INT114874

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Context Info
Confidence 0.76
First Reported 2003
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 78
Total Number 79
Disease Relevance 53.99
Pain Relevance 9.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Stat3) signal transduction (Stat3) plasma membrane (Stat3)
nucleus (Stat3) DNA binding (Stat3) transcription factor binding (Stat3)
Anatomy Link Frequency
nucleus 4
hepatocyte 3
lymphocytes 2
keratinocyte 2
macrophages 1
Stat3 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 142 99.82 Very High Very High Very High
Inflammation 1515 99.44 Very High Very High Very High
cytokine 1023 99.24 Very High Very High Very High
fibrosis 131 99.20 Very High Very High Very High
glial activation 6 99.00 Very High Very High Very High
adenocard 5 98.92 Very High Very High Very High
Central nervous system 174 98.72 Very High Very High Very High
chemokine 194 98.22 Very High Very High Very High
Inflammatory response 224 97.40 Very High Very High Very High
Multiple sclerosis 36 97.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Repression 51 100.00 Very High Very High Very High
Sepsis 25 100.00 Very High Very High Very High
Targeted Disruption 253 99.98 Very High Very High Very High
Cancer 4610 99.84 Very High Very High Very High
Metastasis 739 99.68 Very High Very High Very High
Apoptosis 393 99.68 Very High Very High Very High
Disease 486 99.52 Very High Very High Very High
INFLAMMATION 1761 99.44 Very High Very High Very High
Lymphatic System Cancer 213 99.40 Very High Very High Very High
Wound Healing 113 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the absence of epithelial Stat3 expression, this results in the formation of occasional low-grade intraepithelial neoplastic lesions, while epithelial Stat3 proficiency enables progression of these lesions into advanced tubular tumors [68,84].
Gene_expression (expression) of Stat3 associated with cancer
1) Confidence 0.76 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 1.24 Pain Relevance 0.17
Meanwhile, systemic reduction of Stat3 expression in gp130Y757F;Stat3+/- mice not only prevented gastric tumour formation [31], but also reduced their susceptibility to colonic tumourigenesis in the CAC model [93].
Gene_expression (expression) of Stat3 associated with cancer
2) Confidence 0.76 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.90 Pain Relevance 0.07
Similar findings were obtained in the skin, where keratinocyte-specific Stat3 ablation abrogated skin tumour development [86], while keratinocyte-specific expression of the artificial, transcriptionally constitutive active Stat3C mutant, promoted the formation of squamous cell carcinoma in situ [82].
Gene_expression (expression) of Stat3C in keratinocyte associated with skin cancer
3) Confidence 0.76 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 1.13 Pain Relevance 0.10
Our results suggest that the C57BL/6 background may confer resistance to neurodegeneration by enhancing the expression of survival factors such as acute-phase factor STAT3 and crystallins.
Gene_expression (expression) of STAT3
4) Confidence 0.67 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.99 Pain Relevance 0.16
Meanwhile, systemic reduction of Stat3 expression in gp130Y757F;Stat3+/- mice not only prevented gastric tumour formation [31], but also reduced their susceptibility to colonic tumourigenesis in the CAC model [93].
Gene_expression (/) of Stat3 associated with cancer
5) Confidence 0.66 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.90 Pain Relevance 0.07
In models akin to (onco-)gene amplification, enforced transgenic expression of constitutive active STAT3C confers tumourigenic capacity in a 3T3 xenograph model.
Gene_expression (expression) of STAT3C associated with targeted disruption
6) Confidence 0.66 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 1.22 Pain Relevance 0.14
While epithelial Stat3 activity is dispensable during normal development and tissue homeostasis of the adult intestine, reduction of Stat3 expression, by either ablating il6 [84] or depleting the capacity of gp130 to activate Stat3, increases susceptibility to acute colitis and impairs intestinal wound healing [30].
Gene_expression (expression) of Stat3 in adult intestine associated with colitis and wound healing
7) Confidence 0.66 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 1.15 Pain Relevance 0.07
Accordingly, Stat3 promotes the G1/S phase transition of the cell cycle in gastric, colon and squamous cell carcinoma, as well as in bladder cancer cells [65,68-70].
Gene_expression (promotes) of Stat3 in bladder associated with bladder cancer and skin cancer
8) Confidence 0.66 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 1.10 Pain Relevance 0.04
Cellular outcomes of Stat3 activation
Gene_expression (activation) of Stat3
9) Confidence 0.66 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.81 Pain Relevance 0.03
Like Stat3, canonical activation of NF-?
Gene_expression (canonical) of Stat3
10) Confidence 0.66 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.90 Pain Relevance 0.24
Interestingly, in the context of gp130 mediated Stat activation, Stat1 and Stat3 are capable of regulating each other [32,33].
Gene_expression (capable) of Stat3
11) Confidence 0.66 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.30 Pain Relevance 0.15
In humans STAT3 represents one of the disease loci for Crohn's and inflammatory bowel disease (IBD) [99], and most likely relates to the capacity of Stat3 to promote intestinal barrier function and integrity in response to IL6, IL11 and IL22 exposure.
Gene_expression (represents) of STAT3 in bowel associated with inflammatory bowel disease, inflammation and disease
12) Confidence 0.66 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 1.05 Pain Relevance 0.09
Is excessive Stat3 activation in epithelial cells sufficient to trigger de novo tumour formation?
Gene_expression (activation) of Stat3 in epithelial cells associated with cancer
13) Confidence 0.66 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 1.21 Pain Relevance 0.08
Moreover, the failure to eliminate cyclin D1 in situations of sustained Stat3 activation may not only bypass the DNA replication checkpoint response [153], but also facilitate aberrant chromosome segregation triggered in the absence of functional Apc protein [154].


Gene_expression (activation) of Stat3
14) Confidence 0.66 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.56 Pain Relevance 0
-specific inhibitor reduced Stat3 activation and IL6-target gene expression and ameliorated disease in colitis-prone IL10-deficient mice [117].
Gene_expression (activation) of Stat3 associated with colitis and disease
15) Confidence 0.66 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 1.22 Pain Relevance 0.07
Overexpression of STAT3C in vivo also induced broncho-alveolar adenocarcinomas [94] and the formation of squamous cell carcinoma in situ [82] when expressed in alveolar II epithelial cells or keratinocytes, respectively.
Gene_expression (Overexpression) of STAT3C in keratinocytes associated with bronchiolo-alveolar adenocarcinoma and skin cancer
16) Confidence 0.66 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 1.30 Pain Relevance 0.15
B p65 and STAT3 levels.
Gene_expression (levels) of STAT3
17) Confidence 0.66 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.18 Pain Relevance 0.14
level, NADPH oxidase subunit p67phox, and phosphorylated STAT3
Gene_expression (level) of STAT3
18) Confidence 0.66 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.12 Pain Relevance 0.09
B p65 expression were similar in COX-2+/+ and COX-2-/- mice after LPS, we found that the mRNA expression of STAT3 and the levels of phosphorylated STAT-3 were significantly higher in the COX-2-/- mice compared to wild type mice.
Gene_expression (expression) of STAT3
19) Confidence 0.66 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.57 Pain Relevance 0.36
The expression of STAT3 and SOCS3 mRNA was also significantly increased 24 h after LPS injection in both genotypes compared to the vehicle-injected COX-2+/+ mice (Fig. 6B and 6C), but the increase was significantly higher in COX-2-/- mice than in COX-2+/+ mice.
Gene_expression (expression) of STAT3
20) Confidence 0.66 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.17 Pain Relevance 0.13

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