INT114824

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Context Info
Confidence 0.42
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 9.50
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (PTHLH) intracellular (PTHLH) cell-cell signaling (PTHLH)
cytoplasm (PTHLH) extracellular space (PTHLH) extracellular region (PTHLH)
Anatomy Link Frequency
pancreas 4
parathyroid 4
TM3 1
urine 1
PTHLH (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 17 98.48 Very High Very High Very High
Kinase C 2 93.68 High High
Inflammation 27 90.88 High High
abdominal pain 5 88.56 High High
cytokine 10 86.76 High High
Arthritis 13 83.76 Quite High
Calcitonin gene-related peptide 2 79.64 Quite High
antagonist 4 73.68 Quite High
adenocard 10 64.84 Quite High
Osteoarthritis 45 50.00 Quite Low
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 27 100.00 Very High Very High Very High
Hypercalcemia 27 100.00 Very High Very High Very High
Adenosquamous Carcinoma 8 99.66 Very High Very High Very High
Carcinoma 5 99.66 Very High Very High Very High
Rheumatoid Arthritis 17 98.48 Very High Very High Very High
Galactorrhea 74 98.04 Very High Very High Very High
Skin Cancer 6 95.84 Very High Very High Very High
Htlv Types I And Ii 8 94.12 High High
Cancer 13 91.08 High High
INFLAMMATION 26 90.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is a very rare report of adenosquamous cell carcinoma of the pancreas associated with HHM.
HHM Binding (associated) of in pancreas associated with malignant neoplastic disease and carcinoma
1) Confidence 0.42 Published 2008 Journal J Hepatobiliary Pancreat Surg Section Abstract Doc Link 18836809 Disease Relevance 1.57 Pain Relevance 0.07
We report a rare case of adenosquamous carcinoma of the pancreas associated with humoral hypercalcemia of malignancy (HHM) in which parathyroid hormone-related protein (PTH-rP) was identified as the causative factor of hypercalcemia.
PTH-rP Binding (associated) of in pancreas associated with malignant neoplastic disease, adenosquamous carcinoma and hypercalcemia
2) Confidence 0.37 Published 2008 Journal J Hepatobiliary Pancreat Surg Section Abstract Doc Link 18836809 Disease Relevance 1.38 Pain Relevance 0.09
The hypercalcemia was assumed to be due to parathyroid hormone related protein (PHRP), which was demonstrated by immunohistochemistry only in the pleomorphic small cells and not in the squamous cells.
parathyroid hormone related protein Binding (due) of in parathyroid associated with hypercalcemia
3) Confidence 0.37 Published 2003 Journal Dis. Esophagus Section Abstract Doc Link 14641300 Disease Relevance 1.34 Pain Relevance 0.08
However, it is currently recognized that PTHrP is produced by many tissues and is involved in a variety of biological functions by binding to PTH/PTHrP receptor [32].
PTHrP Binding (binding) of
4) Confidence 0.35 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC464878 Disease Relevance 0.61 Pain Relevance 0.26
We report a rare case of adenosquamous carcinoma of the pancreas associated with humoral hypercalcemia of malignancy (HHM) in which parathyroid hormone-related protein (PTH-rP) was identified as the causative factor of hypercalcemia.
HHM Binding (associated) of in pancreas associated with malignant neoplastic disease, adenosquamous carcinoma and hypercalcemia
5) Confidence 0.33 Published 2008 Journal J Hepatobiliary Pancreat Surg Section Abstract Doc Link 18836809 Disease Relevance 1.34 Pain Relevance 0.08
Adenosquamous carcinoma of the pancreas associated with humoral hypercalcemia of malignancy (HHM).
HHM Binding (associated) of in pancreas associated with malignant neoplastic disease, adenosquamous carcinoma and hypercalcemia
6) Confidence 0.33 Published 2008 Journal J Hepatobiliary Pancreat Surg Section Title Doc Link 18836809 Disease Relevance 1.64 Pain Relevance 0.09
At the completion of the urine collection, participants had blood drawn for calcium, phosphorus, parathyroid hormone (PTH), parathyroid related protein (PTH-rP), 1,25-(OH)2 vitamin D, albumin, bone specific alkaline phosphatase, estradiol, luteinizing hormone (LH) and follicle stimulating hormone (FSH).
PTH-rP Binding (drawn) of in urine
7) Confidence 0.31 Published 2007 Journal Int Breastfeed J Section Body Doc Link PMC1950489 Disease Relevance 0.44 Pain Relevance 0
There was also no increase in PTHrP during r-hPRL treatment, an observation that is surprising in light of the association between PTHrP and prolactin in lactating women and women with hyperprolactinemia [20,33,34] and interventional studies in animals [47,48].
PTHrP Binding (association) of associated with galactorrhea
8) Confidence 0.31 Published 2007 Journal Int Breastfeed J Section Body Doc Link PMC1950489 Disease Relevance 0.47 Pain Relevance 0
These five include known inhibitors (quercetin, DBHD, PLP, and PCP), as well as isoprenaline, which binds to SULT1B1 only in the absence of PAP and is a poor substrate for this enzyme (Tables 1 and 2).
PLP Binding (binds) of
9) Confidence 0.20 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1847840 Disease Relevance 0.14 Pain Relevance 0.03
The model of the PTH2R - TIP39 complex was constructed by placing the ECD model in such a manner that TIP39 could reach into the transmembrane region and interact with the top of TM3 and TM7, a region which has been experimentally verified to discriminate binding of PTHrP to PTH2R [37,38].
PTHrP Binding (binding) of in TM3
10) Confidence 0.13 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2991341 Disease Relevance 0 Pain Relevance 0
The parathyroid hormone related protein (PTHrP) binds to and signals only through PTH1R.
PTHrP Binding (binds) of in parathyroid
11) Confidence 0.12 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2991341 Disease Relevance 0 Pain Relevance 0.12
Human orphan receptor, Q8NHB4_Hum, is very closely related to PTRR_Hum receptor binding to parathyroid hormone and parathyroid hormone-related protein (PTHrP).
PTHrP Binding (binding) of in parathyroid
12) Confidence 0.12 Published 2005 Journal BMC Genomics Section Body Doc Link PMC1192796 Disease Relevance 0.29 Pain Relevance 0.04
Human orphan receptor, Q8NHB4_Hum, is very closely related to PTRR_Hum receptor binding to parathyroid hormone and parathyroid hormone-related protein (PTHrP).
parathyroid hormone-related Binding (binding) of in parathyroid
13) Confidence 0.12 Published 2005 Journal BMC Genomics Section Body Doc Link PMC1192796 Disease Relevance 0.29 Pain Relevance 0.04

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