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Context Info
Confidence 0.02
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.71
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp3) peptidase activity (Casp3) mitochondrion (Casp3)
nucleus (Casp3) intracellular (Casp3) kinase activity (Insrr)
Insrr (Mus musculus)
Casp3 (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 9 100.00 Very High Very High Very High
opioid receptor 1 99.00 Very High Very High Very High
antagonist 3 80.28 Quite High
Opioid 2 79.84 Quite High
narcan 1 79.12 Quite High
Glutamate receptor 2 68.08 Quite High
Neuropeptide 1 49.56 Quite Low
Endogenous opioid 1 49.04 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 5 98.28 Very High Very High Very High
Drug Induced Neurotoxicity 2 91.68 High High
Death 2 88.48 High High
Toxicity 2 74.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AMPA/kainate receptor blockade significantly attenuated dynorphin A-induced cytochrome c release and/or caspase-3 activity, while NMDA or opioid receptor blockade typically failed to prevent the apoptotic response.
Negative_regulation (blockade) of receptor Positive_regulation (attenuated) of caspase-3 associated with dynorphin, opioid receptor and apoptosis
1) Confidence 0.02 Published 2003 Journal Neuroscience Section Abstract Doc Link 14643768 Disease Relevance 0.71 Pain Relevance 0.73

General Comments

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