INT114849

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Context Info
Confidence 0.07
First Reported 2003
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 7.10
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Olr522)
Anatomy Link Frequency
colon 5
Olr522 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 89 100.00 Very High Very High Very High
COX2 2 99.48 Very High Very High Very High
cINOD 23 98.80 Very High Very High Very High
cytokine 5 32.28 Quite Low
aspirin 10 13.72 Low Low
Disease Link Frequency Relevance Heat
Metastasis 250 99.40 Very High Very High Very High
Colon Cancer 163 98.84 Very High Very High Very High
Cancer 105 98.82 Very High Very High Very High
INFLAMMATION 8 98.56 Very High Very High Very High
Aberrant Crypt Foci 13 97.36 Very High Very High Very High
Body Weight 5 84.40 Quite High
Recurrence 10 79.88 Quite High
Polyps 30 75.00 Quite High
Familial Adenomatous Polyposis 10 67.76 Quite High
Targeted Disruption 5 46.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chemopreventive effect of JTE-522, a selective cyclooxygenase-2 inhibitor, on 1, 2-dimethylhydrazine-induced rat colon carcinogenesis.
Negative_regulation (inhibitor) of JTE-522 in colon associated with cox2
1) Confidence 0.07 Published 2003 Journal Cancer Lett. Section Title Doc Link 14643021 Disease Relevance 0.62 Pain Relevance 0.19
The present experiment was designed to assess the potential chemopreventive properties of JTE-522, a new selective cyclooxygenase-2 inhibitor, on the induction of 1,2-dimethylhydrazine (DMH)-induced colonic aberrant crypt foci (ACF), a marker of rat colon carcinogenesis.
Negative_regulation (inhibitor) of JTE-522 in colon associated with aberrant crypt foci
2) Confidence 0.07 Published 2003 Journal Cancer Lett. Section Abstract Doc Link 14643021 Disease Relevance 0.65 Pain Relevance 0.14
Therefore, the influence of JTE-522 (4-(4-cyclohexyl-2-methyloxazol-5-yl)-2-fluorobenzensulfonamide), a selective COX-2 inhibitor, was examined in azoxymethane(AOM)-induced rat colon carcinogenesis.
Negative_regulation (inhibitor) of JTE-522 in colon associated with cox-2 inhibitor
3) Confidence 0.02 Published 2004 Journal Asian Pac. J. Cancer Prev. Section Abstract Doc Link 15373703 Disease Relevance 0.23 Pain Relevance 0.20
JTE-522, a selective COX-2 inhibitor, inhibits growth of pulmonary metastases of colorectal cancer in rats

Background

Negative_regulation (inhibitor) of JTE-522 associated with colon cancer, cox-2 inhibitor and metastasis
4) Confidence 0.01 Published 2005 Journal BMC Cancer Section Title Doc Link PMC555553 Disease Relevance 0.81 Pain Relevance 0.23
In conclusion, JTE-522, a selective COX-2 inhibitor, dose-dependently inhibited the growth of pulmonary metastasis from colorectal cancer in a rat model.
Negative_regulation (inhibitor) of JTE-522 associated with colon cancer, cox-2 inhibitor and metastasis
5) Confidence 0.01 Published 2005 Journal BMC Cancer Section Body Doc Link PMC555553 Disease Relevance 1.48 Pain Relevance 0.21
Because COX-2 inhibitors prevent tumor growth through some mechanisms, we assessed the effect of JTE-522, a selective COX-2 inhibitor, on pulmonary metastases of colon cancer in a rat model.


Negative_regulation (inhibitor) of JTE-522 in colon associated with cancer, colon cancer, cox-2 inhibitor and metastasis
6) Confidence 0.01 Published 2005 Journal BMC Cancer Section Abstract Doc Link PMC555553 Disease Relevance 0.70 Pain Relevance 0.23
The selective COX-2 inhibitor, JTE-522 [15], was suspended in 0.5% carboxymethyl cellulose sodium salt (Wako Life Science Reagents, Osaka, Japan).


Negative_regulation (inhibitor) of JTE-522 associated with cox-2 inhibitor
7) Confidence 0.01 Published 2005 Journal BMC Cancer Section Body Doc Link PMC555553 Disease Relevance 1.28 Pain Relevance 0.12
Thus, we considered that the experimental model of pulmonary metastasis was appropriate for the evaluation of the real effect of JTE-522, a selective COX-2 inhibitor, on hematogenous metastasis of colon cancer in rats.
Negative_regulation (inhibitor) of JTE-522 in colon associated with colon cancer, cox-2 inhibitor and metastasis
8) Confidence 0.01 Published 2005 Journal BMC Cancer Section Body Doc Link PMC555553 Disease Relevance 1.33 Pain Relevance 0.15

General Comments

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