INT11485

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Context Info
Confidence 0.09
First Reported 1992
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 1.81
Pain Relevance 2.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNMA1) transmembrane transport (KCNMA1)
Anatomy Link Frequency
plasma 2
spinal cord 1
epithelial cells 1
KCNMA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 34 100.00 Very High Very High Very High
Pain 11 100.00 Very High Very High Very High
qutenza 4 100.00 Very High Very High Very High
Spinal cord 4 99.68 Very High Very High Very High
Inflammation 11 99.24 Very High Very High Very High
tetrodotoxin 3 95.56 Very High Very High Very High
nociceptor 2 93.92 High High
pain labor 9 84.88 Quite High
antagonist 1 78.32 Quite High
vanilloid receptor subtype 1 1 75.68 Quite High
Disease Link Frequency Relevance Heat
Pain 7 100.00 Very High Very High Very High
Hypersensitivity 2 100.00 Very High Very High Very High
INFLAMMATION 12 99.24 Very High Very High Very High
Reprotox - General 1 3 96.84 Very High Very High Very High
Nociception 10 96.80 Very High Very High Very High
Apoptosis 1 91.88 High High
Pox Virus Infection 1 87.76 High High
Labor Pain 9 84.88 Quite High
Hypertension 1 68.16 Quite High
Endotoxemia 1 67.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The conversion of plasma prekallikrein to kallikrein by the activated FXII and in response to numerous different stimuli leads to the generation of bradykinin (BK) and activated HK (HKa, an antiangiogenic peptide).
Localization (generation) of BK in plasma associated with bradykinin
1) Confidence 0.09 Published 2009 Journal Cardiovascular & hematological agents in medicinal chemistry Section Abstract Doc Link 19689262 Disease Relevance 0.36 Pain Relevance 0.46
Bradykinin (BK), an important mediator of allergic reactions and pain induction, is released by the activation of the plasma kallikrein-kinin (K-K) cascade.
Localization (released) of BK in plasma associated with pain, hypersensitivity and bradykinin
2) Confidence 0.09 Published 1992 Journal Biochem. Pharmacol. Section Abstract Doc Link 1562287 Disease Relevance 0.29 Pain Relevance 0.23
Both contractile and relaxation responses to BK and the release of the prostanoids PGE2, PGI2, and TXA2 by the airway tissues were largely inhibited by indomethacin, whereas TTX had no effect.
Localization (release) of BK associated with tetrodotoxin and bradykinin
3) Confidence 0.07 Published 1994 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 7921430 Disease Relevance 0 Pain Relevance 0.76
Our results suggest that the TRPM8 may be an important new ER Ca(2+) release channel, potentially involved in a number of Ca(2+)- and store-dependent processes in prostate cancer epithelial cells, including those that are important for prostate carcinogenesis, such as proliferation and apoptosis.
Localization (release) of channel in epithelial cells associated with apoptosis and reprotox - general 1
4) Confidence 0.06 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 16174775 Disease Relevance 0.32 Pain Relevance 0.07
TRPV1 is a cation channel activated by capsaicin, heat, various lipids and endogenous hydrogen ions released in tissues during inflammation and is regarded as a key molecule in peripheral nociception [15-17].
Localization (released) of channel associated with nociception, inflammation and qutenza
5) Confidence 0.02 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2254422 Disease Relevance 0.84 Pain Relevance 0.85
A novel two-pore domain K+ channel, TRESK, is localized in the spinal cord.
Localization (localized) of channel in spinal cord associated with spinal cord
6) Confidence 0.02 Published 2003 Journal J. Biol. Chem. Section Title Doc Link 12754259 Disease Relevance 0 Pain Relevance 0.20
We therefore used anti-channel and anti-caveolin antibodies in immunocytochemical analysis to determine whether, in Ltk- cells expressing the WT and mutant channels, the channel proteins and caveolin localize to the same area of the membrane.
Localization (localize) of channel
7) Confidence 0.01 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2785819 Disease Relevance 0 Pain Relevance 0
Channel activity, expression, association, and localization were examined by patch-clamping, Western blot, immunoprecipitation, and immunofluorescence, respectively.


Localization (localization) of Channel
8) Confidence 0.01 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2785819 Disease Relevance 0 Pain Relevance 0.03

General Comments

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