INT114822

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Context Info
Confidence 0.57
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.89
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (PPP2R4) protein folding (PPP2R4) nucleolus (PPP2R4)
ATPase activity (PPP2R4) nucleus (PPP2R4) cytoplasm (PPP2R4)
PPP2R4 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 13 98.22 Very High Very High Very High
Abeta 3 97.48 Very High Very High Very High
Eae 3 91.48 High High
cytokine 1 90.12 High High
Inflammatory response 1 84.80 Quite High
Inflammation 2 82.40 Quite High
cINOD 1 33.60 Quite Low
Disease Link Frequency Relevance Heat
Hypothermia 4 99.96 Very High Very High Very High
Alzheimer's Dementia 4 97.00 Very High Very High Very High
Stress 2 91.44 High High
Disease 7 84.52 Quite High
INFLAMMATION 4 84.44 Quite High
Amyloid Plaque 1 81.72 Quite High
Dementia 1 76.48 Quite High
Cognitive Disorder 2 71.64 Quite High
Delirium 1 64.28 Quite High
Confusion 1 63.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that, regardless of the anesthetic used, anesthesia induced rapid and massive hyperphosphorylation of tau, rapid and prolonged hypothermia, inhibition of Ser/Thr PP2A (protein phosphatase 2A), but no changes in APP metabolism or Abeta (beta-amyloid peptide) accumulation.
Negative_regulation (inhibition) of PP2A associated with hypothermia, anesthesia, alzheimer's dementia and abeta
1) Confidence 0.57 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17376970 Disease Relevance 1.01 Pain Relevance 1.05
Formation of hyperphosphorylated and cross-linked microtubule-associated protein tau aggregates, especially tau dimers as the first step in tangle formation, can be induced in vitro by the combination of okadaic acid, a PP2A phosphatase inhibitor, and methylglyoxal.
Negative_regulation (inhibitor) of PP2A
2) Confidence 0.53 Published 2003 Journal Biochem. Soc. Trans. Section Abstract Doc Link 14641072 Disease Relevance 0.88 Pain Relevance 0.23

General Comments

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