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Context Info
Confidence 0.35
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.01
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Cdk4) cytosol (Cdk4) signal transduction (Cdk4)
nucleolus (Cdk4) nucleus (Cdk4) cell cycle (Cdk4)
Anatomy Link Frequency
hepatocyte 1
Cdk4 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 11 97.48 Very High Very High Very High
ischemia 2 92.76 High High
cINOD 2 71.36 Quite High
Inflammation 5 70.80 Quite High
Spinal cord 4 51.92 Quite High
imagery 31 39.56 Quite Low
cytokine 2 38.80 Quite Low
fifth nerve 2 32.08 Quite Low
trigeminal ganglion 2 25.76 Quite Low
Eae 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurofibromatosis 2 9 99.56 Very High Very High Very High
Hepatotoxicity 3 97.78 Very High Very High Very High
Cancer 41 94.76 High High
Cv Unclassified Under Development 2 92.76 High High
Brain Injury 2 92.12 High High
Convulsion 2 90.00 High High
Renal Cancer 2 89.28 High High
Meningioma 91 87.04 High High
Disease 120 85.52 High High
Necrosis 2 83.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
decrease in CDK4 kinase activity [74].
Negative_regulation (decrease) of CDK4
1) Confidence 0.35 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559918 Disease Relevance 1.16 Pain Relevance 0.12
In contrast, in TNFR1-/- mice, which exhibit exaggerated acetaminophen hepatotoxicity, hepatocyte proliferation, and expression of cyclin D1 and cyclin A, as well as the cyclin dependent kinases, Cdk4 and Cdk2, were reduced.
Negative_regulation (reduced) of Cdk4 in hepatocyte associated with paracetamol and hepatotoxicity
2) Confidence 0.32 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14644624 Disease Relevance 0.56 Pain Relevance 0.56
found in a plant native to India, Dysoxylum binectariferum, is a potent inhibitor of most CDKs, including CDK1, CDK2, CDK4, and CDK7 [73].
Negative_regulation (inhibitor) of CDK4
3) Confidence 0.26 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559918 Disease Relevance 1.11 Pain Relevance 0.15
It has been shown previously that NF2 expression induces a decrease in cyclin D1 and CDK4 kinase activity, concomitant with dephosphorylation of pRB and reduced DNA synthesis (9, 28).
Negative_regulation (decrease) of CDK4 associated with neurofibromatosis 2
4) Confidence 0.24 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2253711 Disease Relevance 1.18 Pain Relevance 0.03

General Comments

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