INT114871

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Context Info
Confidence 0.69
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 12.34
Pain Relevance 4.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Stat3) signal transduction (Stat3) plasma membrane (Stat3)
nucleus (Stat3) DNA binding (Stat3) transcription factor binding (Stat3)
Anatomy Link Frequency
neuronal 2
hepatocyte 2
spinal cord 2
brain 2
nucleus 2
Stat3 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 15 99.98 Very High Very High Very High
Paracetamol 12 99.98 Very High Very High Very High
Inflammation 153 99.76 Very High Very High Very High
IPN 1 99.20 Very High Very High Very High
cytokine 146 99.16 Very High Very High Very High
Spinal cord 3 96.56 Very High Very High Very High
substance P 1 95.76 Very High Very High Very High
Calcitonin gene-related peptide 1 95.12 Very High Very High Very High
Inflammatory response 18 93.28 High High
mu opioid receptor 1 93.28 High High
Disease Link Frequency Relevance Heat
Synovitis 1 99.96 Very High Very High Very High
Obesity 849 99.90 Very High Very High Very High
INFLAMMATION 174 99.76 Very High Very High Very High
Cancer 501 99.72 Very High Very High Very High
Skin Cancer 43 99.22 Very High Very High Very High
Aging 625 99.20 Very High Very High Very High
Inflammatory Pain 1 99.20 Very High Very High Very High
Targeted Disruption 51 98.92 Very High Very High Very High
Neuropathic Pain 1 98.76 Very High Very High Very High
Metastasis 188 93.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MS and KOR agonists induced STAT3 phosphorylation, and STAT3 inhibitor blocked KOR agonist-induced MC proliferation.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of STAT3 associated with agonist
1) Confidence 0.69 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18385270 Disease Relevance 0.44 Pain Relevance 0.68
Moreover, targeting TLR2 in the host or in the melanoma cells markedly inhibited the B16 cell-induced phosphorylation of Stat3 (Fig. 3F).
Positive_regulation (induced) of Phosphorylation (phosphorylation) of Stat3 associated with skin cancer
2) Confidence 0.54 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.58 Pain Relevance 0.04
In contrast, TLR4 KD in B16 cell enhanced the phosphorylation of Stat3 although systemic administration of the anti-TLR4 Ab did not (Fig. 3F).


Positive_regulation (enhanced) of Phosphorylation (phosphorylation) of Stat3
3) Confidence 0.54 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.51 Pain Relevance 0.04
Leptin treatment at 1.0 and 50 nM
                   did not alter the expression of Ob-R and STAT-3 in lean mice although the high
                   but not the low concentration of leptin directly stimulated STAT-3
                   phosphorylation in lean mice.


Neg (not) Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of STAT-3
4) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.96 Pain Relevance 0
Interestingly, short-term leptin supplementation at both 1.0
                   nM and 50 nM significantly upregulated Ob-R expression in young but not aging
                       ob/ob mice and stimulated STAT-3 phosphorylation in both
                   young and aging ob/ob groups. 
Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of STAT-3 associated with aging and obesity
5) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.91 Pain Relevance 0
For instance, epigenetic silencing of the negative regulator SOCS3 occurs in epithelial cancers [47], while other cancers show somatic mutations in Stat3-inactivating phosphatases T and ?
Positive_regulation (mutations) of Phosphorylation (phosphatases) of Stat3-inactivating associated with cancer
6) Confidence 0.49 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.74 Pain Relevance 0.06
The protein levels of p67phox (Fig. 7C and 7D) and phosphorylated STAT3 after LPS (Fig. 7E and 7F) were also higher in the celecoxib-treated mice compared to untreated mice.


