INT114826

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Context Info
Confidence 0.58
First Reported 2003
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 40
Total Number 57
Disease Relevance 22.97
Pain Relevance 3.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (Tymp)
Anatomy Link Frequency
biliary tract 4
bile duct 3
bladder 1
reticulum 1
Tymp (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 38 99.84 Very High Very High Very High
Bile 216 99.20 Very High Very High Very High
interstitial cystitis 9 98.00 Very High Very High Very High
agonist 760 97.74 Very High Very High Very High
palliative 36 94.96 High High
Crohn's disease 1 84.28 Quite High
Inflammation 3 83.04 Quite High
Fibrositis 1 82.48 Quite High
spastic colon 1 81.92 Quite High
Kinase C 38 46.64 Quite Low
Disease Link Frequency Relevance Heat
Cancer 900 99.96 Very High Very High Very High
Aggression 18 99.92 Very High Very High Very High
Gallbladder Neoplasms 108 99.84 Very High Very High Very High
Biliary Cancer 360 99.62 Very High Very High Very High
Klatskin's Tumor 504 99.56 Very High Very High Very High
Recurrence 486 99.52 Very High Very High Very High
Bile Duct Neoplasms 198 99.46 Very High Very High Very High
Interstitial Cystitis 9 98.00 Very High Very High Very High
Hypersensitivity 42 97.20 Very High Very High Very High
Metastasis 108 96.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In comparison, TP expression was significantly higher in GB cancer than in BDC (p = 0.006).
Gene_expression (expression) of TP associated with klatskin's tumor and cancer
1) Confidence 0.58 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 1.04 Pain Relevance 0
Additionally, we examined the expression of TP and ERCC1 associated with the response to 5-FU and cisplatin chemotherapy [15].
Spec (examined) Gene_expression (expression) of TP
2) Confidence 0.58 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 1.29 Pain Relevance 0
However, TP expression was significantly higher in GB cancer than in BDC.
Gene_expression (expression) of TP associated with klatskin's tumor and cancer
3) Confidence 0.58 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 1.20 Pain Relevance 0
Additionally, further studies may be required to evaluate whether TP expression can be used as a predictive marker for the clinical response to capecitabine chemotherapy in GB cancer.


Gene_expression (expression) of TP associated with cancer
4) Confidence 0.50 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 0.82 Pain Relevance 0
Therefore, the sensitivity of tumor cells to capecitabine might be enhanced by increasing TP expression [3,16].
Gene_expression (expression) of TP associated with cancer
5) Confidence 0.50 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 1.05 Pain Relevance 0
This study aims to compare the clinico-pathological characteristics and prognostic factors of GB and bile duct cancers, and also investigate the expression and clinical significance of TP and ERCC1, including several cell-cycle regulatory proteins in biliary tract cancers.


Spec (investigate) Gene_expression (expression) of TP in biliary tract associated with bile and biliary cancer
6) Confidence 0.45 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 0.95 Pain Relevance 0.25
Comparison of thymidine phosphorylase expression and prognostic factors in gallbladder and bile duct cancer

Background

Gene_expression (expression) of thymidine phosphorylase in bile duct associated with bile
7) Confidence 0.45 Published 2010 Journal BMC Cancer Section Title Doc Link PMC2974735 Disease Relevance 0.77 Pain Relevance 0.19
These results are in accordance with previous studies, and the pro-angiogenic activity of TP can explain the more aggressive behavior of TP-expressing tumors [3].


Gene_expression (expressing) of TP associated with cancer and aggression
8) Confidence 0.45 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 1.03 Pain Relevance 0
The immunohistochemical staining patterns of p53, cyclin D1, survivin, thymidine phosphorylase, and ERCC1 showed no prognostic significance in biliary tract cancers.


Gene_expression (patterns) of thymidine phosphorylase in biliary tract associated with biliary cancer
9) Confidence 0.45 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2974735 Disease Relevance 1.24 Pain Relevance 0.26
The goal of this study was to investigate anatomical site-related similarities and differences in biliary tract cancers and to assess the expression and clinical significance of functional proteins such as p53, cyclin D1, survivin, thymidine phosphorylase, and ERCC1.


Gene_expression (expression) of thymidine phosphorylase in biliary tract associated with biliary cancer
10) Confidence 0.45 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2974735 Disease Relevance 0.66 Pain Relevance 0.19
The level of protein expression of p53, cyclin D1, survivin, thymidine phosphorylase, and ERCC1 was assessed by immunohistochemistry.


Gene_expression (expression) of thymidine phosphorylase
11) Confidence 0.45 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2974735 Disease Relevance 0.94 Pain Relevance 0.25
In addition, we hypothesize that high expression of thymidine phosphorylase by gallbladder cancer results in a higher response rate to capecitabine by gallbladder cancer than bile duct cancer.



Gene_expression (expression) of thymidine phosphorylase in bile duct associated with gallbladder neoplasms and bile
12) Confidence 0.45 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2974735 Disease Relevance 1.33 Pain Relevance 0.23
Among the 66 patients who received adjuvant treatment, there was no significant difference in TTR and OS associated with TP and ERCC1 expression (p = 0.212, 0.322 for TP; p = 0.591, 0.794 for ERCC1).


Gene_expression (expression) of TP associated with recurrence
13) Confidence 0.45 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 1.45 Pain Relevance 0
Immunohistochemical analysis revealed that thymidine phosphorylase expression was significantly higher in gallbladder cancer than in bile duct cancer.
Gene_expression (expression) of thymidine phosphorylase in bile duct associated with gallbladder neoplasms and bile
14) Confidence 0.45 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2974735 Disease Relevance 1.35 Pain Relevance 0.28
Among all cases on which interpretation of immunohistochemistry was possible, 72 cases (56.7%) and 35 cases (26.7%) showed positive expression for p53 and cyclin D1, respectively, 54 cases (41.9%) for survivin, and 78 cases (65.0%) for TP.
Gene_expression (expression) of TP
15) Confidence 0.44 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 0.95 Pain Relevance 0
In this study, we cannot access the clinical correlations between TP expression and response to capecitabine and survival, because capecitabine for biliary tract cancers was unavailable in Korea during 1994-2003.
Gene_expression (expression) of TP in biliary tract associated with biliary cancer
16) Confidence 0.39 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 0.99 Pain Relevance 0
The expression of p53, cyclin D1, survivin, TP, and ERCC1 did not independently predict poor outcome in univariate analysis.
Gene_expression (expression) of TP
17) Confidence 0.39 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 1.63 Pain Relevance 0
The expression of TP might be correlated with the efficacy of 5-FU-based chemotherapy [3].
Gene_expression (expression) of TP
18) Confidence 0.39 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 0.79 Pain Relevance 0.15
Determination of the surface expression of TP?
Gene_expression (expression) of TP
19) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0 Pain Relevance 0.04
Secondly, by examining the effects of H2O2 on PC3 cells, which endogenously express a large intracellular pool of both the TP?
Gene_expression (express) of TP
20) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0.08 Pain Relevance 0

General Comments

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