INT114862

Context Info Confidence 0.65 First Reported 2003 Last Reported 2010 Negated 1 Speculated 1 Reported most in Body Documents 16 Total Number 17 Disease Relevance 12.14 Pain Relevance 1.53

cytosol (BEST1) plasma membrane (BEST1)

Anatomy Link Frequency visceral 1 joints 1 coronary artery 1 chest 1 internal 1 BEST1 (Homo sapiens)

Pain Link Frequency Relevance Heat Angina 16 100.00 cva 7 100.00 spastic colon 6 99.48 Pain 14 99.12 rheumatoid arthritis 27 97.82 visual analogue scale 5 90.96 ischemia 38 81.72 Cannabinoid receptor 2 62.56 Enkephalin 2 59.92 Inflammatory marker 4 59.64

Disease Link Frequency Relevance Heat Disease 253 100.00 Coronary Artery Disease 56 100.00 Cv General 3 Under Development 12 100.00 Angina 9 100.00 Pneumonia 1 100.00 Aortic Disease 1 100.00 Targeted Disruption 4 99.88 Functional Bowel Disorder 6 99.48 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super 6 99.46 Anxiety Disorder 2 99.30

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Significant concerns regarding a possible negative impact of ESA therapy on cancer patient outcomes first arose in 2003 with the publication of 2 randomized controlled trials demonstrating increased mortality in patients receiving epoetin beta (ENHANCE)31 or epoetin alfa (BEST),53 respectively.

Gene_expression (receiving) of BEST associated with cancer

1) Confidence 0.65 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697520 Disease Relevance 0.47 Pain Relevance 0.04

Comorbidity information about the concomitance of diabetes mellitus, cardiomyopathy with impaired left ventricular ejection fraction (<50%) and ACE-I or ARB medication were also registered.

Gene_expression (medication) of ARB associated with diabetes mellitus and coronary heart disease

2) Confidence 0.65 Published 2006 Journal BMC Nephrol Section Body Doc Link PMC1578551 Disease Relevance 0.25 Pain Relevance 0

The purpose of this study was to determine the prevalence of low BMD, fractures, and bone pain in all thalassemia syndromes in childhood, adolescence, and adulthood, associations of BMD with fractures and bone pain, and etiology of bone disease in thalassemia.

Spec (determine) Gene_expression (prevalence) of BMD associated with pain, syndrome, thalassemia and bone cancer

3) Confidence 0.41 Published 2009 Journal J. Bone Miner. Res. Section Abstract Doc Link 18505376 Disease Relevance 1.23 Pain Relevance 0.29

The candidate genes Arb, Rpl32, Rpl4, Tbp, Polr2a, Hprt1, Pgk1, Ppia for each species and 18S ribosomal RNA were quantified by RT-qPCR.

Gene_expression (quantified) of Arb

4) Confidence 0.07 Published 2010 Journal BMC Mol Biol Section Body Doc Link PMC2907514 Disease Relevance 0.55 Pain Relevance 0

AIM: To examine the power of correlation between IBS-QOL Questionnare and BEST index in patients with irritable bowel syndrome.

Gene_expression (index) of BEST in bowel associated with spastic colon

5) Confidence 0.04 Published 2008 Journal Eksp Klin Gastroenterol Section Abstract Doc Link 19334419 Disease Relevance 0.17 Pain Relevance 0.17

Statistical analysis to test the correlation between IBS-QOL and BEST index was performed using Spearman's rho coefficient.

Gene_expression (index) of BEST

6) Confidence 0.04 Published 2008 Journal Eksp Klin Gastroenterol Section Body Doc Link 19334419 Disease Relevance 0.09 Pain Relevance 0

There was a striking correlation (r = - 0,8) between BEST and IBS-QOL results.

Gene_expression (results) of BEST

7) Confidence 0.04 Published 2008 Journal Eksp Klin Gastroenterol Section Body Doc Link 19334419 Disease Relevance 0.08 Pain Relevance 0

The analysis of disease activity parameters at inclusion is presented in Table 4 (no statistical difference was found in this analysis).

Neg (no) Gene_expression (presented) of disease associated with disease

8) Confidence 0.03 Published 2009 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2656634 Disease Relevance 0.36 Pain Relevance 0.26

Briefly, these patients had a diagnosis of RA according to the American College of Rheumatology criteria [23], were between 18 and 80 years of age, had a disease duration of less than one year and had active disease defined as a Disease Activity Score of 28 joints (DAS28) of more than 3.0.

Gene_expression (duration) of disease in joints associated with rheumatoid arthritis and disease

9) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656227 Disease Relevance 0.76 Pain Relevance 0.20

A common key question in clinical medicine is whether coronary artery disease (CAD) is present in a patient.

Gene_expression (present) of disease in coronary artery associated with coronary artery disease

10) Confidence 0.02 Published 2005 Journal QJM Section Abstract Doc Link 16087698 Disease Relevance 0.96 Pain Relevance 0.09

Third, other important possible sources of the chest pain, such as pneumonia, pericarditis, and aortic disease, can be seen on the EBCT.

Gene_expression (sources) of disease in chest associated with angina, aortic disease, pneumonia and cva

11) Confidence 0.01 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2628861 Disease Relevance 1.79 Pain Relevance 0.29

Ischaemic heart disease can contribute to erectile dysfunction usually through fear although it can also be the first expression of coronary heart disease.

Gene_expression (expression) of disease in heart associated with reprotox - general 2, coronary artery disease and anxiety disorder

12) Confidence 0.01 Published 2006 Journal Cardiovasc Diabetol Section Body Doc Link PMC1434727 Disease Relevance 1.31 Pain Relevance 0.06

Both visceral and cutaneous forms occur in SSA, with the former producing serious disease associated with high mortality.

Gene_expression (producing) of disease in visceral associated with disease

13) Confidence 0.01 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2727001 Disease Relevance 1.11 Pain Relevance 0

Neglected Tropical Diseases in Sub-Saharan Africa: Review of Their Prevalence, Distribution, and Disease Burden The neglected tropical diseases (NTDs) are the most common conditions affecting the poorest 500 million people living in sub-Saharan Africa (SSA), and together produce a burden of disease that may be equivalent to up to one-half of SSA's malaria disease burden and more than double that caused by tuberculosis.

Gene_expression (produce) of disease associated with mycobacterial infection, malaria and disease

14) Confidence 0.01 Published 2009 Journal PLoS Neglected Tropical Diseases Section Title Doc Link PMC2727001 Disease Relevance 2.15 Pain Relevance 0

So far, only the stereausis model has been demonstrated to produce a CF-dependent best ITD (Joris et al. 2006).

Gene_expression (produce) of best ITD

15) Confidence 0.01 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2576218 Disease Relevance 0 Pain Relevance 0

If internal delays in DNLL reflect those in MSO, our findings set constraints on the candidate mechanisms: a model producing a CF-dependent best ITD should also produce a CF-dependent CD and the correlation between CD and CP that we observe.

Gene_expression (producing) of best ITD in internal

16) Confidence 0.01 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2576218 Disease Relevance 0 Pain Relevance 0

Transgenic mice expressing exon 1 of the human Huntington's disease (HD) gene carrying a 115 CAG repeat (line R6/1) are characterized by a neurologic phenotype involving molecular, behavioral and motor disturbances.

Gene_expression (expressing) of disease associated with targeted disruption and disease

17) Confidence 0.01 Published 2003 Journal Neuroscience Section Abstract Doc Link 14643771 Disease Relevance 0.52 Pain Relevance 0.12

General Comments

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