcholine concentration from 10(-5) to 10(-4) M and using 50 mM K+ increased proportionally the high-molecular-weight peptide secretion.
Positive_regulation (increased) of Localization (secretion) of high-molecular-weight peptide
14) Confidence 0.01 Published 1988 Journal J. Neurochem. Section Abstract Doc Link 3335857 Disease Relevance 0 Pain Relevance 0.90
Venom components implicated in this phenomenon include PLA2, metalloproteinases and serine proteinases that act via the release of endogenous mediators such as arachidonic acid metabolites (leucotrienes and prostaglandins), bradykinin, proinflammatory cytokines and neuronal nitric oxide [23,24,26].
Positive_regulation (via) of Localization (release) of bradykinin in neuronal associated with metalloproteinase, bradykinin and cytokine
15) Confidence 0.01 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3017861 Disease Relevance 0.41 Pain Relevance 0.39

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