INT114873

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Context Info
Confidence 0.82
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 63
Total Number 64
Disease Relevance 30.19
Pain Relevance 8.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Stat3) signal transduction (Stat3) plasma membrane (Stat3)
nucleus (Stat3) DNA binding (Stat3) transcription factor binding (Stat3)
Anatomy Link Frequency
nucleus 6
brain 3
macrophage 1
liver 1
hepatocyte 1
Stat3 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 106 99.82 Very High Very High Very High
Inflammation 681 99.76 Very High Very High Very High
Paracetamol 17 99.54 Very High Very High Very High
IPN 1 99.20 Very High Very High Very High
cytokine 584 99.16 Very High Very High Very High
Spinal cord 13 96.56 Very High Very High Very High
substance P 1 95.76 Very High Very High Very High
Calcitonin gene-related peptide 1 95.12 Very High Very High Very High
narcan 7 94.48 High High
Inflammatory response 126 93.28 High High
Disease Link Frequency Relevance Heat
Synovitis 1 99.96 Very High Very High Very High
Cancer 2436 99.84 Very High Very High Very High
INFLAMMATION 849 99.76 Very High Very High Very High
Obesity 1713 99.68 Very High Very High Very High
Aging 1279 99.24 Very High Very High Very High
Inflammatory Pain 1 99.20 Very High Very High Very High
Skin Cancer 191 99.06 Very High Very High Very High
Metastasis 855 98.80 Very High Very High Very High
Neuropathic Pain 2 98.76 Very High Very High Very High
Targeted Disruption 190 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MS and KOR agonists induced STAT3 phosphorylation, and STAT3 inhibitor blocked KOR agonist-induced MC proliferation.
Phosphorylation (phosphorylation) of STAT3 associated with agonist
1) Confidence 0.82 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18385270 Disease Relevance 0.44 Pain Relevance 0.68
Cell proliferation and STAT3 phosphorylation were analyzed by bromodeoxyuridine (BrdU) ELISA and Western blot, respectively, in MCs in vitro.
Spec (analyzed) Phosphorylation (phosphorylation) of STAT3
2) Confidence 0.82 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18385270 Disease Relevance 0.49 Pain Relevance 0.63
Excessive activation of Stat3 correlates with tumour invasion and metastasis in a variety of cancers [17,18] and high level of tyrosine-phosphorylated STAT3 is a pertinent feature in colon and gastric cancers associated with adverse outcomes [79] (Figure 1).
Phosphorylation (phosphorylated) of STAT3 in colon associated with cancer, stomach cancer and metastasis
3) Confidence 0.81 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.96 Pain Relevance 0.04
level, NADPH oxidase subunit p67phox, and phosphorylated STAT3
Phosphorylation (phosphorylated) of STAT3
4) Confidence 0.80 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.12 Pain Relevance 0.09
Unphosphorylated Stat3 can also cooperate with the NF-?
Phosphorylation (Unphosphorylated) of Stat3
5) Confidence 0.80 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.35 Pain Relevance 0.13
For instance, epigenetic silencing of the negative regulator SOCS3 occurs in epithelial cancers [47], while other cancers show somatic mutations in Stat3-inactivating phosphatases T and ?
Phosphorylation (phosphatases) of Stat3-inactivating associated with cancer
6) Confidence 0.80 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.73 Pain Relevance 0.06
Phosphorylated STAT3 was not detected in the brain nuclear fraction of vehicle-injected mice (Fig. 6D and 6E); however, after LPS, phosphorylated STAT3 protein level increased in both genotypes, but was increased to a greater extent in COX-2-/- mice (Fig. 6D and 6E).


