INT114842

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Context Info
Confidence 0.71
First Reported 2003
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 5.98
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (RET) signal transduction (RET) plasma membrane (RET)
Anatomy Link Frequency
neck 1
plasma 1
head 1
DRG 1
RET (Homo sapiens)
Pain Link Frequency Relevance Heat
dorsal root ganglion 6 99.60 Very High Very High Very High
Spinal cord 2 96.52 Very High Very High Very High
metalloproteinase 53 90.16 High High
Dorsal horn 3 75.00 Quite High
Neuropathic pain 2 75.00 Quite High
intrathecal 1 67.04 Quite High
Catecholamine 60 58.36 Quite High
substance P 1 55.04 Quite High
spinal dorsal horn 1 52.32 Quite High
Peripheral nerve injury 2 46.72 Quite Low
Disease Link Frequency Relevance Heat
Disease 45 100.00 Very High Very High Very High
Thyroid Neoplasm 2 100.00 Very High Very High Very High
Hypercalcemia 2 100.00 Very High Very High Very High
Brain Tumor 2 99.92 Very High Very High Very High
Ganglion Cysts 8 99.60 Very High Very High Very High
Pancreatic Cancer 2 98.84 Very High Very High Very High
Paraganglioma 96 97.48 Very High Very High Very High
Apoptosis 2 91.40 High High
Cancer 142 91.16 High High
Pheochromocytoma 100 89.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Targeted genetic testing should be proposed to patients with phenotypic clues and/or familial history for MEN-2 (medullary thyroid cancer, hyperparathyroidism), VHL disease (hemangioblastoma, renal or pancreatic tumors), or hereditary PGL (head and neck PGL, familial history in the paternal branch).
Localization (disease) of MEN-2 in neck associated with thyroid neoplasm, pancreatic cancer, paraganglioma, hypercalcemia, disease and brain tumor
1) Confidence 0.71 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1702343 Disease Relevance 2.57 Pain Relevance 0.03
RPN 2610, RPN 2617, RPN 2613, RPN 2614, RPN 2611, RPN 2618, RPN 2612) for the determination of MMP1, MMP2, MMP3, MMP9, TIMP1, TIMP2, and MTC1 concentrations in the blood plasma of the patients and the control group.
Localization (concentrations) of MTC1 in plasma
2) Confidence 0.38 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.11 Pain Relevance 0.05
Targeted genetic testing should be proposed to patients with phenotypic clues and/or familial history for MEN-2 (medullary thyroid cancer, hyperparathyroidism), VHL disease (hemangioblastoma, renal or pancreatic tumors), or hereditary PGL (head and neck PGL, familial history in the paternal branch).
Localization (disease) of MEN-2 in head associated with thyroid neoplasm, pancreatic cancer, paraganglioma, hypercalcemia, disease and brain tumor
3) Confidence 0.24 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1702343 Disease Relevance 2.57 Pain Relevance 0.03
In the present study, we examined whether galectin-1 is colocalized with TrkA or c-Ret mRNA in small DRG neurons and the effect of axotomy on the expression of galectin-1 in the spinal cord.
Localization (colocalized) of c-Ret mRNA in DRG associated with dorsal root ganglion and spinal cord
4) Confidence 0.05 Published 2003 Journal Brain Res. Section Abstract Doc Link 14642832 Disease Relevance 0.72 Pain Relevance 0.61

General Comments

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