INT114840

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Context Info
Confidence 0.76
First Reported 2003
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 11
Disease Relevance 3.94
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Lgals1) cytoplasm (Lgals1) signal transducer activity (Lgals1)
extracellular space (Lgals1) signal transduction (Lgals1) extracellular region (Lgals1)
Anatomy Link Frequency
PSCs 5
bladder 2
fibroblasts 1
DRG 1
Lgals1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 2 99.68 Very High Very High Very High
Chronic pancreatitis 7 99.24 Very High Very High Very High
dorsal root ganglion 6 99.16 Very High Very High Very High
fibrosis 8 93.92 High High
chemokine 15 91.96 High High
Hippocampus 3 91.60 High High
cytokine 3 87.44 High High
Central nervous system 6 78.24 Quite High
Dorsal horn 3 76.80 Quite High
Neuropathic pain 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Pancreatitis 7 99.24 Very High Very High Very High
Ganglion Cysts 6 99.16 Very High Very High Very High
Primary Sclerosing Cholangitis 8 98.92 Very High Very High Very High
Pancreatic Cancer 7 96.72 Very High Very High Very High
Fibrosis 8 93.92 High High
Overactive Bladder 33 92.72 High High
Apoptosis 7 87.80 High High
Nervous System Injury 8 84.40 Quite High
Neuropathic Pain 2 75.00 Quite High
Lower Urinary Tract Symptoms 18 74.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we show that activation of rat PSCs in vitro is associated with increased expression of galectin-1 (gal-1) and that gal-1 modulates PSC function.
Gene_expression (expression) of galectin-1 in PSCs associated with primary sclerosing cholangitis
1) Confidence 0.76 Published 2005 Journal Cell. Signal. Section Abstract Doc Link 16038798 Disease Relevance 0.39 Pain Relevance 0.14
Here, we show that activation of rat PSCs in vitro is associated with increased expression of galectin-1 (gal-1) and that gal-1 modulates PSC function.
Gene_expression (expression) of gal-1 in PSCs associated with primary sclerosing cholangitis
2) Confidence 0.76 Published 2005 Journal Cell. Signal. Section Abstract Doc Link 16038798 Disease Relevance 0.39 Pain Relevance 0.14
Gal-1-dependent collagen synthesis was blocked by lactose but not by cellobiose, suggesting that gal-1 acts on PSCs through targeting beta-galactoside-containing glycoconjugates.
Gene_expression (synthesis) of Gal-1-dependent in PSCs
3) Confidence 0.76 Published 2005 Journal Cell. Signal. Section Abstract Doc Link 16038798 Disease Relevance 0.42 Pain Relevance 0.16
Galectin-1 was strongly expressed in culture-activated but not freshly isolated PSCs.
Gene_expression (expressed) of Galectin-1 in PSCs
4) Confidence 0.73 Published 2006 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16373424 Disease Relevance 0.15 Pain Relevance 0.24
Previous studies have shown that galectin-1 was expressed in fibroblasts of chronic pancreatitis and of desmoplastic reaction associated with pancreatic cancer.
Gene_expression (expressed) of galectin-1 in fibroblasts associated with pancreatic cancer and chronic pancreatitis
5) Confidence 0.73 Published 2006 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16373424 Disease Relevance 0.20 Pain Relevance 0.17
Expression of galectin-1 was assessed by Western blot analysis, RT-PCR, and immunofluorescent staining.
Gene_expression (Expression) of galectin-1
6) Confidence 0.73 Published 2006 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16373424 Disease Relevance 0.18 Pain Relevance 0.20
PSCs exposed to exogenous gal-1 proliferated at a higher rate and synthesised more collagen than controls.
Gene_expression (synthesised) of gal-1 in PSCs
7) Confidence 0.66 Published 2005 Journal Cell. Signal. Section Abstract Doc Link 16038798 Disease Relevance 0.42 Pain Relevance 0.16
In the present study, we examined whether galectin-1 is colocalized with TrkA or c-Ret mRNA in small DRG neurons and the effect of axotomy on the expression of galectin-1 in the spinal cord.
Gene_expression (expression) of galectin-1 in DRG associated with dorsal root ganglion and spinal cord
8) Confidence 0.60 Published 2003 Journal Brain Res. Section Abstract Doc Link 14642832 Disease Relevance 0.83 Pain Relevance 0.65
In this study, we detected the over-expression of three proteins (OPTN, thioredoxin and preprohaptoglobin), and the under-expression of four proteins (peroxiredoxin 2, transgelin [SM22 alpha], HCNP, and beta-galactoside-binding lectin).
Gene_expression (expression) of beta-galactoside-binding lectin
9) Confidence 0.20 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779299 Disease Relevance 0.31 Pain Relevance 0.08
Four proteins (peroxiredoxin 2, transgelin [SM22 alpha], hippocampal cholinergic neurostimulating peptide [HCNP] and beta-galactoside-binding lectin) were under-expressed in the obstructed bladder.
Gene_expression (expressed) of beta-galactoside-binding lectin in bladder
10) Confidence 0.20 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779299 Disease Relevance 0.34 Pain Relevance 0
In addition, four proteins, such as peroxiredoxin 2, transgelin, hippocampal cholinergic neurostimulating peptide (HCNP) and beta-galactoside-binding lectin, were under-expressed in the bladder of BOO group.
Gene_expression (expressed) of beta-galactoside-binding lectin in bladder
11) Confidence 0.20 Published 2005 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2779299 Disease Relevance 0.33 Pain Relevance 0

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