Phosphorylation (Phosphorylated) of STAT3 in brain
7) Confidence 0.79 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.15 Pain Relevance 0.11
Western blotting experiments revealed attenuation of neurofilament hyperphosphorylation, up-regulation of beta-tubulin and actin, and increased phosphorylation of the transcription factor STAT3 in DRG.
Phosphorylation (phosphorylation) of STAT3 in DRG
8) Confidence 0.73 Published 2004 Journal FASEB J. Section Abstract Doc Link 15345684 Disease Relevance 0.56 Pain Relevance 0.29
Acetaminophen-induced expression of phosphorylated STAT3, a key regulator of cytokine-induced hepatocyte proliferation, was also delayed in TNFR1-/- mice relative to WT.
Phosphorylation (phosphorylated) of STAT3 in hepatocyte associated with paracetamol and cytokine
9) Confidence 0.66 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14644624 Disease Relevance 0.42 Pain Relevance 0.88
Also, the TLR2/TLR6 heterodimer is involved in phosphorylation or nuclear translocation of Stat3 induced by macrophage activating lipopeptide-2 or LcrV of Yersinia pestis [28], [29].
Phosphorylation (phosphorylation) of Stat3 in macrophage associated with yersinia infection
10) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.69 Pain Relevance 0.04
These results are consensually supported by the studies in which TLR4 activation inhibits phosphorylation and nucleus translocation of Stat3 [21] and activated Stat3 inhibits TLR4 signaling in return via inhibiting transcriptional or translational activity of NF-?
Phosphorylation (phosphorylation) of Stat3 in nucleus
11) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 1.33 Pain Relevance 0.11
In contrast, TLR4 KD in B16 cell enhanced the phosphorylation of Stat3 although systemic administration of the anti-TLR4 Ab did not (Fig. 3F).


Phosphorylation (phosphorylation) of Stat3
12) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.50 Pain Relevance 0.04
Moreover, targeting TLR2 in the host or in the melanoma cells markedly inhibited the B16 cell-induced phosphorylation of Stat3 (Fig. 3F).
Phosphorylation (phosphorylation) of Stat3 associated with skin cancer
13) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.58 Pain Relevance 0.04
Our results shown in Fig. 6 revealed that obesity,
                   but not aging (12-month), significantly reduced Ob-R protein expression and its
                   post-receptor signaling STAT-3 phosphorylation without affecting the total
                   STAT-3 expression. 
Phosphorylation (phosphorylation) of STAT-3 associated with aging and obesity
14) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.78 Pain Relevance 0
Western blot analysis exhibited reduced
                       Ob-R expression and STAT-3 phosphorylation in both young and aging
                           ob/ob mice, which was restored by leptin. 
Phosphorylation (phosphorylation) of STAT-3 associated with aging and obesity
15) Confidence 0.63 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2852499 Disease Relevance 0.94 Pain Relevance 0
production, we evaluated the leptin receptor Ob-R, the post-leptin receptor
                   signaling molecule STAT-3 and STAT-3 phosphorylation. 
Phosphorylation (phosphorylation) of STAT-3
16) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.94 Pain Relevance 0
production, we evaluated the leptin receptor Ob-R, the post-leptin receptor
                   signaling molecule STAT-3 and STAT-3 phosphorylation. 
Phosphorylation (phosphorylation) of STAT-3
17) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.93 Pain Relevance 0
Interestingly, short-term leptin supplementation at both 1.0
                   nM and 50 nM significantly upregulated Ob-R expression in young but not aging
                       ob/ob mice and stimulated STAT-3 phosphorylation in both
                   young and aging ob/ob groups. 
Phosphorylation (phosphorylation) of STAT-3 associated with aging and obesity
18) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.90 Pain Relevance 0
Leptin treatment at 1.0 and 50 nM
                   did not alter the expression of Ob-R and STAT-3 in lean mice although the high
                   but not the low concentration of leptin directly stimulated STAT-3
                   phosphorylation in lean mice.


Phosphorylation (phosphorylation) of STAT-3
19) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852499 Disease Relevance 0.95 Pain Relevance 0
To measure IL-10 activity, we quantified the phosphorylation balance of the transcription factor STAT-3 by western blot using antibodies against phosphorylated and non-phosphorylated forms of STAT3 (Signalway Antibody Co, USA).
Phosphorylation (phosphorylated) of STAT3
20) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2951918 Disease Relevance 0 Pain Relevance 0

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