INT114808

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Context Info
Confidence 0.50
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.63
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SLC6A3) cell death (SLC6A3) aging (SLC6A3)
plasma membrane (SLC6A3) transmembrane transport (SLC6A3) cytoplasm (SLC6A3)
Anatomy Link Frequency
striatum 2
SLC6A3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 17 100.00 Very High Very High Very High
isoflurane 8 98.72 Very High Very High Very High
imagery 5 97.40 Very High Very High Very High
fluoxetine 1 94.36 High High
dopamine receptor 2 93.28 High High
Serotonin 8 86.72 High High
antagonist 4 77.84 Quite High
antidepressant 3 75.00 Quite High
positron emission tomography 4 71.92 Quite High
Nucleus accumbens 4 49.32 Quite Low
Disease Link Frequency Relevance Heat
Syndrome 78 98.64 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 5 90.08 High High
Tics 62 78.52 Quite High
Congenital Anomalies 6 26.72 Quite Low
Anxiety Disorder 7 5.00 Very Low Very Low Very Low
Obsessive-compulsive Disorder 4 5.00 Very Low Very Low Very Low
Tourette's Syndrome 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BACKGROUND: Isoflurane increases extracellular dopamine concentration and causes trafficking of the dopamine transporter (DAT) in transfected cells.
Positive_regulation (causes) of DAT Binding (trafficking) of associated with dopamine and isoflurane
1) Confidence 0.50 Published 2004 Journal Anesthesiology Section Abstract Doc Link 15505448 Disease Relevance 0 Pain Relevance 0.31
BACKGROUND: Isoflurane increases extracellular dopamine concentration and causes trafficking of the dopamine transporter (DAT) in transfected cells.
Positive_regulation (causes) of dopamine transporter Binding (trafficking) of associated with dopamine and isoflurane
2) Confidence 0.50 Published 2004 Journal Anesthesiology Section Abstract Doc Link 15505448 Disease Relevance 0 Pain Relevance 0.31
Some of these racemic mixtures were resolved to their enantiomers and tested for binding to norepinephrine (NE) transporter (NET), dopamine (DA) transporter (DAT), and alpha(2) receptor.
Positive_regulation (tested) of DAT Binding (binding) of associated with dopamine
3) Confidence 0.49 Published 2003 Journal J. Med. Chem. Section Abstract Doc Link 14640559 Disease Relevance 0 Pain Relevance 0.33
Imaging studies In TS suggest an “overactive DAT [dopamine transporter] system” (Harris et al 2006): for example, SPECT has demonstrated increased dopamine transporter binding in the striatum in patients with TS (Cheon et al 2004; Serra-Mestres et al 2004), suggesting an elevated density of presynaptic dopamine terminals and postsynaptic D2 dopamine receptors, particularly in the ventral striatum (Wong et al 1989; Ernst et al 1999; Wolf et al 1996; Albin et al 2003).
Positive_regulation (increased) of dopamine transporter Binding (binding) of in striatum associated with dopamine, syndrome, dopamine receptor and imagery
4) Confidence 0.01 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646643 Disease Relevance 0.63 Pain Relevance 0.49

General Comments

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