INT114878

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 10.81
Pain Relevance 2.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Stat3) signal transduction (Stat3) plasma membrane (Stat3)
nucleus (Stat3) DNA binding (Stat3) transcription factor binding (Stat3)
Anatomy Link Frequency
hepatocytes 4
nucleus 2
lamina 2
keratinocytes 2
lung 2
Stat3 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 12 99.98 Very High Very High Very High
cytokine 207 99.16 Very High Very High Very High
Inflammation 310 96.88 Very High Very High Very High
Inflammatory response 39 96.52 Very High Very High Very High
Crohn's disease 7 92.08 High High
rheumatoid arthritis 13 89.40 High High
chemokine 34 87.48 High High
tolerance 38 87.44 High High
fibrosis 13 84.20 Quite High
antagonist 8 83.96 Quite High
Disease Link Frequency Relevance Heat
Metastasis 201 99.96 Very High Very High Very High
Lymphatic System Cancer 24 99.92 Very High Very High Very High
Cancer 736 99.84 Very High Very High Very High
Repression 16 99.14 Very High Very High Very High
Skin Cancer 48 98.88 Very High Very High Very High
Bronchiolo-alveolar Adenocarcinoma 2 98.80 Very High Very High Very High
Yersinia Infection 4 98.16 Very High Very High Very High
INFLAMMATION 358 96.88 Very High Very High Very High
Apoptosis 56 96.72 Very High Very High Very High
Inflammatory Bowel Disease 33 96.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of STAT3C in vivo also induced broncho-alveolar adenocarcinomas [94] and the formation of squamous cell carcinoma in situ [82] when expressed in alveolar II epithelial cells or keratinocytes, respectively.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of STAT3C in keratinocytes associated with bronchiolo-alveolar adenocarcinoma and skin cancer
1) Confidence 0.49 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 1.30 Pain Relevance 0.15
Like Stat3, canonical activation of NF-?
Positive_regulation (activation) of Gene_expression (canonical) of Stat3
2) Confidence 0.49 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.90 Pain Relevance 0.24
The expression of STAT3 and SOCS3 mRNA was also significantly increased 24 h after LPS injection in both genotypes compared to the vehicle-injected COX-2+/+ mice (Fig. 6B and 6C), but the increase was significantly higher in COX-2-/- mice than in COX-2+/+ mice.
Positive_regulation (increased) of Gene_expression (expression) of STAT3
3) Confidence 0.49 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.17 Pain Relevance 0.13
on STAT3 repression, an alternative mechanism for PPAR ligand-mediated STAT3 expression, has been suggested, in which the PPAR ligand acts indirectly by stabilizing inflammatory transcription factor suppressor molecules [87].
Positive_regulation (mediated) of Gene_expression (expression) of STAT3 associated with inflammation and repression
4) Confidence 0.45 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.51 Pain Relevance 0.09
Our results suggest that the C57BL/6 background may confer resistance to neurodegeneration by enhancing the expression of survival factors such as acute-phase factor STAT3 and crystallins.
Positive_regulation (enhancing) of Gene_expression (expression) of STAT3
5) Confidence 0.43 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 1.00 Pain Relevance 0.16
Thirdly, TLR2 mediated the HSP60-stimulated the expression of Stat3-controled suppressive factors, such as IL-10, IL-13, TGF-?
Positive_regulation (stimulated) of Gene_expression (expression) of Stat3
6) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.69 Pain Relevance 0.04
Secondly, HSP60 activation of TLR2 mediates the expression and phosphorylation of Stat3 in tumor cells.
Positive_regulation (mediates) of Gene_expression (expression) of Stat3 associated with cancer
7) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.73 Pain Relevance 0.04
Acetaminophen-induced expression of phosphorylated STAT3, a key regulator of cytokine-induced hepatocyte proliferation, was also delayed in TNFR1-/- mice relative to WT.
Positive_regulation (induced) of Gene_expression (expression) of STAT3 in hepatocyte associated with paracetamol and cytokine
8) Confidence 0.38 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14644624 Disease Relevance 0.47 Pain Relevance 0.88
In contrast, activation of TLR4 inhibited the expression and phosphorylation of Stat3 (Fig. 2A–D).
Positive_regulation (activation) of Gene_expression (expression) of Stat3
9) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.25 Pain Relevance 0.21
STAT3 activation and high SOCS3 expression levels have been found in epithelial and lamina propria cells in the colon of IBD (inflammatory bowel disease) model mice, as well as in human ulcerative colitis and patients with Crohn's disease [76], and in synovial fibroblasts of patients with RA [77].
Positive_regulation (high) of Gene_expression (activation) of STAT3 in lamina associated with inflammatory bowel disease, crohn's disease, inflammation, rheumatoid arthritis and disease
10) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.85 Pain Relevance 0.57
Levels of total and phosphorylated STAT3 were also higher compared with controls, whereas expression and activation of p38 were not affected (Fig. 6 A).
Positive_regulation (higher) of Gene_expression (Levels) of STAT3
11) Confidence 0.34 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.35 Pain Relevance 0.23
on STAT3 repression, an alternative mechanism for PPAR ligand-mediated STAT3 expression, has been suggested, in which the PPAR ligand acts indirectly by stabilizing inflammatory transcription factor suppressor molecules [87].
Positive_regulation (mediated) of Gene_expression (expression) of STAT3 associated with inflammation and repression
12) Confidence 0.33 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.51 Pain Relevance 0.09
Blocking Stat3 in highly metastatic melanoma cells suppresses the invasion of the cells and lung metastases; enforcing the expression of cStat3 converts poorly metastatic melanoma cells into highly metastatic cells [7].
Positive_regulation (enforcing) of Gene_expression (expression) of cStat3 in lung associated with skin cancer and metastasis
13) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 1.70 Pain Relevance 0.07
In support of this notion, h-hepatocytes administered with h-GH showed enhanced expression of liver growth-associated h-genes, including IGF-1, STAT-3, Cdc 25A, and cyclinD1, and repopulated the host liver at a rate approximately 6-fold that in the control.
Positive_regulation (enhanced) of Gene_expression (expression) of STAT-3 in hepatocytes
14) Confidence 0.20 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0 Pain Relevance 0
Accumulation of STAT1 in the nucleus and high nuclear levels of phosphorylated STAT3 correlated with a lack in clinical response (Fantin et al. 2008).
Positive_regulation (Accumulation) of Gene_expression (nucleus) of STAT3 in nucleus
15) Confidence 0.14 Published 2010 Journal Clinical Epigenetics Section Body Doc Link PMC3020651 Disease Relevance 0.39 Pain Relevance 0

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