INT114876

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Context Info
Confidence 0.38
First Reported 2003
Last Reported 2008
Negated 0
Speculated 2
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.30
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Cdk4) cytosol (Cdk4) signal transduction (Cdk4)
nucleolus (Cdk4) nucleus (Cdk4) cell cycle (Cdk4)
Anatomy Link Frequency
hepatocyte 2
BxPC-3 2
Cdk4 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 11 100.00 Very High Very High Very High
withdrawal 16 95.52 Very High Very High Very High
Inflammation 25 59.56 Quite High
cytokine 2 36.96 Quite Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Intracerebroventricular 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Clonidine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 3 100.00 Very High Very High Very High
Hepatocellular Cancer 44 97.64 Very High Very High Very High
Cancer 37 97.48 Very High Very High Very High
Obesity 29 94.32 High High
Hyperinsulinism 13 91.56 High High
Necrosis 14 90.00 High High
Targeted Disruption 2 80.88 Quite High
Toxicity 1 75.00 Quite High
Apoptosis 64 74.60 Quite High
Death 22 68.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, expression of Cdk4, a gene favoring ?
Negative_regulation (favoring) of Gene_expression (expression) of Cdk4
1) Confidence 0.38 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.69 Pain Relevance 0
In contrast, in TNFR1-/- mice, which exhibit exaggerated acetaminophen hepatotoxicity, hepatocyte proliferation, and expression of cyclin D1 and cyclin A, as well as the cyclin dependent kinases, Cdk4 and Cdk2, were reduced.
Negative_regulation (exhibit) of Gene_expression (expression) of Cdk4 in hepatocyte associated with paracetamol and hepatotoxicity
2) Confidence 0.32 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14644624 Disease Relevance 0.58 Pain Relevance 0.57
Hence, we analyzed the hepatic expression of cyclin E, CDK2, CDK4 and the cell cycle inhibitor p21cip1/waf1 in animals receiving continuous dietary DAB (HC) and in the HR animals.
Spec (analyzed) Negative_regulation (analyzed) of Spec (analyzed) Gene_expression (expression) of CDK4 associated with hepatocellular cancer
3) Confidence 0.11 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1769509 Disease Relevance 0.24 Pain Relevance 0.05
Hence, we analyzed the hepatic expression of cyclin E, CDK2, CDK4 and the cell cycle inhibitor p21cip1/waf1 in animals receiving continuous dietary DAB (HC) and in the HR animals.
Negative_regulation (inhibitor) of Spec (analyzed) Gene_expression (expression) of CDK4 associated with hepatocellular cancer
4) Confidence 0.11 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1769509 Disease Relevance 0.25 Pain Relevance 0.05
Western blot analyses indicated that [6]-gingerol decreased the expression of Cyclin A and Cdks including Cdk2, Cdk4, and Cdk6 in BxPC-3.
Negative_regulation (decreased) of Gene_expression (expression) of Cdk4 in BxPC-3
5) Confidence 0.10 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687755 Disease Relevance 0.54 Pain Relevance 0.03

General Comments

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