INT114872

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Context Info
Confidence 0.35
First Reported 2001
Last Reported 2006
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.21
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cdk2) cytoplasm (Cdk2) cytosol (Cdk2)
mitosis (Cdk2) nucleus (Cdk2) cytoskeleton (Cdk2)
Anatomy Link Frequency
hepatocyte 2
BxPC-3 2
Cdk2 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 11 100.00 Very High Very High Very High
Inflammation 3 59.56 Quite High
cytokine 2 37.68 Quite Low
Potency 2 5.84 Low Low
cINOD 4 5.00 Very Low Very Low Very Low
neuralgia 1 5.00 Very Low Very Low Very Low
colic 1 5.00 Very Low Very Low Very Low
Rheumatism 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 3 100.00 Very High Very High Very High
Cancer 32 97.48 Very High Very High Very High
Necrosis 2 90.00 High High
Repression 4 83.36 Quite High
Targeted Disruption 1 80.88 Quite High
Toxicity 1 75.00 Quite High
Apoptosis 38 74.60 Quite High
Death 16 67.76 Quite High
Pancreatic Cancer 15 66.44 Quite High
INFLAMMATION 5 59.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, in TNFR1-/- mice, which exhibit exaggerated acetaminophen hepatotoxicity, hepatocyte proliferation, and expression of cyclin D1 and cyclin A, as well as the cyclin dependent kinases, Cdk4 and Cdk2, were reduced.
Negative_regulation (exhibit) of Gene_expression (expression) of Cdk2 in hepatocyte associated with paracetamol and hepatotoxicity
1) Confidence 0.35 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14644624 Disease Relevance 0.58 Pain Relevance 0.57
Therefore, we examined cyclin D1, E and A cdk2 activities in TM10 and TM2H cell cultures after 24 h treatment with SAHA because they reflect kinase activities before, during and after the G1 ?
Spec (examined) Negative_regulation (examined) of Spec (examined) Gene_expression (activities) of cdk2
2) Confidence 0.18 Published 2001 Journal Breast Cancer Res Section Body Doc Link PMC13923 Disease Relevance 0.08 Pain Relevance 0
Western blot analyses indicated that [6]-gingerol decreased the expression of Cyclin A and Cdks including Cdk2, Cdk4, and Cdk6 in BxPC-3.
Negative_regulation (decreased) of Gene_expression (expression) of Cdk2 in BxPC-3
3) Confidence 0.08 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687755 Disease Relevance 0.54 Pain Relevance 0.03

General Comments

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