Positive_regulation (higher) of Phosphorylation (phosphorylated) of STAT3
7) Confidence 0.45 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.11 Pain Relevance 0.10
Western blotting experiments revealed attenuation of neurofilament hyperphosphorylation, up-regulation of beta-tubulin and actin, and increased phosphorylation of the transcription factor STAT3 in DRG.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of STAT3 in DRG
8) Confidence 0.45 Published 2004 Journal FASEB J. Section Abstract Doc Link 15345684 Disease Relevance 0.57 Pain Relevance 0.29
These results are consensually supported by the studies in which TLR4 activation inhibits phosphorylation and nucleus translocation of Stat3 [21] and activated Stat3 inhibits TLR4 signaling in return via inhibiting transcriptional or translational activity of NF-?
Positive_regulation (activation) of Phosphorylation (phosphorylation) of Stat3 in nucleus
9) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 1.34 Pain Relevance 0.12
production, we evaluated the leptin receptor Ob-R, the post-leptin receptor
                   signaling molecule STAT-3 and STAT-3 phosphorylation. 
Positive_regulation (signaling) of Phosphorylation (phosphorylation) of STAT-3
10) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.94 Pain Relevance 0
production, we evaluated the leptin receptor Ob-R, the post-leptin receptor
                   signaling molecule STAT-3 and STAT-3 phosphorylation. 
Positive_regulation (signaling) of Phosphorylation (phosphorylation) of STAT-3
11) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.94 Pain Relevance 0
Acetaminophen-induced expression of phosphorylated STAT3, a key regulator of cytokine-induced hepatocyte proliferation, was also delayed in TNFR1-/- mice relative to WT.
Positive_regulation (induced) of Phosphorylation (phosphorylated) of STAT3 in hepatocyte associated with paracetamol and cytokine
12) Confidence 0.38 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14644624 Disease Relevance 0.47 Pain Relevance 0.88
Accordingly, mice of both genotypes exhibited a high degree of Stat3 phosphorylation, an important downstream effector of IL6 signaling, which peaked at 4–6 hr after PH (Figure 2B).
Positive_regulation (degree) of Phosphorylation (phosphorylation) of Stat3
13) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0 Pain Relevance 0.05
In contrast, activation of TLR4 inhibited the expression and phosphorylation of Stat3 (Fig. 2A–D).
Positive_regulation (activation) of Phosphorylation (phosphorylation) of Stat3
14) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.25 Pain Relevance 0.21
Activators of neuropathic and inflammatory pain (p38 mitogen-activated protein kinase, STAT3, and mitogen-activated protein kinase/extracellular signal-regulated kinase) showed increased phosphorylation, with accompanying increase in COX-2, interleukin-6, and Toll-like receptor 4 in the spinal cord of hBERK1 compared with HbA-BERK.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of STAT3 in spinal cord associated with ipn, neuropathic pain and spinal cord
15) Confidence 0.36 Published 2010 Journal Blood Section Abstract Doc Link 20304807 Disease Relevance 0.93 Pain Relevance 1.47
The leptin-induced
               STAT-3 phosphorylation was found to be higher along with an upregulated hypothalamic
               expression of the Ob-R at 14 - 18 months of mouse age compared with 2 months of age
                   [41],
               indicating increased leptin sensitivity with aging in the mouse brain. 
Positive_regulation (higher) of Phosphorylation (phosphorylation) of STAT-3 in brain associated with aging
16) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.46 Pain Relevance 0
In murine models of inflammatory synovitis, STAT3 phosphorylation preceded SOCS3 expression, which is consistent with the idea that SOCS3 is part of the STAT3 negative-feedback loop [76].
Positive_regulation (preceded) of Phosphorylation (phosphorylation) of STAT3 associated with inflammation and synovitis
17) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.46 Pain Relevance 0.44
Levels of total and phosphorylated STAT3 were also higher compared with controls, whereas expression and activation of p38 were not affected (Fig. 6 A).
Positive_regulation (higher) of Phosphorylation (phosphorylated) of STAT3
18) Confidence 0.34 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.35 Pain Relevance 0.23
Out of several signaling molecules in the downstream of AT1R, the phosphorylation of ERK, but not Akt or STAT3, was required for synaptophysin degradation (Fig. 5), suggesting that the UPS-dependent synaptophysin degradation is mediated by ERK activation.
Positive_regulation (required) of Phosphorylation (phosphorylation) of STAT3
19) Confidence 0.27 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.11 Pain Relevance 0
In the neuronal cells, angiotensin II treatment also increased the phosphorylated forms of Akt and STAT3 (data not shown).
Positive_regulation (increased) of Phosphorylation (phosphorylated) of STAT3 in neuronal
20) Confidence 0.25 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.27 Pain Relevance 0

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