INT114877

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Context Info
Confidence 0.69
First Reported 2003
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 5.98
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Cdk4) cytosol (Cdk4) signal transduction (Cdk4)
nucleolus (Cdk4) nucleus (Cdk4) cell cycle (Cdk4)
Anatomy Link Frequency
hepatocyte 1
BxPC-3 1
skin 1
adipocyte 1
Cdk4 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 11 99.06 Very High Very High Very High
agonist 19 94.96 High High
withdrawal 16 94.68 High High
Inflammation 31 59.00 Quite High
cytokine 6 36.96 Quite Low
Eae 3 8.56 Low Low
cINOD 17 5.00 Very Low Very Low Very Low
Intracerebroventricular 8 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
tolerance 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperplasia 18 100.00 Very High Very High Very High
Hepatocellular Cancer 50 99.36 Very High Very High Very High
Hepatotoxicity 3 99.36 Very High Very High Very High
Targeted Disruption 98 99.24 Very High Very High Very High
Hyperinsulinism 26 97.24 Very High Very High Very High
Cancer 193 96.92 Very High Very High Very High
Obesity 68 96.92 Very High Very High Very High
Retinoblastoma 3 96.80 Very High Very High Very High
Congenital Anomalies 11 89.40 High High
Apoptosis 160 86.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, expression of Cdk4, a gene favoring ?
Gene_expression (expression) of Cdk4
1) Confidence 0.69 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.69 Pain Relevance 0
Expression of Insulin, Glucokinase, and Cdk4 was up-regulated to the same extent in islets of adipocyte-deficient and ob/ob mice (Fig. 1 H), and insulin content was significantly increased in islets of adipocyte-deficient mice (Fig.
Gene_expression (Expression) of Cdk4 in adipocyte associated with obesity
2) Confidence 0.69 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.73 Pain Relevance 0
In contrast, in TNFR1-/- mice, which exhibit exaggerated acetaminophen hepatotoxicity, hepatocyte proliferation, and expression of cyclin D1 and cyclin A, as well as the cyclin dependent kinases, Cdk4 and Cdk2, were reduced.
Gene_expression (expression) of Cdk4 in hepatocyte associated with paracetamol and hepatotoxicity
3) Confidence 0.50 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14644624 Disease Relevance 0.57 Pain Relevance 0.57
cyclin D and Cdk4/Cdk6, involved in the G0/G1
Gene_expression (/) of Cdk4
4) Confidence 0.40 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559918 Disease Relevance 0.62 Pain Relevance 0
Expression of Ccne2 (cyclin E) and Cdk4 genes was validated by real time RT-PCR and the results agree with those of microarrays (Figure 5).
Gene_expression (Expression) of Cdk4
5) Confidence 0.39 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2610035 Disease Relevance 0.69 Pain Relevance 0
One of the most affected processes in skin from K14E6 transgenic mice was the cell cycle, which shows overexpression of genes that induced cellular proliferation like cyclins A2, E, D2, B1, B2 and Cdk4 (Figure 4).
Gene_expression (overexpression) of Cdk4 in skin associated with targeted disruption and hyperplasia
6) Confidence 0.30 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2610035 Disease Relevance 0.53 Pain Relevance 0
Notably, forced expression of cyclin D1 along with cdk4 is sufficient to reinitiate cell cycle progression in multiple post-mitotic cell types [47], [48].
Gene_expression (expression) of cdk4
7) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
CDK4, proliferating cell nuclear antigen (PCNA) and cyclin B1, were also found
Gene_expression (found) of CDK4
8) Confidence 0.28 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.60 Pain Relevance 0.11
However, the expressions of various genes involved in cell cycle regulation

(PCNA, c-myc, CDK1, CDK4, and

Gene_expression (expressions) of CDK4
9) Confidence 0.25 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.38 Pain Relevance 0
Hence, we analyzed the hepatic expression of cyclin E, CDK2, CDK4 and the cell cycle inhibitor p21cip1/waf1 in animals receiving continuous dietary DAB (HC) and in the HR animals.
Spec (analyzed) Gene_expression (expression) of CDK4 associated with hepatocellular cancer
10) Confidence 0.19 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1769509 Disease Relevance 0.24 Pain Relevance 0.05
CDK2 expression increased in HR (49%, P < 0.05) respect to control and HC groups, while no variation was detected in CDK4 in any of the tested groups (Fig. 2).
Neg (no) Gene_expression (detected) of CDK4 associated with hepatocellular cancer
11) Confidence 0.17 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1769509 Disease Relevance 0.39 Pain Relevance 0.04
Western blot analyses indicated that [6]-gingerol decreased the expression of Cyclin A and Cdks including Cdk2, Cdk4, and Cdk6 in BxPC-3.
Gene_expression (expression) of Cdk4 in BxPC-3
12) Confidence 0.13 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687755 Disease Relevance 0.54 Pain Relevance 0.03
CUG-BP1 was also phosphorylated at Ser302 by cyclinD3/cdk4 complexes.
Gene_expression (complexes) of cdk4
13) Confidence 0.13 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0 Pain Relevance 0

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